Browsing by Author "Şahin, Kazım"
Now showing items 1-13 of 13
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Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappa b pathways in traumatic brain injury in mice
Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Altunay, Serdar; Tuzcu, Mehmet; Erten, Füsun; Orhan, Cemal; Günal, Mehmet Yalçın; Yuluğ, Burak; Juturu, Vijaya; Şahin, Kazım (Springer, 2019)Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in young adults and children in the industrialized countries; however, there are presently no FDA approved therapies. TBI results in oxidative ... -
Allyl isothiocyanate enhances brain neuronal plasticity proteins via inhibition of inflammation proteins
Juturu, Vijaya; Çağlayan, Berrak; Kılıç, Ertuğrul; Dalay, Arman; Tuzcu, Mehmet; Erten, Füsun; Günal, Mehmet Yalçın; Altunay, Serdar; Orhan, Cemal; Şahin, Kazım (Lippincott Williams & Wilkins, 2018)… -
Cinnamon polyphenol extract exerts neuroprotective activity in traumatic brain injury in male mice
Yuluğ, Burak; Kılıç, Ertuğrul; Altunay, Serdar; Ersavaş, Cenk; Orhan, Cemal; Dalay, Arman; Tuzcu, Mehmet; Şahin, Nurhan; Juturu, Vijaya; Şahin, Kazım (Bentham Science Publishers Ltd, 2018)Introduction: Cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for the treatment of different disease conditions which are associated with inflammation and oxidative stress. ... -
Enhancement of cisplatin sensitivity in human cervical cancer: Epigallocatechin-3-gallate
Kılıç, Ülkan; Şahin, Kazım; Tuzcu, Mehmet; Başak, Nazlı; Orhan, Cemal; Elibol Can, Birsen; Kılıç, Ertuğrul; Şahin, Fikrettin; Küçük, Ömer (Frontiers Media, 2015)Cisplatin is one of the effective chemotherapeutics in the treatment of several types of cancers. However, in addition to the efforts against to its toxicity, the amelioration of cisplatin sensitivity is an important point ... -
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
Kılıç, Ülkan; Kılıç, Ertuğrul; Tuzcu, Zeynep; Tuzcu, Mehmet; Özercan, İbrahim; Yılmaz, Ökkeş; Şahin, Fikrettin; Şahin, Kazım (Biomed Central Ltd, 2013)Background: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited ... -
Protective effect of lutein/zeaxanthin isomers in traumatic brain injury in mice
Günal, Mehmet Yalçın; Şakul, Ayşe Arzu; Çağlayan, Ahmet Burak; Erten, Füsun; Durmaz Kurşun, Öznur Ece; Kılıç, Ertuğrul; Şahin, Kazım (Springer, 2021)Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert ... -
Protective effects of magnesium biotinate on propionic acid-induced autistic features in rats
Komorowski, James; Ojalvo, Sara; Orhan, Cemal; Erten, Füsun; Şahna, Engin; Kılıç, Ertuğrul; Şahin, Kazım (Wiley, 2020)Objective This study investigated the protective effects of magnesium biotinate (MgB) on propionic acid (PPA)-induced autistic features in rats. Background Biotin is involved in energy metabolism and various immune and ... -
Schiff base-poloxamer p85 combination prevents prostate cancer progression in c57/bl6 mice
Doǧan, Ayşegül; Demirci, Selami; Başak Türkmen, Neşe; Çağlayan, Ahmet Burak; Aydın, Safa; Telci, Dilek; Kılıç, Ertuğrul; Şahin, Kazım; Orhan, Cemal; Tuzcu, Mehmet; Doğan Ekici, Asiye Işın; Şahin, Fikrettin (Wiley, 2016)BACKGROUNDProstate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ...
