Browsing by Author "Kılıç, Ertuğrul"
Now showing items 1-20 of 150
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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; Eysmondt, Hendrik von; Dandekar, Thomas; Heinzmann, David; Günter, Manina; Ungern-Sternberg, Saskia von; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Çağlar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kılıç, Ertuğrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad (Nature Research, 2022)Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25
Kuang, Yaoyun; Zheng, Xuan; Zhang, Lin; Ai, Xiaoyu; Venkataramani, Vivek; Kılıç, Ertuğrul; Hermann, Dirk M.; Majid, Arshad; Baehr, Mathias; Doeppner, Thorsten R. (Taylor & Francis Ltd, 2020)Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has not yet been identified. To investigate ... -
Akım sitometri tekniği ile yeni doğan fare beyninden bölgesel olarak izole edilmiş spesifik hücrelerin protein profillerinin incelenmesi
Vatandaşlar, Emre (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Memeli santral sinir sistemi (SSS) yapısal ve işlevsel organizasyonu ile yaşayan organizmalar arasında en karmaşık yapıya sahip olan sistemdir. Bu kompleks sistemin işleyiş mekanizması ise ancak beyni oluşturan hücrelerin, ... -
Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
Allyl isothiocyanate enhances brain neuronal plasticity proteins via inhibition of inflammation proteins
Juturu, Vijaya; Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Tuzcu, Mehmet; Erten, Füsun; Günal, Mehmet Yalçın; Altunay, Serdar; Orhan, Cemal; Şahin, Kazım (Lippincott Williams & Wilkins, 2018)… -
Anticonvulsant activity of resveratrol-loaded liposomes in vivo
Ethemoğlu, Muhsine Sinem; Şeker, Fatma Burcu; Akkaya, Hatice; Kılıç, Ertuğrul; Aslan, İsmail; Erdoğan, Cihan Süleyman; Yılmaz, Bayram (Pergamon-Elsevier Science Ltd, 2017)Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Beyin felci sonrası melatonin ve BMAL 1 proteinin ilişkisinin araştırılması
Sertel, Elif (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Canlılar çevrelerinde meydan gelen değişikliklere adapte olabilmek için davranışsal ve fizyolojik süreçlerini düzenlerler. Canlılardaki bu süreçler sirkadyen ritimle düzenlenmekte ve çevresel değişikliklere senkronize ... -
Beyin felci sonrası meydana gelen plastisite ile ilgili patofizyolojik süreçlerin ileri mikroskopi teknikleriyle incelenmesi
Keleştemur, Taha (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Beyin felci insanlarda en fazla motor fonksiyon bozukluklarına neden olan hastalıktır. Beyin felci sonrası post-iskemik fazda beynin endojen onarım mekanizmalarının etkinleştirilerek fonksiyonel olarak iyileşmesi, ... -
Beyond the therapeutic effect of RTMS in Alzheimer’s disease: A possible neuroprotective role of hippocampal BDNF?: A minireview
Yuluğ, Burak; Hanoğlu, Lütfü; Khanmammadov, Elmir; Arıcı Düz, Özge; Polat, Burcu; Hanoğlu, Taha; Günal, Mehmet Yalçın; Kılıç, Ertuğrul (Bentham Science Publishers B.V., 2018)Repetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant ... -
The brain protective effect of rtms (repetitive transcranial magnetic stimulation) in depression: A mini-review in animal studies
Yuluğ, Burak; Hanoğlu, Lütfü; Tavlı, Ahmet Mithat; Yılmaz Helvacı, Nesrin; Kılıç, Ertuğrul (Bentham Science Publishers, 2016)There are rapidly replicating human data suggesting the therapeutic and neurorestorative role of repetitive transcranial magnetic stimulation (rTMS) in clinical depression. However there are only limited experimental studies ... -
Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?
Günal, Mehmet Yalçın; Şahinler Ayla, Sibel; Çaglayan, Berrak; Beker, Mustafa Çağlar; Bedri, Nejda; Aslan, İpek Bilge; Özdemir, Ekrem Musa; Kılıç, Ertuğrul; Yeşilada, Elif (Comenius University, 2021)OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, ... -
CCL11 differentially affects post-stroke brain injury and neuroregeneration in mice depending on age
Lieschke, Simone; Zechmeister, Bozena; Haupt, Matteo; Zheng, Xuan; Jin, Fengyan; Hein, Katharina; Weber, Martin S.; Hermann, Dirk M.; Bähr, Mathias; Kılıç, Ertuğrul; Doeppner, Thorsten R. (MDPI, 2020)CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ... -
CDNF ve MANF büyüme faktörlerinin optik sinir hasarı sonrası retinal gangliyon hücre hasarına olan etki ve mekanizmaları
Karaçay, Reyda (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Sinir sisteminde nöronal sağkalım, nörogenez ve plastisite gibi önemli görevleri olan nörotrofik faktörlerin varlığı nöronal hücreler için vazgeçilmezdir. Nörotrofik faktörlerin yokluğu hatta seviyelerindeki farklılıklar ... -
CDNF ve manf nörotrofik faktörlerinin iskemi sonrası beyin plastisitesi ve onarımı üzerine olan etkileri
Çağlayan, Ahmet Burak (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Küçük protein yapıları ile nörotrofik faktörler, nöronların gelişimi sırasındaki rollerinin yanı sıra beyinde nöronların hayatta kalımı, nörogenez ve sinaptik bağlantıların korunmasında da mutlak rol oynamaktadırlar. ... -
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ... -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ...
