Browsing by Author "Elibol, Birsen"
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Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
Effects of melatonin and memantine administration on the learning and memory performances of hypoxic juvenile rat pups
Elibol, Birsen; Şahbaz, Çiğdem; Eyüboğlu, Siğnem; Çevreli, Burcu; Kılıç, Ülkan; Kılıç, Ertuğrul (Yerküre Tanıtım ve Yayıncılık Hizmetleri A.Ş., 2020)Objective: Herein, we aimed to investigate the long-term effects of neonatal hypoxia and the potential protective role of melatonin and memantine on the learning and memory. Methods: Seven-day-old rat underwent right carotid ... -
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis
Kılıç, Ülkan; Gök, Özlem; Elibol, Birsen; Uysal, Ömer; Bacaksız, Ahmet (Wiley, 2015)Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and are used to reduce the risk of coronary artery disease (CAD) due to their pleiotropic effects. Recently, greater focus has been placed on the role ... -
Inflammatory cytokines are in action: Brain plasticity and recovery after brain ischemia due to delayed melatonin administration
Kılıç, Ülkan; Elibol, Birsen; Beker, Merve; Altuğ Tasa, Burcugül; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yılmaz, Bayram; Kılıç, Ertuğrul (W.B. Saunders, 2021)Objectives: Post-ischemic inflammation leads to apoptosis as an indirect cause of functional disabilities after the stroke. Melatonin may be a good candidate for the stroke recovery because of its anti-inflammatory effects. ... -
A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human
Kılıç, Ülkan; Gök, Özlem; Erenberk, Ufuk; Dündaröz, Mehmet Ruşen; Torun, Emel; Küçükardalı, Yaşar; Elibol, Birsen; Uysal, Ömer; Dündar, Tolga Turan (Public Library of Science, 2015)Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules ... -
SIRT1 gene variants are related to risk of childhood obesity
Kılıç, Ülkan; Gök, Özlem; Elibol, Birsen; Özgen, İlker Tolga; Erenberk, Ufuk; Uysal, Ömer; Dündaröz, Mehmet Ruşen (Springer, 2015)Obesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, ... -
Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia
Kılıç, Ülkan; Elibol, Birsen; Uysal, Ömer; Kılıç, Ertuğrul; Yuluğ, Burak; Sayın Şakul, Arzu; Babacan Yıldız, Gülşen (Pergamon Elsevier Science Ltd, 2018)Sirtuins have gained considerable attention as epigenetic regulators for slowing aging and age-related disorders. The growing association between neurodegeneration and inflammation has led researchers to investigate ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ...
