Browsing by Author "Güzel, Mustafa"
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Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)
Lee, Eunmi; Ouzounova, Maria D.; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John K.; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan (Nature Publishing Group, 2019)Following publication of this article the authors noted that the Acknowledgments section had been omitted. This section should read as follows. -
Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines
Onur Sucu, Bilgesu; Koç, Elif Beyza; Şavluğ İpek, Özgecan; Mirat, Afranur; Almas, Furkan; Güzel, Melike Aybala; Doğan, Berna; Uludağ, Damla; Karakaş, Nihal; Durdağı, Serdar; Güzel, Mustafa (Elsevier Inc., 2022)Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of the deadliest cancers. The current treatment plans for GBM remains to be ineffective because of its rapid progress and inability of ... -
Design and synthesis of novel cylopentapyrazoles bearing 1,2,3-thiadiazole moiety as potent antifungal agents
Giray, Betül; Karadağ, Ayşe Esra; Şavluğ İpek, Özgecan; Pekel, Hanife; Güzel, Mustafa; Başpınar Küçük, Hatice (Elsevier, 2020)In drug-resistant phytopathogenic fungi, there has been extensive research on microbiological and antifungal drug development. In this study, a novel series of cylopentapyrazole bearing a 1,2,3-thiadiazole ring 2a-e were ... -
Essential parameters and risk factors of the patients for diabetes care and treatment
Bener, Abdulbari; Keskin, Fatma Ela; Kurtuluş, Eda Merve; Güzel, Mustafa; Çekirdekçi, Elif İjlal; Kadıoğlu, Pınar; Konukoğlu, Dildar; Öztürk, Mustafa (Elsevier Ltd, 2017)Aim: The aim was to explore the association between Type 2 Diabetes Mellitus [T2DM] treatment satisfactions of patients regarding their socio-economic, life-style, history medication and clinical outcome in a Turkish ... -
Ghrelin o-açil transferaz inhibisyonunun obezite üzerine etkisinin araştırılması
Burul, Şerife Betül (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Obezite, hiperlipidemi, Tip-2 DM, hipertansiyon ve koroner kalp hastalıklarına sebep olan kronik bir hastalıktır ve son yıllarda dünyada ve ülkemizde hasta sayısı hızlı bir şekilde artmaktadır. Obezite, beraberinde ekonomik ... -
Identification and in vitro bioactivity screening of some marine-derived fungi from Turkish coastlines
Heydari, Hajar; Konuklugil, Belma; Giray, Betül; Karadağ, Ayşe Esra; Güzel, Mustafa (Cahiers de Biologie Marine, 2020)The marine environment represents a great variety of conditions of pressure, temperature, salinity, and light depending on depth, latitude and interactions with the continental shelf. These extreme and variable conditions ... -
Lamotrigine derivatives-synthesis, anti-cancer, and anti-MDR-bacterial activities
Khan, Mahroza Kanwal; Siddiqui, Hina; Sharif, Ruby; Güzel, Mustafa; Wahab, Atia-tul; Yousuf, Sammer; Choudhary, M. Iqbal (Elsevier B.V., 2022)A new series of quaternary ammonium salts 3–21 of lamotrigine (6-(2, 3-dichlorophenyl)-1, 2, 4-triazine-3, 5-diamine) was synthesized via N-alkylation of lamotrigine using different benzyl bromides. The new analogues were ... -
The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies
Durdağı, Serdar; Avşar, Timuçin; Orhan, Müge Didem; Serhatlı, Müge; Balcıoğlu, Bertan Koray; Öztürk, Hasan Ümit; Kayabölen, Alişan; Çetin, Yüksel; Aydınlık, Şeyma; Bağcı-Önder, Tuğba; Tekin, Şaban; Demirci, Hasan; Güzel, Mustafa; Akdemir, Atilla; Çalış, Şeyma; Oktay, Lalehan; Tolu, İlayda; Bütün, Yaşar Enes; Erdemoğlu, Ece; Olkan, Alpsu; Tokay, Nurettin; Işık, Şeyma; Özcan, Ayşenur; Acar, Elif; Büyükkılıç, Şehriban; Yumak, Yeşim (Cell Press, 2022)Small molecule inhibitors have previously been investigated in different studies as possible therapeutics in the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In the current drug repurposing ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
Keskin, Elif; Üçışık, Mehmet Hikmet; Sucu, Bilgesu Onur; Güzel, Mustafa (MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
Başpınar Küçük, Hatice; Kantürk, Gökhan; Yerlikaya, Şerife; Yıldız, Tülay; Şentürk, Ahmet Mesut; Güzel, Mustafa (Elsevier B. V., 2022)In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed, synthesized, and evaluated for their anticancer activity. The structure of these compounds were characterized by IR, 1H and 13C NMR, mass ... -
Özgün metil jasmonat mimetiklerinin hücre canlılığı üzerine etkinliklerinin insan akciğer ve yumurtalık kanser hatlarında incelenmesi
Yazıcı, Büşra Emine (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Kanser dünyada olduğu gibi ülkemizde de yaygın hastalıkların başında gelmektedir. Warburg hipotezine göre, kanser hücrelerinin enerji tüketimi normal hücrelerden farklıdır. Kanser hücreleri normal hücrelerden farklı olarak ... -
The pleiotropic effects of TNF alpha in breast cancer subtypes is regulated by TNFAIP3/A20 (vol 38, pg 469, 2018)
Lee, Eunmi; Ouzounova, Maria; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John Kenneth; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan (Nature Publishing Group, 2019)Following publication of this article the authors noted that the Acknowledgments section had been omitted. This section should read as follows. -
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
Lee, Eunmi; Ouzounova, Maria; Piranlıoğlu, Raziye; Ma, Minh Thu; Güzel, Mustafa; Marasco, Daniela; Chadli, Ahmed; Gestwicki, Jason E.; Cowell, John Kenneth; Wicha, Max S.; Hassan, Khaled A.; Korkaya, Hasan (Nature Publishing Group, 2019)TNF alpha is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNF alpha exerts ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
Uludağ, Damla; Bay, Sadık; Onur Sucu, Bilgesu; Şavluğ İpek, Özgecan; Mohr, Thomas; Güzel, Mustafa; Karakaş, Nihal (Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
Piranlıoğlu, Raziye; Lee, EunMi; Ouzounova, Maria; Bollag, Roni J.; Vinyard, Alicia H.; Arbab, Ali S.; Marasco, Daniela; Güzel, Mustafa; Cowell, John Kenneth; Thangaraju, Muthushamy; Chadli, Ahmed; Hassan, Khaled A.; Wicha, Max S.; Celis, Esteban; Körkaya, Hasan (Nature Publishing Group, 2019)Although clinically apparent metastasis is associated with late stages of cancer development, micro-metastatic dissemination may be an early event. However, the fate of these early disseminated tumor cells (DTC) remains ... -
Synthesis of novel methyl jasmonate derivatives and evaluation of their biological activity in various cancer cell lines
Onur Sucu, Bilgesu; Savluğ İpek, Özgecan; Özdatlı Kurtuluş, Şükran; Yazıcı, Büşra Emine; Karakaş, Nihal; Güzel, Mustafa (Academic Press Inc Elsevier Science, 2019)Warburg hypothesized that the energy consumption of cancer cells is different than the normal cells. When compared to normal conditions, cancer cells do not undergo tricarboxylic acid (TCA) cycle therefore resulting in ... -
Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acy1-2,3-dihydropyridones
Güzel, Mustafa; Watts, Joshua; McGilvary, Matthew; Wright, Marcus; Kiren, Sezgin (Pergamon-Elsevier Science, 2015)We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acy1-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative ... -
Welcome message
Yiğitbaşı, Türkan; Güzel, Mustafa (De Gruyter Open Ltd, 2021)We are pleased to announce that the 3rd International Cancer and Ion Channels Congress (CANCERION-2021) will be held virtually during 16th -18th September 2021. The organization is under the auspices of the Minister of ...
