Browsing by Author "Schlechter, Jana"

Now showing items 1-2 of 2

Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition

Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)

Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ...
The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration

Doeppner, Thorsten Roland; Pehlke, Jens; Kaltwasser, Britta; Schlechter, Jana; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Nature Publishing Group, 2015)

Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ...