Browsing by Author "Bülbül, Muhammet Volkan"
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Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells
Bülbül, Muhammet Volkan; Özbek, Hanefi; Bahadır Acıkara, Özlem; Özbilgin, Serkan; Ergene Öz, Burçin; Kurtul, Ekin; Keskin, İlknur (Ondokuz Mayıs University, 2018)In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis ... -
Bazı endemik onobrychis türlerinin kolon kanseri hücreleri üzerindeki etkilerinin incelenmesi
Bülbül, Muhammet Volkan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Kanser türlerinin dağılımı ülkelere göre farklılık göstermekle birlikte Kolorektal Kanserler (KRK) gelişmiş ülkelerde en önemli sağlık problemlerinden biri olarak görülmektedirler. Ülkemizde Sağlık Bakanlığı verilerine ... -
Benzotriazole-oxadiazole hybrid compounds: Synthesis, anticancer activity, molecular docking and ADME profiling studies
Mermer, Arif; Bülbül, Muhammet Volkan; Kalender, Semiha Mervenur; Keskin, İlknur; Tüzün, Burak; Eyüpoğlu, Ozan Emre (Elsevier B.V., 2022)Herein the designed novel benzotriazole-oxadiazole hybrid compounds were synthesized using both conventional method and ultrasound sonication (US) as an environmentally friendly method. It was observed that the US method ... -
Chronic unpredictable stress disturbs the blood-testis barrier affecting sperm parameters in mice
Kolbaşı, Bircan; Bülbül, Muhammet Volkan; Karabulut, Seda; Erdem Altun, Ceren; Çakıcı, Çağrı; Ülfer, Gözde; Müdok, Tangül; Keskin, İlknur (Elsevier Ltd, 2021)Research question: Does chronic stress affect the key proteins and sperm parameters of the blood & ndash;testis barrier (BTB)? Design: C57Bl/6 mice were divided into two groups: a non-treated control group and a chronic ... -
Effects of gallic acid on endometrial cancer cells in two and three dimensional cell culture models
Bülbül, Muhammet Volkan; Karabulut, Seda; Kalender, Mervenur; Keskin, İlknur (Asian Pacific Organization for Cancer Prevention, 2021)Background and Aim: Cell culture studies are an indispensable tools used to understand basic physiological, biophysical and biomolecular mechanisms. Although traditional two-dimensional (2D) cell culture models are more ... -
Fresh versus frozen blastocyst transfer outcomes deriven from the same ICSI cycle in male factor infertility
Karabulut, Seda; Kutlu, Pelin; Korkmaz, Oya; Bülbül, Muhammet Volkan; Keskin, İlknur (IMR Press Limited, 2021)The aim of this study was to investigate the clinical outcomes of fresh and frozen-thawed blastocyst transfer deriven from the same ICSI cycle because of male infertility. 2372 couples undergoing a total of 5075 ICSI cycles ... -
In 2D and 3D cell culture models, effects of endothelial cells on E-cadherin / β-catenin expression levels and spheroid sizes in ishikawa cells
Kalender, Mervenur; Bülbül, Muhammet Volkan; Kolbaşı, Bircan; Keskin, İlknur (Asian Pacific Organization for Cancer Prevention, 2022)Increasing evidence shows that three dimensional cell culture models better reflect the in vivo tumor microenvironment than two dimensional cell culture models. Co-culture models are ideal cell culture models for understanding ... -
Mesenchymal stem cell applications in polycystic ovary syndrome treatment
Bülbül, Muhammet Volkan; Yıldırım, Berna; Kolbaşı, Bircan; Keskin, İlknur (Ondokuz Mayıs Üniversitesi, 2021)Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under ...
