Browsing by Author "Okur, Mehmet Evren"
Now showing items 1-20 of 35
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An alternative approach to wound healing field; New composite films from natural polymers for Mupirocin dermal delivery
Okur, Neslihan Üstündağ; Hökenek, Nesrin; Okur, Mehmet Evren; Ayla, Şule; Yoltaş, Ayşegül; Siafaka, Panoraia I.; Cevher, Erdal (Elsevier, 2019)In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release ... -
An alternative approach wound healing field with polypodium vulgare
Batur, Şebnem; Ayla, Şule; Şakul, Ayşe Arzu; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Özdemir, Ekrem Musa; Kepil, Nuray; Günal, Mehmet Yalçın (Logos Medical Publishing, 2020)Objective: In this study, we examined the effects of Polypodium vulgare L. (Polypodiaceae) as a candidate to be used for wound healing scarred area. We investigated the antibacterial, and antioxidant activity of P. Vulgare ... -
Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Kültür, Şükran; Demirci, Betül; Demirci, Fatih (Elsevier Ireland Ltd, 2021)Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air ... -
Antioxidant activity of blackthorn (Prunus spinosa L.) fruit extract and cytotoxic effects on various cancer cell lines
Karakaş, Nihal; Okur, Mehmet Evren; Öztürk, İrem; Ayla, Şule; Karadağ, Ayşe Esra; Polat, Derya Çiçek (Logos Medical Publishing, 2019)Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P. spinosa and its cytotoxic effects ... -
Beta-sitosterol and its antinociceptive mechanism action
Şakul, Ayşe Arzu; Okur, Mehmet Evren (University of Ankara, 2021)Objective: In this study, the possible central antinociceptive activity of beta-sitosterol is investigated along with its association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic receptors to ... -
Beta-sitosterol and its antinociceptive mechanism action
Şakul, Ayşe Arzu; Okur, Mehmet Evren (Ankara University, 2022)Objective: In this study, the possible central antinociceptive activity of beta-sitosterol is investigated along with its association of stimulation of opioidergic, serotonergic, adrenergic, and cholinergic receptors to ... -
Characterization of Opuntia ficus-indica (L.) Mill. fruit volatiles and antibacterial evaluation
Karadağ, Ayşe Esra; Demirci, Betül; Polat, Derya Çiçek; Okur, Mehmet Evren (Badebio Biotechnololgy Ltd, 2018)Opuntia ficus-indica (L.) Mill. fruits known as prickly pear cactus are used in folk medicine as well as food. In the present study it was aimed to extract the volatile constituents of O. ficus-indica fruits by n-hexane. ... -
Deneysel olarak yanık oluşturulmuş sıçanlarda elektromanyetik alan ve piknogenol® uygulamalarının yanık iyileşmesi üzerine etkilerinin değerlendirilmesi
Pertek, Sinem (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Piknogenol, Pinus pinaster bitkisinden elde edilen, içeriğinde flavonoit ve fenolik maddeler bulunan güçlü antioksidan etkiye sahip bir komplekstir. Magnetoterapi (elektromanyetik alan terapisi), manyetik çekim özelliğinden ... -
Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; Physicochemical properties, in vitro release and oral acute toxicity
Siafaka, Panoraia; Okur, Mehmet Evren; Ayla, Şule; Er, Sevda; Çağlar, Emre Şefik; Okur, Neslihan Üstündağ (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)Inorganic and carbon based nanomaterials are widely used against several diseases, such as cancer, autoimmune diseases as well as fungi and bacteria colonization. In this work, Santa Barbara Amorphous mesoporous silica ... -
Detecting and targeting neurodegenerative disorders using electrospun nanofibrous matrices: Current status and applications
Siafaka, Panoraia I.; Özcan Bülbül, Ece; Dilsiz, Pelin; Karantas, Ioannis D.; Okur, Mehmet Evren; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2021)Neurodegeneration is defined as the progressive atrophy and loss of function of neurons; it is present in neurodegenerative disorders such as Multiple Sclerosis, Alzheimer's, Huntington's, and Parkinson's diseases. The ... -
Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats
Okur, Mehmet Evren; Ayla, Şule; Yozgatlı, Vildan; Aksu, Neşe Buket; Yoltaş, Ayşegül; Orak, Duygu; Sipahi, Hande; Üstündaǧ Okur, Neslihan (Elsevier, 2020)The objective of the present research was to examine the possible usage of microemulsion based gel for fusidic acid (FA) dermal application as burn wound treatment. During the preparation of microemulsion, ethyl oleate as ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
Evaluation of in vitro anti-cancer effects of Styphnolobium japonicum root extract in human colon (HT-9), brain (U-87), and prostate (PC-3) cancer cell lines
Okur, Mehmet Evren; Karakaş, Nihal; Karadağ, Ayşe Esra; Öztunç, Nurşah; Tosyalı, İbrahim Serkut; Demirci, Fatih (İstanbul University, 2020)Background and Aims: Styphnolobium japonicum (L.) Schott. (Sophora japonica) is a medicinal plant applied for various diseases, in the traditional medicine field. The evaluation of methanol extract of S. japonicum root ... -
Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
Okur, Mehmet Evren; Çiçek Polat, Derya; Özbek, Hanefi; Yılmaz, Sezen; Yoltaş, Ayşegül; Arslan, Rana (Bentham Science Publ Ltd, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Hemostatic activity of cistus creticus extract in wistar albino rats
Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Okur, Mehmet Evren; Güzelmeriç, Etil; Üstündağ Okur, Neslihan; Tosun, Fatma; Yeşilada, Erdem; Demirci, Fatih (Springer Nature, 2020)Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic ... -
Hypertension in 2017: Update in treatment and pharmaceutical innovations
Okur, Mehmet Evren; Karantas, Ioannis; Okur, Neslihan Üstündağ; Siafaka, Panoraia (Bentham Science Publishers, 2017)Hypertension can be referred to as modern scourge in 2017 and although, it seems that an improvement has been done during the passage of time, the full treatment still remains an unmet achievement for clinicians. Hypertension ... -
Hypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract
Okur, Mehmet Evren; Özbek, Hanefi; Çiçek Polat, Derya; Yılmaz, Sezen; Arslan, Rana (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2018)Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and ... -
Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers
Üstündağ Okur, Neslihan; Yozgatlı, Vildan; Okur, Mehmet Evren; Yoltaş, Ayşegül; Siafaka, Panoraia, I. (Elsevier Science Bv, 2019)The aim of this research was to evaluate the potential use of in situ gel formulations for voriconazole ocular delivery as fungal keratitis treatment. The in situ gelling system was applied to increase residence time and ... -
In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions
Karadağ, Ayşe Esra; Demirci, Betül; Çaşkurlu, Ayşegül; Demirci, Fatih; Okur, Mehmet Evren; Orak, Deborah; Sipahi, Hande; Başer, Kemal Hüznü Can (Elsevier, 2019)Rosmarinus officinalis L. (rosemary) is a common culinary spice and herbal drug, which is used for centuries all over the world. In this present study, apolar to polar fractions of R. officinalis flowers were evaluated for ... -
In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract
Okur, Mehmet Evren; Karakaş, Nihal; Karadağ, Ayşe Esra; Yılmaz, Rabia; Demirci, Fatih (Marmara University, 2019)Marrubium vulgare L. (Lamiaceae) is a herbal drug used for centuries for many diseases. In this present study the plant material was acquired from commercial sources in pharma grade (PhEur 8.0) quality. The methanol extract ...
