Browsing by Author "Akgül Çağlar, Tuba"
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Chemogenetic approaches to dissect the role of H2O2 in redox-dependent pathways using genetically encoded biosensors
Ghaffari Zaki, Asal; Erdoğan, Yusuf Ceyhun; Akgül Çağlar, Tuba; Eroğlu, Emrah (Portland Press Ltd, 2022)Chemogenetic tools are recombinant enzymes that can be targeted to specific organelles and tissues. The provision or removal of the enzyme substrate permits control of its biochemical activities. Yeast-derived enzyme D-amino ... -
Complexities of the chemogenetic toolkit: Differential mDAAO activation by D-amino substrates and subcellular targeting
Erdoğan, Yusuf Can; Altun, Hamza Yusuf; Seçilmiş, Melike; Ata, Büşra N.; Sevimli, Gülşah; Çokluk, Zeynep; Zaki, Asal Ghaffari; Sezen, Serap; Akgül Çağlar, Tuba; Sevgen, İlker; Steinhorn, Benjamin; Ai, Huiwang; Öztürk, Gürkan; Belousov, Vsevelod V.; Michel, Thomas; Eroğlu, Emrah (Elsevier Inc., 2021)A common approach to investigate oxidant-regulated intracellular pathways is to add exogenous H2O2 to living cells or tissues. However, the addition of H2O2 to the culture medium of cells or tissues approach does not ... -
Defining optimal enzyme and matrix combination for replating of human induced pluripotent stem cell-derived cardiomyocytes at different levels of maturity
Koç, Arzuhan; Şahoğlu Göktaş, Sevilay; Akgül Çağlar, Tuba; Çağavi, Esra (Elsevier Inc., 2021)Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational research. Depending on the maturity of cardiac cultures and the intended applications, ... -
Evaluation of the bilateral cardiac afferent distribution at the spinal and vagal ganglia by retrograde labeling
Akgül Çağlar, Tuba; Durdu, Zeynep Begüm; Turhan, M. U.; Günal, Mehmet Yalçın; Aydın, Mehmet Şerif; Öztürk, Gürkan; Çağavi, Esra (Elsevier, 2021)The identity of sensory neurons innervating the heart tissue and the extent of information reported to the brain via these neurons are poorly understood. In order to evaluate the multidimensional distribution and abundance ... -
Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo
Akgül Çağlar, Tuba; Günal, Mehmet Yalçın; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier Inc., 2021)Retrograde dyes are often used in basic research to investigate neuronal innervations of an organ. This article describes the experimental data on the application of retrograde dyes on the mouse heart in vivo and on the ... -
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier B.V., 2022)Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation ... -
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels (vol 53, 102319, 2022)
Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier, 2022)The authors regret that the cited reference list in the online PDF of this article contains a duplicate reference (Ref 34 and incomplete Ref 56). Ref 56 should read as follows. -
Patient-specific induced pluripotent stem cells for cardiac disease modeling
Çağavi, Esra; Akgül Çağlar, Tuba; Haider, Khawaja Husnain; Söztekin, Gökçe İlayda (Walter de Gruyter GMBH, 2019)Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via induction of pluripotency genes is one of the most influential scientific breakthroughs during the last decade. Behind this breakthrough ... -
Zero-valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering
Aydemir Sezer, Ümran; Öztürk Yavuz, Kevser; Örs, Gizem; Bay, Sadık; Aru, Başak; Söğüt, Oğuz; Akgül Çağlar, Tuba; Bozkurt, Mehmet Recep; Çağavi, Esra; Yanıkkaya Demirel, Gülderen; Sezer, Serdar; Karaca, Hüseyin (Wiley, 2020)Regeneration of nerve tissue is a challenging issue in regenerative medicine. Especially, the peripheral nerve defects related to the accidents are one of the leading health problems. For large degeneration of peripheral ...
