Browsing by Author "Ünal, İsmail"
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3-Pyridinylboronic acid ameliorates rotenone-induced oxidative stress through Nrf2 target genes in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Üstündağ, Ünsal Veli; Cansız, Derya; Beler, Merih; Karagöz, Atakan; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Springer, 2022)Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is ... -
3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos
Üstündağ, Fümet Duygu; Ünal, İsmail; Cansız, Derya; Üstündağ, Ünsal Veli; Kara Subaşat, Hülya; Alturfan, Ahmet Ata; Mega Tiber, Pınar; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of ... -
Amelioration of rotenone-induced alterations in energy/redox system, stress response and cytoskeleton proteins by octanoic acid in zebrafish: A proteomic study
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Büyükkayhan, Derya; Emekli Alturfan, Ebru (Wiley, 2022)Rotenone is used to generate Parkinson's disease (PD)-like symptoms in experimental animals. Octanoic acid (C8), is the principal fatty acid of medium-chain triglycerides in ketogenic diets. Beneficial effects of ketogenic ... -
The biocompatibility of sodium lauryl sulphate on developing zebrafish embryos
Meşeli, Simge; Kaplan, Gül; Cansız, Derya; Üstündağ, Ünsal Veli; Ünal, İsmail; Emekli Alturfan, Ebru; Yanıkoğlu, Funda; Tağtekin, Dilek (AVES, 2021)Objective: As an anionic surfactant, sodium lauryl sulphate (SLS), is used as an emulsifying agent in toothpastes as well as many different household cleaning products. Many toothpastes contain SLS and it is responsible ... -
Bisphenol a and di(2-ethylhexyl) phthalate exert divergent effects on apoptosis and the Wnt/-catenin pathway in zebrafish embryos: A possible mechanism of endocrine disrupting chemical action
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Sage Publications Inc, 2017)Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to ... -
Bisphenol a reveals its obesogenic effects through disrupting glucose tolerance, oxidant–antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish
Beler, Merih; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Dandin, Esra; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (SAGE Publications Ltd, 2022)Obesogens affect lipid metabolism, and genetic or epigenetic factors may also contribute to the progression of obesity. Endocrine-disrupting chemicals (EDCs) are the most striking among obesogens. Bisphenol A (BPA) is an ... -
Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish
Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Altınöz, Meriç A.; Elmacı, İlhan; Emekli Alturfan, Ebru (Springer, 2021)Background Dysfunction of the gastrointestinal tract (GIT) is one of the most common non-motor symptom of Parkinson's Disease (PD). Pathological processes causing PD were suggested to initiate in the enteric nervous system ... -
The effect of different storage conditions on the migration of chemicals from polyethylene terephthalate and polycarbonate bottles to water
Seyhan, Gümrah; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Emekli Alturfan, Ebru; Alturfan, Ahmet Ata (Istanbul University, 2022)Objective: Polyethylene terephthalate (PET) and polycarbonate (PC) bottles have been used widely in the last years for the consumption of water and the increased use of these chemicals has raised many concerns regarding ... -
Effects of water samples in polyethylene terephthalate bottles stored at different conditions on zebrafish embryos with relevance to endocrine disrupting chemical migration and adenomatous polyposis coli tumor suppressor gene
Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Tırpanç, Aybüke; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli-Alturfan, Ebru (Marmara University, 2019)Objective: Polyethylene terephthalate (PET) is a material that is most commonly used for production of clear plastic bottles. Adenomatous polyposis coli (APC) and beta-catenin have been related with cancer. Aim was to ... -
Evaluation of the interaction between proliferation, oxidant-antioxidant status, Wnt pathway, and apoptosis in zebrafish embryos exposed to silver nanoparticles used in textile industry
Eryılmaz, Oğuz; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Bay, Sadık; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru; Akalın, Mehmet (Wiley, 2018)Antimicrobial textile products are developing rapidly as an important part of functional textiles. Silver nanoparticles (AgNPs) are nanotechnology products with antimicrobial properties. However, exposure to nanoparticles ... -
Methylnitrosourea, dimethylbenzanthracene and benzoapyrene differentially affect redox pathways, apoptosis and immunity in zebrafish
Eğimezer, G.; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, F. D.; Alturfan, Ahmet Ata; Emekli-Alturfan, Ebru; Adil Altınöz, Meriç; Elmacı, İlhan (SAGE Publications Ltd, 2020)Cancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between ... -
Methylparaben induces malformations and alterations on apoptosis, oxidant-antioxidant status, ccnd1 and myca expressions in zebrafish embryos
Ateş, Perihan Seda; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Wiley, 2018)Methylparabens (MP) are widely used as preservatives in cosmetics, pharmacy, and food industry. Although acute toxicity studies in animals indicated that parabens are not significantly toxic, the effects of chronic exposure ... -
Morphine attenuates neurotoxic effects of MPTP in zebrafish embryos by regulating oxidant/antioxidant balance and acetylcholinesterase activity
Cansız, Derya; Üstündağ, Ünsal Veli; Ünal, İsmail; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Parkinson's disease (PD) is one of the most common neurodegenerative diseases due to the loss of dopaminergic neurons in the midbrain in the substantia nigra. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a ... -
Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
Ünal, İsmail; Çalışkan-Ak, Esin; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Altınöz, Meriç Adil; Elmacı, İlhan; Emekli-Alturfan, Ebru (Taylor and Francis Ltd, 2020)Aim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson’s disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone ... -
Oxidative stress and apoptosis in electromagnetic waves exposed Zebrafish embryos and protective effects of conductive nonwoven fabric
Üstündağ, Ünsal Veli; Özen, Mustafa Sabri; Ünal, İsmail; Ateş, Perihan Seda; Alturfan, Ahmet Ata; Akalın, Mehmet; Sancak, Erhan; Emekli Alturfan, Ebru (CMB Association, 2020)The amount of technological products including television, radio transmitters, and mobile phone that have entered our daily life has increased in recent years. But these devices may cause adverse effects on human health. ... -
Quantitative phosphoproteomics to resolve the cellular responses to octanoic acid in rotenone exposed zebrafish
Sürmen, Mustafa Gani; Sürmen, Saime; Cansız, Derya; Ünal, İsmail; Üstündağ, Ünsal Veli; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2021)Ketosis is a potentially beneficial metabolic state for health especially in neurological conditions including Parkinson's disease (PD). Medium-chain-triglycerides (MCT) have specific metabolic properties and they are ... -
Rifampicin decreases neuroinflammation to maintain mitochondrial function and calcium homeostasis in rotenone-treated zebrafish
Yurtsever, İlknur; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş, Perihan Seda; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2022)Among the mechanisms underlying Parkinson’s disease, many pathogenic mechanisms are suggested to be effective such as oxidative stress, mitochondrial dysfunction, disruption of the ubiquitin-proteasome system, and ... -
Rotenone impairs oxidant/antioxidant balance both in brain and intestines in zebrafish
Ünal, İsmail; Üstündağ, Ünsal Veli; Ateş, Perihan Seda; Eğilmezer, Gizem; Alturfan, Ahmet Ata; Yiğitbaşı, Türkan; Emekli Alturfan, Ebru (Taylor & Francis Ltd, 2019)Aim of the study: Rotenone is a commonly used pesticide that inhibits complex I of the mitochondrial electron transport system. Rotenone exposed rats demonstrate many characteristics of Parkinson Disease (PD). Oxidative ... -
Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation
Dandin, Esra; Üstündağ, Ünsal Veli; Ünal, İsmail; Ateş Kalkan, Perihan Seda; Cansız, Derya; Beler, Merih; Ak, Esin; Alturfan, A. Ata; Emekli Alturfan, Ebru (Elsevier Ltd, 2022)Obesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have ... -
White LED light exposure inhibits the development and xanthophore pigmentation of zebrafish embryo
Üstündağ, Ünsal Veli; Çalışkan-Ak, Esin; Ateş, Perihan Seda; Ünal, İsmail; Eğilmezer, Gizem; Yiğitbaşı, Türkan; Alturfan, Ahmet Ata; Emekli-Alturfan, Ebru (Nature Publishing Group, 2019)Circadian rhythm in all living organisms is disturbed continuously by artificial light sources and artificial lighting has become a hazard for public health. Circadian rhythm of melatonin maintains high levels of melatonin ...
