Browsing by Author "Altunay, Serdar"
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Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
Allyl isothiocyanate enhances brain neuronal plasticity proteins via inhibition of inflammation proteins
Juturu, Vijaya; Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Tuzcu, Mehmet; Erten, Füsun; Günal, Mehmet Yalçın; Altunay, Serdar; Orhan, Cemal; Şahin, Kazım (Lippincott Williams & Wilkins, 2018)… -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ... -
Diyet restriksiyonu ile ön koşullandırma tekniğinin fare beyin felci modelindeki nöroprotektif etkisinin araştırılması
Altunay, Serdar (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Sağlığımızın devamlılığını korumak için önemli bir olgu olan beslenme, aynı zamanda sağlık için tehdit de oluşturabilmektedir. Beslenmedeki bozukluklar sonucu, çeşitli hastalıklara yakalanma riskleri arttığı gibi varolan ... -
Dual action of exosomes derived from in vitro A beta toxicity model: The role of age for pathological response
Beker, Merve; Günay, Necmeddin; Sarıkamış, Bahar; Kalkan Çakmak, Rabia; Erçin, Nilüfer; Altıntaş, Mehmet Özgen; Altunay, Serdar; Beker, Mustafa Çağlar; Sarı Ak, Duygu; Kılıç, Ülkan (Elsevier Ireland Ltd, 2023)Exosomes released from different cell types of the central nervous system play an essential role in the patho-genesis of Alzheimer's disease (AD). In this study, we aimed to create an animal model by injecting exosomes ... -
Effects of neurotrophic factors cdnf and manf on brain plasticity and repair after brain ischemia
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Altunay, Serdar; Dalay, Arman; Dilden, Aysun; Sertel, Elif; Keleştemur, Taha; Yalçın, Esra; Kılıç, Ülkan; Saarma, Mart; Kılıç, Ertuğrul (Wiley-Blackwell, 2016)... -
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins
Beker, Merve; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Altunay, Serdar; Karaçay, Reyda; Dalay, Arman; Altıntaş, Mehmet Özgen; Torun Köse, Gamze; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2020)Owing to its potent longterm neuroprotective and neurorestorative properties, glial cell line-derived neurotrophic factor (GDNF) is currently studied in neurodegenerative disease clinical trials. However, little is known ... -
Neuroprotective effect of lithium in cold- induced traumatic brain injury in mice
Çiftci, Elvan; Karaçay, Reyda; Çağlayan, Aysun; Altunay, Serdar; Ateş, Nilay; Altıntaş, Mehmet Özgen; Doeppner, Thorsten Roland; Yuluğ, Burak; Kılıç, Ertuğrul (Elsevier, 2020)Apart from its well-established therapeutic activity on bipolar disorder and depression, lithium exerts neuroprotective activity upon neurodegenerative disorders, such as traumatic brain injury (TBI). However, the cellular ... -
Normobaric oxygen treatment improves neuronal survival functional recovery and axonal plasticity after newborn hypoxia-ischemia
Keleştemur, Taha; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Çağlayan, Berrak; Altunay, Serdar; Kutlu, Selim; Kılıç, Ertuğrul (Elsevier, 2020)Background: Newborn hypoxia ischemia (HI) is one of the most prevalent cases in the emergency and can result from fetal hypoxia during delivery. In HI, restricted blood supply to the fetal brain may cause epilepsy or mental ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Altunay, Serdar; Özbay, Elif; Ateş, Nilay; Keleştemur, Taha; Çağlayan, Berrak; Kılıç, Ülkan; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
REV-ERBa ve REV-ERBβ'nın akut beyin hasarı sonrası rolünün incelenmesi
Altunay, Serdar (İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Dünyada ölüm nedenleri bakımından ikinci sırada yer alan inmenin insidansı sirkadiyen bir dağılım göstermektedir. Tüm fizyolojik durumlarımızı düzenleyen sirkadiyen ritmin hem inmenin tetiklenmesine hem de inme sonrasında ... -
The role of repetative transcranial magnetic stimulation after focal cerebral ischemia
Çağlayan, Ahmet Burak; Yalçın, Esra; Altunay, Serdar; Sertel, Elif; Dilden, Aysun; Karaçay, Reyda; Beker, Mustafa Çağlar; Keleştemur, Taha; Çağlayan, Berrak; Kutlu, Selim; Kılıç, Ülkan; Kılıç, Ertuğrul (Wiley, 2017)...
