Browsing by Author "Hermann, Dirk Matthias"
Now showing items 1-11 of 11
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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice
Zheng, Xuan; Zhang, Lin; Kuang, Yaoyun; Venkataramani, Vivek; Jin, Fengyan; Hein, Katharina; Zafeiriou, Maria Patapia; Lenz, Christof; Moebius, Wiebke; Kılıç, Ertuğrul; Hermann, Dirk Matthias; Weber, Martin S.; Urlaub, Henning; Zimmermann, Wolfram Hubertus; BäHR, Mathias; Doeppner, Thorsten Roland (Springer, 2021)Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, ... -
Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice (vol 12, pg 185, 2021)
Zheng, Xuan; Zhang, Lin; Kuang, Yaoyun; Venkataramani, Vivek; Jin, Fengyan; Hein, Katharina; Zafeiriou, Maria Patapia; Lenz, Christof; Moebius, Wiebke; Kılıç, Ertuğrul; Hermann, Dirk Matthias; Weber, Martin S.; Urlaub, Henning; Zimmermann, Wolfram Hubertus; BäHR, Mathias; Doeppner, Thorsten Roland (Springer, 2022)In the version of this article initially published, there were errors on pages 5 and 6. -
The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration
Doeppner, Thorsten Roland; Pehlke, Jens; Kaltwasser, Britta; Schlechter, Jana; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Nature Publishing Group, 2015)Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Altunay, Serdar; Özbay, Elif; Ateş, Nilay; Keleştemur, Taha; Çağlayan, Berrak; Kılıç, Ülkan; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Ateş, Nilay; Çağlayan, Aysun; Balçıkanlı, Zeynep; Sertel, Elif; Beker, Mustafa Çağlar; Dilsiz, Pelin; Çağlayan, Ahmet Burak; Çelik, Süleyman; Daşdelen, Muhammed Furkan; Çağlayan, Berrak; Yiğitbaşı, Türkan; Özbek, Hanefi; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Post-stroke transplantation of adult subventricular zone derived neural progenitor cells - A comprehensive analysis of cell delivery routes and their underlying mechanisms
Doeppner, Thorsten Roland; Kaltwasser, Britta; Teli, Mahesh; Sánchez-Mendoza, Eduardo; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Academic Press, 2015)With neuroprotective approaches having failed until recently, current focus on experimental stroke research has switched towards manipulation of post-ischemic neuroregeneration. Transplantation of subventricular zone (SVZ) ... -
Sustained neurological recovery induced by resveratrol is associated with angioneurogenesis rather than neuroprotection after focal cerebral ischemia
Hermann, Dirk Matthias; Zechariah, Anil; Kaltwasser, Britta; Bosche, Bert; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Doeppner, Thorsten Roland (Academic Press, 2015)According to the French paradox, red wine consumption reduces the incidence of vascular diseases even in the presence of highly saturated fatty acid intake. This phenomenon is widely attributed to the phytoalexin resveratrol, ... -
The unconventional growth factors cerebral dopamine neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor promote post-ischemic neurological recovery, perilesional brain remodeling, and lesion-remote axonal plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Sertel Evren, Elif; Çağlayan, Berrak; Kılıç, Ülkan; Ateş, Nilay; Çağlayan, Aysun; Daşdelen, Muhammed Furkan; Doeppner, Thorsten Roland; Saarma, Mart; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2023)Considerable efforts are currently made to develop strategies that boost endogenous recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic factors are attractive candidates that capitalize ...
