Yazar "Özşimşek, Ahmet" için listeleme
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Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: A randomised, double-blinded, placebo-controlled phase-II trial
Yuluğ, Burak; Altay, Özlem; Li, Xiangyu; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Yang, Hong; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Hacimuftüoğlu, Ahmet; Yıldırım, Serkan; Arif, Muhammad; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Türkez, Hasan; Borén, Jan; Uhlén, Mathias; Mardinoglu, Adil (BioMed Central Ltd, 2023)Background: Alzheimer’s disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined metabolic activators (CMA) to the AD rat model and observed ... -
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
Türkez, Hasan; Altay, Özlem; Yıldırım, Serkan; Li, Xiangyu; Yang, Hong; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Arif, Muhammad; Yuluğ, Burak; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Hacımüftüoğlu, Ahmet; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Borén, Jan; Uhlén, Mathias; Mardinoğlu, Adil (Elsevier Inc., 2023)Background: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies ... -
EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line
Övey, İshak Suat; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Altay, Özlem; Mardinoğlu, Adil; Yuluğ, Burak (Frontiers Media SA, 2023)Background: Transient receptor potential (TRP) channels have been found to have significant implications in neuronal outgrowth, survival, inflammatory neurogenic pain, and various epileptogenic processes. Moreover, there ... -
The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder
Yuluğ, Burak; Ayyıldız, Sevilay; Sayman, Dila; Karaca, Ramazan; İpek, Lütfiye; Çankaya, Şeyda; Salar, Ali Behram; Ayyıldız, Behçet; Mikuta, Christian; Yağcı, Nilay; Özdemir Öktem, Ece; Özşimşek, Ahmet; Velioğlu, Halil Aziz; Hanoğlu, Lütfü (John Wiley and Sons Inc, 2024)INTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their ... -
Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
Yuluğ, Burak; Ayyıldız, Behçet; Ayyıldız, Sevilay; Sayman, Dila; Salar, Ali Behram; Çankaya, Şeyda; Özdemir, Ece; Özşimşek, Ahmet; Kurt, Çağla Ceren; Lakadamyalı, Hatice; Aktürk, Aynur; Altay, Özlem; Hanoğlu, Lütfü; Velioğlu, Halil Aziz; Mardinoğlu, Adil (John Wiley and Sons Inc, 2023)Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that ... -
Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
Çankaya, Şeyda; Özdemir Öktem, Ece; Saatçi, Özlem; Velioğlu, Halil Aziz; Uygur, Abdullah Burak; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Retraction notice to "Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases" [Life Sci. 314 (2023) 121325]
Türkez, Hasan; Altay, Özlem; Yıldırım, Serkan; Li, Xiangyu; Yang, Hong; Bayram, Cemil; Bolat, İsmail; Öner, Sena; Özdemir Tozlu, Özlem; Arslan, Mehmet Enes; Arif, Muhammad; Yuluğ, Burak; Hanoğlu, Lütfü; Çankaya, Şeyda; Lam, Simon; Velioğlu, Halil Aziz; Coşkun, Ebru; İdil, Ezgi; Nogaylar, Rahim; Özşimşek, Ahmet; Hacımüftüoğlu, Ahmet; Shoaie, Saeed; Zhang, Cheng; Nielsen, Jens; Borén, Jan; Uhlén, Mathias; Mardinoğlu, Adil (2024)This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of Editor-in-Chief. The journal was alerted ... -
Smoking affects global and regional brain entropy in depression patients regardless of depression: preliminary findings
Velioğlu, Halil Aziz; Yıldız, Sultan; Özdemir Öktem, Ece; Çankaya, Şeyda; Lundmark, Anton Kjell; Özşimşek, Ahmet; Hanoğlu, Lütfü; Yuluğ, Burak (2024)Objective: This study examines the effect of smoking on global and regional brain entropy in patients with Major Depressive Disorder (MDD), aiming to elucidate the relationship between smoking habits and brain network ... -
Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
Uykur, Abdullah Burak; Yıldız, Sultan; Velioğlu, Halil Aziz; Özşimşek, Ahmet; Özdemir Öktem, Ece; Bayraktaroğlu, Zübeyir; Ergün, Tarkan; Lakadamyalı, Hatice; Hanoğlu, Lütfü; Çankaya, Şeyda; Saatçi, Özlem; Yuluğ, Burak (Elsevier Ltd, 2021)Aim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on ...