Browsing by Author "Akkaya, Semih"
Now showing items 1-6 of 6
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Are we using slow-acting symptomatic chondroprotective drugs conscious enough?
Gümüştaş, Seyit Ali; Öznam, Kadir; Mutlu, Çağrı Ata; Kaya, Yasin Emre; Yılmaz, İbrahim; İşyar, Mehmet; Yıldırım Güzelant, Aliye; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Bentham Open, 2017)Background: Osteochondral injuries constitute an entity that is widespread and can be seen in patients of all ages. Actual treatment modalities aim to relieve pain, obtain full range of movement of the joint, and improve ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Can a biodegradable implanted bilayered drug delivery system loaded with BMP-2/BMP-12 take an effective role in the biological repair process of bone-tendon injuries? A preliminary report
Kömür, Baran; Akyuva, Yener; Karaslan, Numan; İşyar, Mehmet; Gümüştaş, Seyit Ali; Yılmaz, İbrahim; Akkaya, Semih; Şirin, Duygu Yaşar; Mutlu, Çağri Ata; Batmaz, Ahmet Güray; Güler, Olcay; Mahiroğulları, Mahir (Hindawi Ltd, 2017)Background. Use of biodegradable and biocompatible materials in the orthopedic surgery is gaining popularity. In this research, the rate of controlled release of a bilayered prototype biomaterial designed to promote ... -
Iopromide- and gadopentetic acid-derived preparates used in MR arthrography may be harmful to chondrocytes
Öznam, Kadir; Şirin, Duygu Yaşar; Yılmaz, İbrahim; Kaya, Yasin Emre; İşyar, Mehmet; Gümüştaş, Seyit Ali; Özbek, Hanefi; Akkaya, Semih; Kayhan, Arda; Mahiroğulları, Mahir (BMC, 2017)Background: Magnetic resonance arthrography, a procedure through which contrast agents containing gadolinium and/or iopromide are administered intra-articularly, has become a useful tool in musculoskeletal diagnosis. ... -
Is it possible to treat osteosarcoma using oligonucleotides confined into controlled release drug delivery systems?
Topuk, Savaş; Akyuva, Yener; Karaaslan, Numan; Mutlu, Çağri Ata; Yılmaz, İbrahim; İşyar, Mehmet; Şirin, Duygu Yaşar; Akkaya, Semih; Özbek, Hanefi; Mahiroğulları, Mahir (Bentham Science Publishers Ltd, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Is there a treatment protocol in which platelet-rich plasma is effective?
Yılmaz, İbrahim; Akkaya, Semih; İşyar, Mehmet; Batmaz, Ahmet Güray; Güler, Olcay; Öznam, Kadir; Uğras, Akın; Mahiroğulları, Mahir (Elsevier Science Bv, 2016)Aim: We aimed to reveal whether there are prospective suggestions for effective and standard platelet-rich plasma applications. Methods: We searched for clinical trials and traced all the references of incorporated documents. ...
