Browsing by Author "Vlaisavljevich, Eli"
Now showing items 1-11 of 11
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Bioconjugated beta-cyclodextrin-perfluorohexane nanocone clusters as functional nanoparticles for nanoparticle-mediated histotripsy
Toydemir, Cemran; Hall, Sarah; Demirel, Erhan; Elmacı, Dilşah Nur; Göl, Deniz; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)Nanocone clusters (NCCs) are new-generation agents of nanoparticle-mediated histotripsy (NMH) recently developed to address the limitations of previously designed nanodroplets (NDs). NCCs can be obtained by simply mixing ... -
Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei
Edsall, Connor; Khan, Zerin Mahzabin; Mancia, Lauren; Hall, Sarah; Mustafa, Waleed; Johnsen, Eric; Klibanov, Alexander L.; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (Elsevier Science Inc, 2021)The study described here examined the effects of cavitation nuclei characteristics on histotripsy. Highspeed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from ... -
Development of acoustically active nanocones using the host-guest interaction as a new histotripsy agent
Rehman, Tanzeel Ur; Khirallah, Jennifer; Demirel, Erhan; Howell, Justin; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin (American Chemical Society, 2019)Histotripsy is a noninvasive and nonthermal ultrasound ablation technique, which mechanically ablates the tissues using very short, focused, high-pressured ultrasound pulses to generate dense cavitating bubble cloud. ... -
Effects of droplet composition on nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Durmaz Yüksel, Yasemin; Lin, Kuang-Wei; Fowlkes, Brian; Xu, Zhen; ElSayed, Mohamed E. H. (Elsevier Science Inc, 2016)Nanodroplet-mediated histotripsy (NMH) is a targeted ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells. In two previous studies, polymer-encapsulated perfluoropentane ... -
Effects of ultrasound frequency on nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Yüksel Durmaz, Yasemin; Lin, Kuangwei; Fowlkes, Brian; Elsayed, Mohamed; Xu, Zhen (Elsevier Science, 2015)Nanodroplet-mediated histotripsy (NMH) is a targeted ultrasound ablation technique combining histotripsy with nanodroplets that can be selectively delivered to tumor cells for targeted tumor ablation. In a previous study, ... -
Experimental and computational investigation of clustering behavior of cyclodextrin-perfluorocarbon inclusion complexes as effective histotripsy agents
Kaymaz, Betül; Mustafa, Waleed; Hall, Sarah; Vlaisavljevich, Eli; Şensoy, Özge; Yüksel Durmaz, Yasemin (American Chemical Society, 2022)Recently developed nanocones (NCs), which are inclusion complexes that are made up of cyclodextrins (CDs) and perfluorocarbons (PFCs), have shown promising results in nanoparticle-mediated histotripsy (NMH) applications ... -
Investigation of optimum production conditions and the stability of β-cyclodextrin-perfluorocarbon nanocone clusters for histotripsy applications
Mustafa, Waleed; Hall, Sarah; Huynh, Laura; Mannasse, Rachel; Lüleburgaz, Serter; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin (2024)Nanocone clusters (NCCs) have been developed as clusters with inclusion complexes of FDA-approved β-cyclodextrin (βCD) and perfluorocarbons (PFC) (i.e., perfluoropentane (PFP) and perfluorohexane (PFH)) and have shown ... -
Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'
Khirallah, Jennifer; Schmieley, Rebecca; Demirel, Erhan; Ur Rehman, Tanzeel; Howell, Justin; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (Institute of Physics Publishing, 2019)Nanoparticle-mediated histotripsy (NMH) is an ultrasound treatment strategy that combines acoustically sensitive nanoparticles with histotripsy. Previous NMH studies using perfluorocarbon (PFC) nanodroplets (ND's), ∼200 ... -
Nanoparticle-mediated histotripsy using dual-frequency pulsing methods
Edsall, Connor; Huynh, Laura; Mustafa, Waleed; Hall, Timothy L.; Yüksel Durmaz, Yasemin; Vlaisavljevich, Eli (2024)Objective: Nanoparticle-mediated histotripsy (NMH) is a novel ablation method that combines nanoparticles as artificial cavitation nuclei with focused ultrasound pulsing to achieve targeted, non-invasive, and cell-selective ... -
Noninvasive ablation of prostate cancer spheroids using acoustically-activated nanodroplets
Aydın, Ömer; Vlaisavljevich, Eli; Yüksel Durmaz, Yasemin; Xu, Zhen; ElSayed, Mohamed E. H. (Amer Chemical Soc, 2016)We have developed acoustically activated nanodroplets (NDs) using an amphiphilic triblock copolymer, which self-assembles and encapsulates different perfluorocarbons including perfluoropentane (PFP) and perfluorohexane ... -
The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy
Vlaisavljevich, Eli; Aydın, Ömer; Lin, Kuang-Wei; Durmaz Yüksel, Yasemin; Fowlkes, Brian; ElSayed, Mohamed; Xu, Zhen (Iop Publishing Ltd, 2016)Nanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted ...
