Browsing by Author "Karakaş, Nihal"
Now showing items 1-20 of 21
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Antioxidant activity and anti-cancer effects of bilberry (vaccinium myrtillus l.) fruit extract on gastric cancer, ags cell line
Karakaş, Nihal; Okur, Mehmet Evren; Sağır, Tuğba; Uludağ, Damla; Polat, Derya Çiçek; Karadağ, Ayşe Esra (Ankara University, 2022)Objective: Vaccinium myrtillus L. fruits are consumed as food. This research was aimed to evaluate V. myrtillus methanol extract antioxidant and cytotoxic activities and determine its anti-cancer potential to further study ... -
Antioxidant activity of blackthorn (Prunus spinosa L.) fruit extract and cytotoxic effects on various cancer cell lines
Karakaş, Nihal; Okur, Mehmet Evren; Öztürk, İrem; Ayla, Şule; Karadağ, Ayşe Esra; Polat, Derya Çiçek (Logos Medical Publishing, 2019)Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P. spinosa and its cytotoxic effects ... -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
DU 145 insan prostat kanseri hücrelerinde Hsa-Mir-8072’nin potansiyel rolü
Ayla, Şule; Parlayan, Cüneyd; Karakaş, Nihal; Açıkgöz, Eda; Öktem, Gülperi (Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2019)Amaç: Çalışmamızda, insan prostat kanser hücre hattı (DU145) ve prostat normal epitel hücre hatları (RWPE) arasında miRNA ifadesinin analizini yapmak ve kanser gelişiminde olası rolünü incelemeği amaçladık. Gereçler ve ... -
Evaluation of in vitro anti-cancer effects of Styphnolobium japonicum root extract in human colon (HT-9), brain (U-87), and prostate (PC-3) cancer cell lines
Okur, Mehmet Evren; Karakaş, Nihal; Karadağ, Ayşe Esra; Öztunç, Nurşah; Tosyalı, İbrahim Serkut; Demirci, Fatih (İstanbul University, 2020)Background and Aims: Styphnolobium japonicum (L.) Schott. (Sophora japonica) is a medicinal plant applied for various diseases, in the traditional medicine field. The evaluation of methanol extract of S. japonicum root ... -
Glioblastoma multiforme beyin tümörünün erken tanı ve tedavisine imkan sağlayabilecek anti-GBM otoantikorların araştırılması
Topçu, Ozan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Glioblastom (GB) son derece invazif karaktere sahip malign bir beyin tümörüdür. Glioblastom hastaları ortalama 12-15 ay arası yaşamlarını sürdürebilmektedir. Dolayısıyla hastalığa erken tanı konulabilmesi büyük önem arz ... -
Hedefe yönelik olarak geliştirilen toksin füzyonunun çeşitli kanser hücrelerinde in vitro tedavi edici etkisinin incelenmesi
Uludağ, Damla (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Kanser hastalığı, tüm toplumlarda yaygın olarak görülmesine rağmen; genomik değişkenlik, tümörün nüks etmesi, kanser hücrelerinin heterojenitesi, sistemik toksisite gibi nedenlerden ötürü uygulanan tedavi yöntemleri yetersiz ... -
IL13 fused pseudomonas exotoxin targets various cancers in vitro
Uludağ, Damla; Karakaş, Nihal (International Institute of Anticancer Research, 2021)Background/Aim: Pseudomonas exotoxin (PE) is one of the most widely used toxins in the construction of therapeutic fusion proteins in pre-clinical studies followed by phase trials. In principle, PE acts by blocking protein ... -
IL13R alpha 2-and EGFR-targeted pseudomonas exotoxin potentiates the TRAIL-mediated death of GBM cells
Karakaş, Nihal; Stuckey, Daniel; Revai-Lechtich, Esther; Shah, Khalid (Spandidos Publications Ltd, 2021)Glioblastomas (GBMs) are refractory to current treatments and novel therapeutic approaches need to be explored. Pro-apoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is tumor-specific and has been ... -
In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract
Okur, Mehmet Evren; Karakaş, Nihal; Karadağ, Ayşe Esra; Yılmaz, Rabia; Demirci, Fatih (Marmara University, 2019)Marrubium vulgare L. (Lamiaceae) is a herbal drug used for centuries for many diseases. In this present study the plant material was acquired from commercial sources in pharma grade (PhEur 8.0) quality. The methanol extract ... -
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
İlter, Metehan; Kaşmer, Ramazan; Jalalypour, Farzaneh; Atılgan, Canan; Topçu, Ozan; Karakaş, Nihal; Şensoy, Özge (NLM (Medline), 2022)Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ... -
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
Karakaş, Nihal; Kılıç, Ülkan (International Institute of Anticancer Research, 2021)Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ... -
Investigation of antioxidant and cytotoxic activities of Opuntia ficus-indica (L.) Mill. fruit extract
Okur, Mehmet Evren; Karakaş, Nihal; Karadağ, Ayşe Esra; Uludağ, Damla; Çiçek Polat, Derya (Istanbul University, 2019)Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the ... -
İnsan mezenkimal kök hücrelerinin fonksiyonel nöronlara farklılaştırılması
Öztunç, Nurşah (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Nöronlara farklılaşma kapasitesi ve klinik uygulanabilirliği ile mezenkimal kök hücreler, doku rejenerasyonu ve nörogelişimsel süreçleri anlamak için yürütülen çalışmalarda en önemli yetişkin kök hücre kaynağını oluşturmaktadır. ... -
Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines
Karakaş, Nihal; Okur, Mehmet Evren; Öztunç, Nurşah; Polat, Derya Çiçek; Karadağ, Ayşe Esra (Walter de Gruyter GmbH, 2021)Objectives: Laurocerasus officinalis Roem. fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported ... -
Mesenchymal stem cell-based COVID-19 therapy: Bioengineering perspectives
Karakaş, Nihal; Üçüncüoğlu, Süleyman; Uludağ, Damla; Karaoğlan, Birnur Sinem; Shah, Khalid; Öztürk, Gürkan (MDPI, 2022)The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) are currently utilized in clinics for pulmonary inflammatory ... -
Nanokorlar: Tanı ve tedaviye yönelik antikor fragmanları
Karakaş, Nihal; Öztürk, İrem; Tosyalı, Serkut; Bay, Sadık (2018)Nanokorlar, bilinen en küçük ve fonksiyonel antikor fragmanlarıdır. Yapısında sadece iki ağır zincir bulunduran antikorların (heavy chain only antibodies; HcAb) antijen bağlama bölgesi, “nanokor” (nanobody) olarak ... -
Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
Karakaş, Nihal; Bay, Sadık; Türkel, Nezaket; Öztunç, Nurşah; Öncül, Merve; Bilgen, Hülya; Shah, Khalid; Şahin, Fikrettin; Öztürk, Gürkan (Public Library of Science, 2020)Mesenchymal stem cells have the ability to transdifferentiate into neurons and therefore one of the potential adult stem cell source for neuronal tissue regeneration applications and understanding neurodevelopmental ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
Onur Sucu, Bilgesu; Savluğ İpek, Özgecan; Özdatlı Kurtuluş, Şükran; Yazıcı, Büşra Emine; Karakaş, Nihal; Güzel, Mustafa (Academic Press Inc Elsevier Science, 2019)Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in ...
