Browsing by Author "Doeppner, Thorsten Roland"
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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition
Doeppner, Thorsten Roland; Kaltwasser, Britta; Schlechter, Jana; Jaschke, J.; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias; Weise, Jens (Nature Publishing Group, 2015)Although cellular prion protein (PrPc) has been suggested to have physiological roles in neurogenesis and angiogenesis, the pathophysiological relevance of both processes remain unknown. To elucidate the role of PrPc in ... -
Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice
Zheng, Xuan; Zhang, Lin; Kuang, Yaoyun; Venkataramani, Vivek; Jin, Fengyan; Hein, Katharina; Zafeiriou, Maria Patapia; Lenz, Christof; Moebius, Wiebke; Kılıç, Ertuğrul; Hermann, Dirk Matthias; Weber, Martin S.; Urlaub, Henning; Zimmermann, Wolfram Hubertus; BäHR, Mathias; Doeppner, Thorsten Roland (Springer, 2021)Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs only, ... -
The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration
Doeppner, Thorsten Roland; Pehlke, Jens; Kaltwasser, Britta; Schlechter, Jana; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Nature Publishing Group, 2015)Cerebral ischemia stimulates N-methyl-D-aspartate receptors (NMDARs) resulting in increased calcium concentration and excitotoxicity. Yet, deactivation of NMDAR failed in clinical studies due to poor preclinical study ... -
Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3 beta inhibition-independent pathways
Doeppner, Thorsten Roland; Kaltwasser, Britta; Sanchez-Mendoza, Eduardo H.; Çağlayan, Ahmet Burak; Baehr, Mathias; Hermann, Dirk M. (Sage Publication Inc., 2017)Lithium promotes acute poststroke neuronal survival, which includes mechanisms that are not limited to GSK3 inhibition. However, whether lithium induces long-term neuroprotection and enhanced brain remodeling is unclear. ... -
Neuroprotective effect of lithium in cold- induced traumatic brain injury in mice
Çiftci, Elvan; Karaçay, Reyda; Çağlayan, Aysun; Altunay, Serdar; Ateş, Nilay; Altıntaş, Mehmet Özgen; Doeppner, Thorsten Roland; Yuluğ, Burak; Kılıç, Ertuğrul (Elsevier, 2020)Apart from its well-established therapeutic activity on bipolar disorder and depression, lithium exerts neuroprotective activity upon neurodegenerative disorders, such as traumatic brain injury (TBI). However, the cellular ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Ateş, Nilay; Çağlayan, Aysun; Balçıkanlı, Zeynep; Sertel, Elif; Beker, Mustafa Çağlar; Dilsiz, Pelin; Çağlayan, Ahmet Burak; Çelik, Süleyman; Daşdelen, Muhammed Furkan; Çağlayan, Berrak; Yiğitbaşı, Türkan; Özbek, Hanefi; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Post-stroke transplantation of adult subventricular zone derived neural progenitor cells - A comprehensive analysis of cell delivery routes and their underlying mechanisms
Doeppner, Thorsten Roland; Kaltwasser, Britta; Teli, Mahesh; Sánchez-Mendoza, Eduardo; Kılıç, Ertuğrul; Baehr, Mathias; Hermann, Dirk Matthias (Academic Press, 2015)With neuroprotective approaches having failed until recently, current focus on experimental stroke research has switched towards manipulation of post-ischemic neuroregeneration. Transplantation of subventricular zone (SVZ) ... -
Sustained neurological recovery induced by resveratrol is associated with angioneurogenesis rather than neuroprotection after focal cerebral ischemia
Hermann, Dirk Matthias; Zechariah, Anil; Kaltwasser, Britta; Bosche, Bert; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Doeppner, Thorsten Roland (Academic Press, 2015)According to the French paradox, red wine consumption reduces the incidence of vascular diseases even in the presence of highly saturated fatty acid intake. This phenomenon is widely attributed to the phytoalexin resveratrol, ... -
Systemic proteasome inhibition induces sustained post-stroke neurological recovery and neuroprotection via mechanisms involving reversal of peripheral immunosuppression and preservation of blood-brain-barrier integrity
Doeppner, Thorsten Roland; Kaltwasser, Britta; Kuckelkorn, Ulrike; Henkelein, Petra; Bretschneider, Eva; Kılıç, Ertuğrul; Hermann, Dirk M. (Springer, 2016)In view of its profound effect on cell survival and function, the modulation of the ubiquitin-proteasome-system has recently been shown to promote neurological recovery and brain remodeling after focal cerebral ischemia. ...
