Browsing by Author "Pehlke, Jens"

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The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration

Doeppner, Thorsten Roland; Pehlke, Jens; Kaltwasser, Britta; Schlechter, Jana; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Nature Publishing Group, 2015)

Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ...
The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis

Jaeger, Hanna; Pehlke, Jens; Kaltwasser, Britta; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk; Doeppner, Thorsten (Impact Journals, 2015)

N-methyl-D-aspartate receptor (NMDAR) activation induces excitotoxicity, contributing to post-stroke brain injury. Hitherto, NMDAR deactivation failed in clinical trials due to insufficient pre-clinical study designs and ...