Browsing by Author "Şahin, Fikrettin"
Now showing items 1-17 of 17
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Antileishmanial activity of BNIPdaoct- and BNIPdanon-loaded emulsomes on leishmania infantum parasites
İşlek, Zeynep; Üçışık, Mehmet Hikmet; Keskin, Elif; Onur Sucu, Bilgesu; Gomes-Alves, Ana G.; Tomás, Ana M.; Güzel, Mustafa; Şahin, Fikrettin (Frontiers Media S.A., 2022)Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on ... -
Antiviral activity of different extracts of standardized propolis preparations against HSV
Demir, Sevda; Atayoğlu, Ali Timuçin; Galeotti, Fabio; Garzarella, Emanuele U.; Zaccaria, Vincenzo; Volpi, Nicola; Karagöz, Ali; Şahin, Fikrettin (International Medical Press Ltd, 2021)Background: Viral infections are among the most common problems in health-care practice. Natural products offer great promise as potentially effective antiviral drugs. Propolis is a honeybee product with biological properties ... -
Curcumin- and Piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of Curcumin on HCT116 colorectal cancer model
Bolat, Zeynep Büşra; İşlek, Zeynep; Demir, Bilun Nas; Yılmaz, Elif Nur; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Frontiers in Bioengineering and Biotechnology, 2020)Combination chemotherapy, administrating two chemotherapeutic agents concurrently, comes into prominence, as the heterogeneity or the level of the disease necessitates a collaborative action. Curcumin, isolated from turmeric, ... -
Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell
Bolat, Zeynep Büşra; İşlek, Zeynep; Şahin, Fikrettin; Üçışık, Mehmet Hikmet (Springer, 2023)Background: Curcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various cancer types including prostate cancer. However, low water solubility ... -
Effect of a novel bioceramic root canal sealer on the angiogenesis-enhancing potential of assorted human odontogenic stem cells compared with principal tricalcium silicate-based cements
Olcay, Keziban; Taşlı, Pakize Neslihan; Pamukçu Güven, Esra; Yalçın Ülker, Gül Merve; Esen Öğüt, Emine; Çiftçioǧlu, Elif; Kıratlı, Binnur; Şahin, Fikrettin (Bauru School of Dentistry, University of Sao Paulo, 2020)Objective: This study evaluated the angiogenesis-enhancing potential of a tricalcium silicate-based mineral trioxide aggregate (ProRoot MTA), Biodentine, and a novel bioceramic root canal sealer (Well-Root ST) in human ... -
Effect of schiff base combination on liver cancer
Doğan, Ayşegül; Başak, Nandini Pal; Telci, Dilek; Dede, Bülent; Kılıç, Ertuğrul; Kılıç, Kübra; Şahin, Fikrettin (Wiley-Blackwell, 2013)… -
Enhancement of cisplatin sensitivity in human cervical cancer: Epigallocatechin-3-gallate
Kılıç, Ülkan; Şahin, Kazım; Tuzcu, Mehmet; Başak, Nazlı; Orhan, Cemal; Elibol Can, Birsen; Kılıç, Ertuğrul; Şahin, Fikrettin; Küçük, Ömer (Frontiers Media, 2015)Cisplatin is one of the effective chemotherapeutics in the treatment of several types of cancers. However, in addition to the efforts against to its toxicity, the amelioration of cisplatin sensitivity is an important point ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
HMG-CoA reductase inhibitor rosuvastatin improves abnormal brain electrical activity via mechanisms involving eNOS
Şeker, Fatma Burcu; Kılıç, Ülkan; Çaǧlayan, Berrak; Ethemoğlu, Muhsine Sinem; Çağlayan, Ahmet Burak; Ekimci, Nur; Demirci, Selami; Doǧan, Ayşegül; Öztezcan, Serdar; Şahin, Fikrettin; Yılmaz, Bayram; Kılıç, Ertuğrul (Elsevier, 2015)Apart from its repressing effect on plasma lipid levels, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors exert neuroprotective functions in animal models of neurodegenerative disorders. In view of ... -
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
Kılıç, Ülkan; Kılıç, Ertuğrul; Tuzcu, Zeynep; Tuzcu, Mehmet; Özercan, İbrahim; Yılmaz, Ökkeş; Şahin, Fikrettin; Şahin, Kazım (Biomed Central Ltd, 2013)Background: Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited ... -
Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
Karakaş, Nihal; Bay, Sadık; Türkel, Nezaket; Öztunç, Nurşah; Öncül, Merve; Bilgen, Hülya; Shah, Khalid; Şahin, Fikrettin; Öztürk, Gürkan (Public Library of Science, 2020)Mesenchymal stem cells have the ability to transdifferentiate into neurons and therefore one of the potential adult stem cell source for neuronal tissue regeneration applications and understanding neurodevelopmental ... -
Poloxamer P85 increases anticancer activity of schiff base against prostate cancer in vitro and in vivo
Demirci, Selami; Doğan, Ayşegül; Türkmen Bacak, Neşe; Telci, Dilek; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ertuğrul; Özkan, Ferda; Dede, Bülent; Şahin, Fikrettin (Lippincott Williams and Wilkins, 2017)Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective ... -
The role of a single nucleotide polymorphism of the matrix metalloproteinase-1 gene promoter region in invasion and prognosis of meningiomas
Efendioğlu, Mustafa; Başaran, Recep; Bayrak, Ömer Faruk; Işık, Nejat; Kaner, Tuncay; Şahin, Fikrettin; Güçlü, Bülent; Elmacı, İlhan (Turkish Neurosurgical Society, 2014)AIM:The matrix metalloproteinase (MMP) enzyme family has been shown to be active in tumorigenesis and tumor progression. In this study, we analyzed the prevalence of a guanine insertion in the MMP-1 gene promoter region ... -
Schiff base-poloxamer p85 combination prevents prostate cancer progression in c57/bl6 mice
Doǧan, Ayşegül; Demirci, Selami; Başak Türkmen, Neşe; Çağlayan, Ahmet Burak; Aydın, Safa; Telci, Dilek; Kılıç, Ertuğrul; Şahin, Kazım; Orhan, Cemal; Tuzcu, Mehmet; Doğan Ekici, Asiye Işın; Şahin, Fikrettin (Wiley, 2016)BACKGROUNDProstate cancer which is the second most common cause of death among men has a high incidence in recent years. Current therapeutic regimens should be improved to overcome drug resistance. At the metastatic stage, ... -
Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo
Doǧan, Ayşegül; Demirci, Selami; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Günal, Mehmet Yalçın; Uslu, Ünal; Cumbul, Alev; Şahin, Fikrettin (Humana Press, 2014)After a disruption of skin integrity, the body produces an immediate response followed by a functional and comparable regeneration period, referred to as wound healing. Although normal wounds do not need much attention ...
