Browsing by Author "Rabeh, Wael M."

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Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro

Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ...
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target

Ferreira, Juliana C.; Khrbtli, Abdul Rahman; Shetler, Cameron L.; Mansoor, Samman; Ali, Liaqat; Şensoy, Özge; Rabeh, Wael M. (American Society for Biochemistry and Molecular Biology Inc., 2021)

Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ...