Browsing by Author "Keskin, İlknur"
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Aksolotl rejenerasyonunun farklı evrelerinde miRNA profilinin bulunması ve bulunan miRNA'ların görevlerinin in-siliko analizi
Giriş ve Amaç: Rejenerasyon, fonksiyonel bir kayıp yaşamadan hasarlı dokunun, organın ya da uzvun restore edilmesi işlemidir. Su semenderlerinden olan Aksolotl kendisini öldürmeyecek iç organ, merkezi sinir sistemi ve uzuv ... -
Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells
Bülbül, Muhammet Volkan; Özbek, Hanefi; Bahadır Acıkara, Özlem; Özbilgin, Serkan; Ergene Öz, Burçin; Kurtul, Ekin; Keskin, İlknur (Ondokuz Mayıs University, 2018)In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis ... -
Artificial oocyte activation with calcium ionophore for frozen sperm cycles
Karabulut, Seda; Aksünger, Özlem; Ata, Can; Sağıroğlu, Yusuf; Keskin, İlknur (Taylor and Francis Ltd., 2018)Fertilization problems are the major problems that may be faced in 30-55% of the patients during an intracytoplasmic sperm injection (ICSI) cycle. A successful oocyte activation depends on factors related to both sperm and ... -
The association between the testis microbiota and male infertility
Altun, Ayşe; Bulgurcuoğlu Kuran, Sibel; Keskin, İlknur; Kadıoğlu, Ateş (AVES, 2021)In recent years, substantial findings have been reported about the effects of microbiota on human health. In our study, we aimed to compare the outcomes of microbiota assays of testicular tissue obtained by testicular sperm ... -
Axolotl cells and tissues enhances cutaneous wound healing in mice
Demircan, Turan; Keskin, İlknur; Günal, Yalçın; İlhan, Ayşe Elif; Kolbaşı, Bircan; Öztürk, Gürkan (2016)Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar ... -
Bazı endemik onobrychis türlerinin kolon kanseri hücreleri üzerindeki etkilerinin incelenmesi
Bülbül, Muhammet Volkan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Kanser türlerinin dağılımı ülkelere göre farklılık göstermekle birlikte Kolorektal Kanserler (KRK) gelişmiş ülkelerde en önemli sağlık problemlerinden biri olarak görülmektedirler. Ülkemizde Sağlık Bakanlığı verilerine ... -
Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies
Mermer, Arif; Bülbül, Muhammet Volkan; Kalender, Semiha Mervenur; Keskin, İlknur; Tüzün, Burak; Eyüpoğlu, Ozan Emre (Elsevier B.V., 2022)Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ... -
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice
Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Erdem Altun, Ceren; Çakıcı, Çağrı; Ülfer, Gözde; Müdok, Tangül; Keskin, İlknur (Elsevier Ltd, 2021)Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ... -
Combined therapy with probiotic VSL#3 and Omega-3 fatty acids attenuates colonic injury and inflammation in chronic DNBS-induced colitis in mice
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Devrim Lanpir, Aslı; Ozansoy, Mehmet; Günal, Mehmet Yalçın; Özmen Togay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Kılıç, Ülkan (Polish Academy of Sciences, 2021)Inflammatory bowel disease (IBD) is a progressive chronic inflammatory disease affecting the gastrointestinal tract with a chronic relapsing and remitting disease course. While there are a number of therapeutic strategies ... -
Combined therapy with probiotic VSL#3 and Omega-3 fatty acids attenuates colonic injury and inflammation in chronic DNBS-induced colitis in mice (vol 69, pg 135, 2021)
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Devrim Lanpir, Aslı; Ozansoy, Mehmet; Günal, Mehmet Yalçın; Özmen Toğay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Kılıç, Ülkan (Polish Academy of Sciences, 2022)We published the abovementioned article about probiotic mixture VSL#3 on October 6, 2021. Since the product was named VSL#3 in our purchasing process in early 2016, it is referred to as VSL#3 in our article. In addition, ... -
A comparative study of fixatives for axolotl blastema tissue
Keskin, İlknur; Yıldırım, Berna; Kolbaşı, Bircan; Öztürk, Gürkan; Demircan, Turan (Soc Chilena Anatomia, 2017)Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a ... -
The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats
Soytaş, Mustafa; Gürsoy, Duygu; Boz, Mustafa Yücel; Çakıcı, Çağrı; Keskin, İlknur; Yiğitbaşı, Türkan; Güven, Selçuk; Horuz, Rahim; Albayrak, Selami (Wolters Kluwer Medknow Publications, 2021)Background and Aim: This study aims to establish unilateral intermittent and unintermittent partial nephrectomy-like renal ischemia-reperfusion (I-R) model in rats and to compare the results with biochemical findings. ... -
Detailed morphological analysis of axolotl sperm
Keskin, İlknur; Gürsoy Gürgen, Duygu; Avinca, Didem; Özdemir, Ekrem Musa; Keskin, Suat Utku; Karabulut, Seda (Korean Society of Veterinary Science, 2021)The axolotl has extraordinary regeneration capacity compared to other vertebrates. This remarkable potential has been attributed to its life-long neoteny, characterized by the exhibition of embryonic characteristics at the ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
Demircan, Turan; Keskin, İlknur; Dumlu, Seda Nilgün; Aytürk, Nilüfer; Avşaroğlu, Mahmut Erhan; Akgün, Emel; Öztürk, Gürkan; Baykal, Ahmet Tarık (Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
Dondurulmuş ejekülat ve dondurulmuş testiküler spermin sonuçlarının intrasitoplazmik sperm enjeksiyonu (ICSI) parametrelerine etkisinin değerlendirilmesi
Karabulut, Seda; Korkmaz, Oya; Sağıroğlu, Yusuf; Keskin, İlknur (Avrasya Üroonkoloji Derneği, 2019)Amaç: Çalışmamızda, dondurulmuş ejekülat ve dondurulmuş testiküler spermin İntrasitoplaz - mik Sperm Enjeksiyonu (ICSI) sonuçları üzerine etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmamızda 11.10.2016- ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
Keskin, İlknur; Günal, Mehmet Yalçın; Aytürk, Nilüfer; Kılıç, Ülkan; Ozansoy, Mehmet; Kılıç, Ertuğrul (Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
Effect of oral use of various edible oils on wound healing in rats: Randomized controlled experimental study
Çakmak Kafadar, Gökçe; Büyükuslu, Nihal; Kolbaşı, Bircan; Keskin, İlknur; Mercan, Yeliz (Istanbul Medipol University, 2022)There are various studies showing that oral supplements are shortening or facilitat-ing effects on this process. Therefore, this study investigates the use of edible oils as supplements in the wound healing process. Of the ... -
The effect of probiotic and omega-3 supplements on total oxidant and total antioxidant levels in experimental colitis
Yoldaş İlktaç, Havvanur; Kızıltan, Gül; Ozansoy, Mehmet; Kılıç, Ülkan; Özmen Toğay, Sine; Keskin, İlknur; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2021)Objective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to ...
