Browsing by Author "Kaya, Yasin Emre"
Now showing items 1-14 of 14
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Are we using slow-acting symptomatic chondroprotective drugs conscious enough?
Gümüştaş, Seyit Ali; Öznam, Kadir; Mutlu, Çağrı Ata; Kaya, Yasin Emre; Yılmaz, İbrahim; İşyar, Mehmet; Yıldırım Güzelant, Aliye; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Bentham Open, 2017)Background: Osteochondral injuries constitute an entity that is widespread and can be seen in patients of all ages. Actual treatment modalities aim to relieve pain, obtain full range of movement of the joint, and improve ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular matrix structures?
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Kaya, Yasin Emre; Yaşar, Şirin, Duygu; Özbek, Hanefi (Bentham Science Publishers, 2019)Background: The study aimed to investigate the effects of the active ingredient, nimodipine, on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells. Methods: Chondrocyte cultures ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Kaplan, Necati; Doğan, Mustafa; Gümüştaş, Seyit Ali; Ateş, Özkan; Erdem, İlknur (Inonu University School of Medicine, 2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
Çalışkan, Tezcan; Şirin, Duygu Yaşar; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Akyuva, Yener; Kaplan, Necati; Kaya, Yasin Emre; Şimşek, Abdullah Talha; Güzelant, Aliye Yıldırım; Ateş, Özkan (Spandidos Publications, 2019)The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ... -
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of the nucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahim; Karaarslan, Numan; Bilir, Bülent; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ... -
Investigation of the effect of dipyrone on cells isolated from intervertebral disc tissue
Akgün, Feride Sinem; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Şimşek, Abdullah Talha; Kaya, Yasin Emre; Kaplan, Necati; Akyuva, Yener; Çalışkan, Tezcan; Ateş, Özkan (Spandidos Publications, 2019)The present study aimed to evaluate the effects of dipyrone, an indispensable analgesic, anti-pyretic and anti-spasmodic used in emergency departments, on nucleus pulposus and annulus fibrosus cells in vitro. After surgical ... -
Investigation of the effects of methylphenidate, an amphetamine derivative, on intervertebral disc tissue cell cultures and matrix structures
Kaya, Yasin Emre; Karaarslan, Numan; Şirin, Duygu Yaşar; Özbek, Hanefi; Kaplan, Necati; Yılmaz, İbrahim (Turkish Neurosurgical Society, 2019)AIM: To investigate the effects of methylphenidate (MPH), on intervertebral disc tissue (IVD) cell cultures and extracellular matrix structures. Changes in the expression of some important marker genes involved in anabolic ... -
Investigation of the effects of tigecycline, a semi-synthetic derivative of minocycline, on chondrocyte cultures
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Yaman, Onur; Özbek, Hanefi; Ateş, Özkan (Annals of Medical Research Publishing Inc, 2020)Abstract Aim: Although antibiotics are generally well-tolerated, they may have cytotoxic effects. The present randomized, double-blind, in vitro study aimed to investigate the effects of tigecycline on cartilage tissue ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
A study of the effects of metformin, a biguanide derivative, on annulus fibrosus and nucleus pulposus cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Society, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues.MATERIAL ... -
A study on the effects of direct factor Xa inhibitors and direct thrombin inhibitors on human primary chondrocyte cultures
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi; Ateş, Özkan (Namık Kemal University, 2019)Aim:This study investigates the effects of two direct factor Xa inhibitors, apixaban and rivaroxaban, and a direct thrombin inhibitor, dabigatran, on human primary chondrocytecultures. Materials and Methods:Monolayer ...
