Browsing by Author "Yılmaz, Bayram"
Now showing items 1-20 of 27
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Adrenergic modulation of melanocortin pathway by hunger signals
Sayar Atasoy, Nilüfer; Laule, Connor; Aklan, İltan; Kim, Hyojin; Yavuz, Yavuz; Ateş, Tayfun; Çoban, İlknur; Köksalar Alkan, Fulya; Rysted, Jacob; Davis, Debbie; Singh, Uday; Alp, Muhammed İkbal; Yılmaz, Bayram; Cui, Huxing; Atasoy, Deniz (Nature Research, 2023)Norepinephrine (NE) is a well-known appetite regulator, and the nor/adrenergic system is targeted by several anti-obesity drugs. To better understand the circuitry underlying adrenergic appetite control, here we investigated ... -
Anticonvulsant activity of resveratrol-loaded liposomes in vivo
Ethemoğlu, Muhsine Sinem; Şeker, Fatma Burcu; Akkaya, Hatice; Kılıç, Ertuğrul; Aslan, İsmail; Erdoğan, Cihan Süleyman; Yılmaz, Bayram (Pergamon-Elsevier Science Ltd, 2017)Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and ... -
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
Effect of c-Abl gene silencing by siRNA on proliferation of mouse granulosa cells
Yaba, Aylin; Agus, Sam; Eyüboğlu, Siğnem; Demir, Necdet; Yılmaz, Bayram (Wiley-Blackwell, 2015)... -
The effect of kisspeptin on spermatogenesis and apoptosis in rats
Aytürk, Nilüfer; Fırat, Tülin; Kükner, Aysel; Özoğul, Candan; Töre, Fatma; Kandıralı, İsmail Engin; Yılmaz, Bayram (TUBITAK Scıentıfıc & Technical Research Council Turkey, 2017)Background/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration ... -
Effects of chronic modulation of kiss1 neurons on catecholamine levels in experimental alzheimer disease's model
Aguş, Sami; Eyüboğlu, Siğnem; Solak, Hatice; Bilgin, Volkan Adem; Yavuz, Yavuz; Akkaya, Hatice; Başer, Özge; Kutlu, Selim; Bingöl, Canan Aykut; Atasoy, Deniz; Yılmaz, Bayram (Wiley, 2018)… -
Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat
Tuğ, Niyazi; Ayvacı Tasan, Habibe; Sargın, Mehmet Akif; Doğan Taymur, Bilge; Ayar, Ahmet; Kılıç, Ertuğrul; Yılmaz, Bayram (Verduci Publisher, 2017)OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It ... -
Effects of memantine and melatonin on signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia in mice
Kılıç, Ülkan; Yılmaz, Bayram; Reiter, Rüssel; Yüksel, Adnan; Kılıç, Ertuğrul (Pergamon-Elsevier Science Ltd, 2013)Because of their favorable action profiles in humans, both memantine and melatonin are particularly interesting candidates as neuroprotectants in acute ischemic stroke. Until now, the signaling mechanisms mediating memantine's ... -
Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation
Kandemir, Başak; Davis, Sabrina; Yiğit, Esra Nur; Öztürk, Gürkan; Yılmaz, Bayram; Laroche, Serge; Aksan Kurnaz, Işıl (Elsevier Ireland Ltd, 2020)Pea3 proteins belong to a subfamily of the E-twentysix (ETS) domain superfamily of transcription factors, which play various roles during development. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are ... -
HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS
Şeker, Fatma Burcu; Kılıç, Ülkan; Çaǧlayan, Berrak; Ethemoğlu, Muhsine Sinem; Çağlayan, Ahmet Burak; Ekimci, Nur; Demirci, Selami; Doǧan, Ayşegül; Öztezcan, Serdar; Şahin, Fikrettin; Yılmaz, Bayram; Kılıç, Ertuğrul (Elsevier, 2015)Apart from its repressing effect on plasma lipid levels, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors exert neuroprotective functions in animal models of neurodegenerative disorders. In view of ... -
Impaired follicular development and ovulation in PCOS mouse model can rescued by rapamycin treatment
Yaba, Aylin; Aydın, Mehmet Şerif; Ağuş, Sami; Günalan, Elif; Yıldırım, Ecem Nur; Yılmaz, Bayram (Oxford University Press, 2018)Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder affecting 5-10% of women in reproductive age that is characterized by hyperandrogenism, oligo- or anovulation and infertility. However the ... -
Inactivation of Magel2 suppresses oxytocin neurons through synaptic excitation-inhibition imbalance
Ateş, Tayfun; Öncül, Merve; Dilsiz, Pelin; Topçu, İskalen Cansu; Cıvaş, Cihan Civan; Alp, Muhammed İkbal; Aklan, İltan; Öz, Edanur Ateş; Yavuz, Yavuz; Yılmaz, Bayram; Atasoy, Nilüfer Sayar; Atasoy, Deniz (Academic Press Inc Elsevier Science, 2019)Prader-Willi and the related Schaaf-Yang Syndromes (PWS/SYS) are rare neurodevelopmental disorders characterized by overlapping phenotypes of high incidence of autism spectrum disorders (ASD) and neonatal feeding difficulties. ... -
Inflammatory cytokines are in action: Brain plasticity and recovery after brain ischemia due to delayed melatonin administration
Kılıç, Ülkan; Elibol, Birsen; Beker, Merve; Altuğ Tasa, Burcugül; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yılmaz, Bayram; Kılıç, Ertuğrul (W.B. Saunders, 2021)Objectives: Post-ischemic inflammation leads to apoptosis as an indirect cause of functional disabilities after the stroke. Melatonin may be a good candidate for the stroke recovery because of its anti-inflammatory effects. ... -
MCH neuron activity ıs sufficient for reward and reinforces feeding
Dilsiz, Pelin; Aklan, İltan; Sayar Atasoy, Nilufer; Yavuz, Yavuz; Filiz, Gizem; Köksalar, Fulya; Ateş, Tayfun; Öncül, Merve; Çoban, İlknur; Ateş Öz, Edanur; Cebecioğlu, Utku; Alp, Muhammed İkbal; Yılmaz, Bayram; Atasoy, Deniz (Karger, 2020)Background: Melanin-concentrating hormone (MCH)-expressing neurons have been implicated in regulation of energy homeostasis and reward, yet the role of their electrical activity in short-term appetite and reward modulation ... -
NTS catecholamine neurons mediate hypoglycemic hunger via medial hypothalamic feeding pathways
Aklan, İltan; Sayar Atasoy, Nilufer; Yavuz, Yavuz; Ateş, Tayfun; Çoban, İlknur; Köksalar, Fulya; Filiz, Gizem; Topçu, İskalen Cansu; Öncül, Merve; Dilsiz, Pelin; Cebecioğlu, Utku; Alp, Muhammed İkbal; Yılmaz, Bayram; Davis, Deborah R.; Hajdukiewicz, Karolina; Saito, Kenji; Konopka, Witold; Cui, Huxing; Atasoy, Deniz (Cell Press, 2020)Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the ...
