Browsing by Author "Chang, Joshua"

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Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability

Kubat Öktem, Elif; Mruk, Karen; Chang, Joshua; Akın, Ata; R. Kobertz, William; Brown Jr, Robert H. (Springer, 2016)

Firing patterns of a mammalian neuron in response to changes in Nav conductance induced by hSOD1A4V. a At the baseline (see Methods), there is no predicted spontaneous firing as modeled using NEURON software (left; resting ...
Mutant SOD1 protein increases Na(v)1.3 channel excitability

Kubat Öktem, Elif; Mruk, Karen; Chang, Joshua; Akın, Ata; Kobertz, William R.; Brown, Robert H., Jr. (Springer, 2016)

Amyotrophic lateral sclerosis (ALS) is a lethal paralytic disease caused by the degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in the gene encoding copper/zinc superoxide dismutase ...