Browsing by Author "Doeppner, Thorsten R."
Now showing items 1-14 of 14
-
Adipose-derived mesenchymal stem cells reduce autophagy in stroke mice by extracellular vesicle transfer of miR-25
Kuang, Yaoyun; Zheng, Xuan; Zhang, Lin; Ai, Xiaoyu; Venkataramani, Vivek; Kılıç, Ertuğrul; Hermann, Dirk M.; Majid, Arshad; Baehr, Mathias; Doeppner, Thorsten R. (Taylor & Francis Ltd, 2020)Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has not yet been identified. To investigate ... -
CCL11 differentially affects post-stroke brain injury and neuroregeneration in mice depending on age
Lieschke, Simone; Zechmeister, Bozena; Haupt, Matteo; Zheng, Xuan; Jin, Fengyan; Hein, Katharina; Weber, Martin S.; Hermann, Dirk M.; Bähr, Mathias; Kılıç, Ertuğrul; Doeppner, Thorsten R. (MDPI, 2020)CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ... -
Conditioned medium derived from neural progenitor cells induces long-term post-ischemic neuroprotection, sustained neurological recovery, neurogenesis, and angiogenesis
Doeppner, Thorsten R.; Traut, Viktorija; Heidenreich, Alexander; Kaltwasser, Britta; Bosche, Bert; Bahr, Mathias; Hermann, Dirk M. (Springer, 2017)Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic ... -
Developing a novel tool to assess the ability to self-administer medication - A systematic evaluation of patients' video recordings in the ABLYMED study
Luegering, Anneke; Langner, Robert; Wilm, Stefan; Doeppner, Thorsten R.; Hermann, Dirk M.; Frohnhofen, Helmut; Gronewold, Janine (Frontiers Media S.A., 2023)Background: Older people often experience medication management problems due to multimorbidity, polypharmacy and medication complexity. There is often a large gap between patients' self-reported and actual abilities to ... -
Emerging roles of extracellular vesicle-associated non-coding RNAs in hypoxia: Insights from cancer, myocardial infarction and ischemic stroke
Hermann, Dirk M.; Xin, Wenqiang; Baehr, Mathias; Giebel, Bernd; Doeppner, Thorsten R. (Ivyspring International Publisher, 2022)Hypoxia is a central pathophysiological component in cancer, myocardial infarction and ischemic stroke, which represent the most common medical conditions resulting in long-term disability and death. Recent evidence suggests ... -
Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-beta/Smad2/3 pathway
Zhang, Lin; Wei, Wei; Ai, Xiaoyu; Kılıç, Ertuğrul; Hermann, Dirk M.; Venkataramani, Vivek; Baehr, Mathias; Doeppner, Thorsten R. (Springer Nature, 2021)Systemic transplantation of oxygen-glucose deprivation (OGD)-preconditioned primary microglia enhances neurological recovery in rodent stroke models, albeit the underlying mechanisms have not been sufficiently addressed. ... -
In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model
Kelmanson, Ilya V.; Shokhina, Arina G.; Kotova, Daria A.; Pochechuev, Matvei S.; Ivanovaa, Alexandra D.; Kostyuka, Alexander I.; Panova, Anastasiya S.; Borodinova, Anastasia A.; Solotenkovc, Maxim A.; Stepanov, Evgeny A.; Raevskiia, Roman I.; Moshchenko, Aleksandr A.; Pak, Valeriy V.; Ermakova, Yulia G.; van Belle, Gijsbert J.C.; Tarabykin, Viktor; Balaban, Pavel M.; Fedotov, Ilya V.; Fedotov, Andrei B.; Conrad, Marcus; Bogeski, Ivan; Katschinski, Dörthe M.; Doeppner, Thorsten R.; Bähr, Mathias; Zheltikov, Aleksei M.; Belousov, Vsevolod V.; Bilan, Dmitry S. (Elsevier B.V., 2021)Ischemic cerebral stroke is one of the leading causes of death and disability in humans. However, molecular processes underlying the development of this pathology remain poorly understood. There are major gaps in our ... -
Inhibition of fatty acid synthesis aggravates brain injury, reduces blood-brain barrier integrity and impairs neurological recovery in a murine stroke model
Janssen, Lisa; Ai, Xiaoyu; Zheng, Xuan; Wei, Wei; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Wang, Ya-chao; Hermann, Dirk M.; Venkataramani, Vivek; Baehr, Mathias; Doeppner, Thorsten R. (Frontiers Media SA, 2021)Inhibition of fatty acid synthesis (FAS) stimulates tumor cell death and reduces angiogenesis. When SH-SY5Y cells or primary neurons are exposed to hypoxia only, inhibition of FAS yields significantly enhanced cell injury. ... -
Ischemic post-conditioning induces post-stroke neuroprotection via Hsp70-mediated proteasome inhibition and facilitates neural progenitor cell transplantation
Doeppner, Thorsten R.; Doehring, Maria; Kaltwasser, Britta; Majid, Arshad; Lin, Fengyan; Bahr, Mathias; Kılıç, Ertuğrul; Hermann, Dirk M. (Humana Press Inc, 2017)In view of the failure of pharmacological therapies, alternative strategies promoting post-stroke brain repair are needed. Post-conditioning is a potentially promising therapeutic strategy, which induces acute neuroprotection ... -
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation
Haupt, Matteo; Zheng, Xuan; Kuang, Yaoyun; Lieschke, Simone; Janssen, Lisa; Bosche, Bert; Jin, Fengyan; Hein, Katharina; Kılıç, Ertuğrul; Venkataramani, Vivek; Hermann, Dirk M.; Bahr, Mathias; Doeppner, Thorsten R. (Wiley, 2021)Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further ... -
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Doeppner, Thorsten R.; Coman, Cristin; Burdusel, Daiana; Ancuta, Diana Larisa; Brockmeier, Ulf; Pirici, Daniel Nicolae; Kuang Yaoyun; Hermann, Dirk M.; Popa Wagner, Aurel (Impact Journals LLC, 2022)Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ... -
Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity by NF-kappa B (Nuclear Factor-kappa B)-dependent regulation of ABCB1 (ATP-Binding Cassette Transporter B1) in stroke mice
Zhang, Lin; Graf, Irina; Kuang, Yaoyun; Zheng, Xuan; Haupt, Matteo; Majid, Arshad; Kılıç, Ertuğrul; Hermann, Dirk M.; Psychogios, Marios-Nikos; Weber, Martin S.; Ochs, Jasmin; Baehr, Mathias; Doeppner, Thorsten R. (Lippincott Williams & Wilkins, 2021)Objective: Extracellular vesicles (EVs) derived from neural progenitor cells enhance poststroke neurological recovery, albeit the underlying mechanisms remain elusive. Since previous research described an enhanced poststroke ... -
Neuroprotective strategies for ischemic stroke—Future perspectives
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (MDPI, 2023)Ischemic stroke is the main cause of death and the most common cause of acquired physical disability worldwide. Recent demographic changes increase the relevance of stroke and its sequelae. The acute treatment for stroke ... -
Quest for quality in translational stroke research––a new dawn for neuroprotection?
Haupt, Matteo; Gerner, Stefan T.; Bähr, Mathias; Doeppner, Thorsten R. (Multidisciplinary Digital Publishing Institute, 2022)Despite tremendous progress in modern‐day stroke therapy, ischemic stroke remains a disease associated with a high socioeconomic burden in industrialized countries. In light of demo-graphic change, these health care costs ...
