Browsing by Author "Labate, Demetrio"
Now showing items 1-5 of 5
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Advances in quantitative analysis of astrocytes using machine learning
Labate, Demetrio; Kayasandık, Cihan Bilge (Wolters Kluwer Medknow Publications, 2023)Astrocytes, a subtype of glial cells, are starshaped cells that are involved in the homeostasis and blood flow control of the central nervous system (CNS). They are known to provide structural and functional support to ... -
Automated detection of GFAP-labeled astrocytes in micrographs using YOLOv5
Huang, Yewen; Kruyer, Anna; Syed, Sarah; Kayasandık, Cihan Bilge; Papadakis, Manos; Labate, Demetrio (Nature Research, 2022)Astrocytes, a subtype of glial cells with a complex morphological structure, are active players in many aspects of the physiology of the central nervous system (CNS). However, due to their highly involved interaction with ... -
Imaging of the axon initial segment
Di Re, Jessica; Kayasandık, Cihan Bilge; Botello-Lins, Gonzalo; Labate, Demetrio; Laezza, Fernanda M. (Blackwell Publishing, Inc., 2019)The axon initial segment (AIS) is the first 20- to 60-μm segment of the axon proximal to the soma of a neuron. This highly specialized subcellular domain is the initiation site of the action potential and contains a high ... -
Inhibition of AKT signaling alters beta IV spectrin distribution at the AIS and increases neuronal excitability
Di Re, Jessica; Hsu, Wei-Chun J.; Kayasandık, Cihan Bilge; Fularczyk, Nickolas; James, Thomas F.; Nenov, Miroslav N.; Negi, Pooran; Marosi, Mate; Scala, Federico; Prasad, Saurabh; Labate, Demetrio; Laezza, Fernanda (Frontiers Media S.A., 2021)The axon initial segment (AIS) is a highly regulated subcellular domain required for neuronal firing. Changes in the AIS protein composition and distribution are a form of structural plasticity, which powerfully regulates ... -
A multistep deep learning framework for the automated detection and segmentation of astrocytes in fuorescent images of brain tissue
Kayasandık, Cihan Bilge; Ru, Wenjuan; Labate, Demetrio (Nature Publishing Group, 2020)While astrocytes have been traditionally described as passive supportive cells, studies during the last decade have shown they are active players in many aspects of CNS physiology and function both in normal and disease ...
