Browsing by Author "Yaşar Şirin, Duygu"
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Are biological agents toxic to human chondrocytes and osteocytes?
İşyar, Mehmet; Bilir, Bülent; Yılmaz, İbrahim; Çakmak, Selami; Yaşar Şirin, Duygu; Yıldırım Güzelant, Aliye; Mahiroğulları, Mahir (BioMed Central, 2015)Purpose: The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Methods: Primary cell cultures obtained from gonarthrosis patients were divided ... -
Are chondrocytes damaged when rheumatologic inflammation is suppressed?
Yıldırım Güzelant, Aliye; İşyar, Mehmet; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Çakmak, Selami; Mahiroğulları, Mahir (Taylor & Francis Inc, 2017)Aim: The use of biological agents (BAs) for treating diseases such as rheumatoid arthritis (RA), spondyloarthropathy, and systemic lupus erythematosus to reduce inflammation has been fruitful. Especially as part of the ... -
Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant?
Kaplan, Necati; Karaaslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akgün, Feride Sinem; Çalışkan, Tezcan; Şimşek, Abdullah Talha; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell cultures were prepared from tissues obtained ... -
Are radio-contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Çalışkan, Tezcan; Özdemir, Çiğdem; Akyuva, Yener; Ateş, Özkan (Wiley, 2019)In the literature, there have been no studies showing clear results on how radio-contrast pharmaceuticals would affect intact disc tissue cells. In this context, it was aimed to evaluate the effects of iopromide and gadoxetic ... -
Are specific gene expressions of extracellular matrix and nucleus pulposus affected by primary cell cultures prepared from intact or degenerative intervertebral disc tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Gönültaş, Aylin; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
Are we economically efficient enough to ıncrease the potential of in vitro proliferation of osteoblasts by means of pharmacochemical agents?
İşyar, Mehmet; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Tosun, Hacı Bayram; Mahiroğulları, Mahir (Bentham Open, 2016)Background: The aim of this study was to test the necessity of using expensive and unaccesible pharmacological-chemical agents in the proliferation of bone tissue cultures and in the induction of mineralized matrix formation ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Chondrocyte proliferation, viability and differentiation is declined following administration of methylphenidate utilized for the treatment of attention-deficit/hyperactivity disorder
Gümüştaş, Funda; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Gümüştaş, Seyit Ali; Batmaz, Ahmet Güray; İşyar, Mehmet; Akkaya, Şeyda; Mahiroğulları, Mahir (Sage Publications Ltd, 2017)Purpose: Methylphenidate (MPH) derivative drugs are used because of psychostimulants effects on attention-deficit hyperactivity disorder in children and adults. As far as we know, toxic or anti-proliferative effects of MPH ... -
Delivering growth factors through a polymeric scaffold to cell cultures containing both nucleus pulposus and annulus fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Karaaslan, Numan; Güler, Olcay; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1) /bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Do we damage nucleus pulposus tissue while treating cerebrovascular ischemic neurological deficits with nimodipine?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Baykız, Derya; Demirkıran, Aykut; Ateş, Özkan (2018)Aim: Nimodipine is used to prevent cerebrovascular-originated ischemic neurological deficits, yet its effects on nucleus pulposus (NP) cells or annulus fibrosus (AF) cells weren’t studied. This study aimed to examine ... -
Does leukocyte-poor or leukocyte-rich platelet-rich plasma applied with biopolymers have superiority to conventional platelet-rich plasma applications on chondrocyte proliferation?
Yaşar Şirin, Duygu; Yılmaz, İbrahim; İşyar, Mehmet; Öznam, Kadir; Mahiroğulları, Mahir (Turkish Joint Diseases Foundation, 2017)Objectives: This study aims to investigate the possible effects of leukocyte concentration in the content of platelet-rich plasma (PRP) and the administration of PRP using a drug delivery system on chondrocyte proliferation ... -
Does oseltamivir protect human chondrocyte and nucleus pulposus cells from degeneration by inhibiting senescence and proinflammation mediated by the NLRP3 inflammasome and NF-kappa B?
Yılmaz, İbrahim; Akalan, Hande; Öznam, Kadir; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Publisher, 2022)OBJECTIVE: Recent drug design studies suggest that inflammation is among the most important factors in the development of both intervertebral disc (IVD) degeneration (IVDD) and osteoarthritis (OA) due to cartilage damage. ... -
Does oseltamivir protect human chondrocyte and nucleus pulposus cells from degeneration by inhibiting senescence and proinflammation mediated by the NLRP3 inflammasome and NF-κB?
Yılmaz, İbrahim; Akalan, Hande; Öznam, Kadir; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Editore s.r.l, 2022)OBJECTIVE: Recent drug design studies suggest that inflammation is among the most important factors in the development of both intervertebral disc (IVD) degeneration (IVDD) and osteoarthritis (OA) due to cartilage damage. ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Kaplan, Necati; Doğan, Mustafa; Gümüştaş, Seyit Ali; Ateş, Özkan; Erdem, İlknur (Inonu University School of Medicine, 2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
Karaarslan, Numan; Batmaz, Ahmet Güray; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Yaşar Şirin, Duygu; Kaplan, Necati; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)Non-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ... -
The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures
Çalışkan, Tezcan; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Termedia Publishing House Ltd, 2022)Introduction: The present study aimed to investigate the potential effects of rivaroxaban, an oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells and the extracellular ... -
Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Kaplan, Necati; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaaslan, Numan; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Bircan, Rıfat; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ... -
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of the nucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahim; Karaarslan, Numan; Bilir, Bülent; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ...
