Browsing by Author "Çubukçu, Erdem"
Now showing items 1-13 of 13
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Anti-Ri-associated paraneoplastic neurological syndrome: Initial symptom of breast cancer with HER2 overexpression and treatment by dual HER2 blockade
Ölmez, Ömer Fatih; Kınıkoğlu, Oğuzcan; Helvacı Yılmaz, Nesrin; Bilici, Ahmet Erkan; Çubukçu, Erdem; Şeker, Mesut Metin; Çakır, Tansel; Yıldız, Özcan; Hamdard, Jamshid (SAGE Publications Ltd, 2019)Paraneoplastic neurological syndrome is associated with anti-Ri antibodies, which are typically present with opsoclonus–myoclonus–ataxia. Human epidermal growth factor receptor 2 (HER2) overexpression is present in 15%–25% ... -
Are pretreatment inflammation-based prognostic scores useful in predicting the outcomes of patients with ALK-positive NSCLC?
Ölmez, Ömer Fatih; Bilici, Ahmet; Gürsoy, Pınar; Çubukçu, Erdem; Yıldız, Özcan; Sakın, Abdullah; Korkmaz, Taner; Çil, İbrahim; Çakar, Beyhan; Menekşe, Serkan; Demir, Tarık; Açıkgöz, Özgen; Hamdard, Jamshid (Elsevier Science, 2019)Background: Approximately 5% of all diagnosed non-small cell lung cancer (NSCLC) patients harbor a genetic rearrangement between the ALK and EML4 genes, representing a specific molecular and clinical subgroup (ALK+ NSCLC). ... -
Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer
Avcı, Nilüfer; Türe, Mehmet; Deligönül, Adem; Çubukçu, Erdem; Ölmez, Ömer Fatih; Şahintürk, Serdar; Topak, Ali; Kurt, Ender; Evrensel, Türkan; Şahin, Ahmet Bilgehan; Yakut, Tahsin (Springer, 2015)Matrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case-control ... -
Crizotinib efficacy in alk-positive advanced stage non-small cell lung cancer patients: A real-world experience from Turkey
Kılıçkap, Sadettin; Öztürk, Akın; Karadurmuş, Nuri; Korkmaz, Taner; Yumuk, Perran Fulden; Çiçin, İrfan; Paydaş, Semra; Çılbır, Ebru; Sakalar, Teoman; Uysal, Mükremin; Üskent, Necdet; Demir, Nurcan; Sakin, Ayşegül; Turhal, Nazım Serdar; Keskin, Serhat; Tural, Deniz; Eralp, Yeşim; Buğdaycı Başal, Fatma; Yaşar, Hatime Arzu; Sendur, Mehmet Ali Nahit; Demirci, Umut; Çubukçu, Erdem; Karaağaç, Mustafa; Karaca, Saziye; Tatlı, Ali Murat; Yetişyiğit, Tarkan; Urvay, Semiha; Gürsoy, Pınar; Oyan Uluç, Başak; Turna, Zeynep Hande; Küçüköner, Mehmet; Ölmez, Ömer Fatih; Çabuk, Devrim; Şeker, Mesut; Ünal, Olçun Umut; Meydan, Nezih; Okutur, Sadi Kerem; Tunalı, Duygu (Elsevier Science Inc, 2018)Background: Increasing evidence leads to a ratiocination that genetic heterogeneity of the lung adenocarcinoma patients with sensitive EGFR mutations may impact clinical responses and outcomes to EGFR-TKIs. Method: We ... -
Is there any prognostic significance in pleural involvement and/or effusion (Ple-I/E) in patients with ALK-positive NSCLC?
Kılıçkap, Saadettin; Buğdaycı Basal, Fatma; Demirkazık, Ahmet; Gürsoy, Pınar; Demirci, Ufuk; Erman, Mustafa; Yumuk, Fulden; Çay Şenler, Filiz; Çakar, Burcu; Çiçin, İrfan; Öztürk, Akın; Coşkun, Hasan Şenol; Çubukçu, Erdem; Işıkdoğan, Abdurrahman; Ölmez, Ömer Fatih; Tatlı, Ali Murat; Karaağaç, Mehmet Onur; Sakalar, Teoman; Eralp, Yeşim; Korkmaz, Taner (Oxford University Press, 2019)Background: ALK mutation occurs in approximately 3-5% of patients with NSCLC. At the baseline, Ple-I/E are more frequent in ALKþ patients with NSCLC. In the study, we aimed to evaluate characteristics of ALKþpatients who ... -
Medication errors in chemotherapy preparation and administration: A survey conducted among oncology nurses in Turkey
Ulaş, Arife; Sılay, Kamile; Akıncı, Sema; Dede, Didem Şener; Akıncı, Muhammed Bülent; Şendur, Mehmet Ali; Çubukçu, Erdem; Çoşkun, Hasan Şenol; Deǧirmenci, Mustafa; Utkan, Güngör Ör; Özdemir, Nuriye Yıldırım; Işıkdoğan, Abdurrahman; Büyükçeli̇k, Abdullah; İnanç, Mevlüde; Bilici, Ahmet Erkan; Odabaşı, Hatice; Cihan, Şener; Avcı, Nilüfer; Yalçın, Bülent (Asian Pacific Organization for Cancer Prevention, 2015)Background: Medication errors in oncology may cause severe clinical problems due to low therapeutic indices and high toxicity of chemotherapeutic agents. We aimed to investigate unintentional medication errors and underlying ... -
Metastatik meme kanseri tedavisinde lapatinib kapesitabin kombinasyonun etkinliğinin retrospektif değerlendirilmesi
Tüm dünyada meme kanseri kadınlarda kanserin ve kanser ilişkili ölümlerin en sık nedenidir. Meme kanserli hastaların %17-30 HER2overekspresyonu olup hastalık, kötü prognoz, hastalık progresyon riskinde artış, genel sağkalım ... -
Prognostic impact of tumor lymphocytic infiltrates in patients with breast cancer undergoing neoadjuvant chemotherapy
Avcı, Nilüfer; Deligönül, Adem; Tolunay, Sahsine; Çubukçu, Erdem; Ölmez, Ömer Fatih; Altmışdörtoğlu, Özgür; Tanrıverdi, Özgür; Aksoy, Asude; Kurt, Ender; Evrensel, Türkkan (Zerbinis Publications, 2015)Purpose: The presence of a pronounced tumor lymphocytic infiltrate (TLI) is deemed to reflect the presence of an immunoinflammatory response against the tumor and may thus have prognostic significance. We investigated the ... -
Real-life analysis of pathologic complete response with neoadjuvant trastuzumab plus taxane with or without pertuzumab therapy in HER2 positive locally-advanced breast cancer (HER2PATH Study)
Bilici, Ahmet; Ölmez, Ömer Fatih; Sezer, Ahmet; Öksüzoğlu, Berna; Kaplan, Muhammet Ali; Karadurmuş, Nuri; Çubukçu, Erdem; Şendur, Mehmet Ali Nahit; Aksoy, Sercan; Erdem, Dilek; Başaran, Gül; Çakar, Burcu; Şeker, Mesut; Arslan, Çağatay; Sezgin Göksu, Sema; Çiçin, İrfan; Gümüş, Mahmut; Selçukbiricik, Fatih; Harputluoğlu, Hakan; Helvacı, Kaan (Lippincott Williams and Wilkins, 2022)... -
Real-life experience with maintenance chemotherapy plus biologics after the first-line treatment of RAS wild-type metastatic colon cancer (mCRC): A multicenter Onco-Colon Turkey study
Artaç, Mehmet; Çubukçu, Erdem; Bozkurt, Oktay; Bilici, Ahmet; Çelik, S.; Özçelik, M.; Öven, B.; Şimşek, E.; Geredeli, C.; Karaca, M.; Cil, T.; Harputluoğlu, Hakan; Şendur, Mehmet Ali Nahit; Türk, H. Mehmet; Kefeli, Umut; Alacacıoğlu, Ahmet; Tural, D.; Sakin, A.; Karadurmuş, Nuri; Çevik, Duygu; Dane, Faysal; Gümüş, Mahmut (Elsevier, 2022)Background: Randomized clinical trials showed that maintenance chemotherapy plus biologics in patients with mCRC could increase the progression free survival (PFS) without any advantage for overall survival (OS). Our aim ... -
Real-world treatment outcomes from nationwide ONCO-colon Turkey registry in RAS wild-type patients treated with biologics first-line metastatic colorectal cancer
Kefeli, Umut; Arslan, Çağatay; Yıldırım, Mahmut Emre; Işıkdoğan, Abdurrahman; Karadurmuş, Nuri; Karabulut, Bülent; Çubukçu, Erdem; Çiçin, İrfan; Yalçın, Şuayib; Türk, Hacı Mehmet; Bilir, Cemil; Karaca, Mustafa; Artaç, Mehmet; Şendur, Mehmet Nahit; Alacacıoğlu, Ahmet; Tanrıkulu Şimşek, Eda; Dane, Faysal; Bilici, Ahmet; Çevik, Duygu; Gümüş, Mahmut (Lippincott Williams & Wilkins, 2021)Background: Efficacy of anti-angiogenic and anti-EGFR agents has been demonstrated metastatic colorectal cancer (mCRC). Real-world evidence is especially important to detect the findings of patients outside of clinical ... -
Surgical, pathological and clinical features of advanced collorectal cancers with metastasectomy. "Onco-Colon Turkey Registry" real-life data
Karadurmuş, Nuri; Yıldırım, Emre; Yalçın, Şuayib; Gümüş, Mahmut; Bilir, Cemil; Çubukçu, Erdem; Tanrıkulu Şimşek, Eda; Arslan, Çağatay; Dane, Faysal; Çelik, Sinemiş; Bilici, Ahmet; Şendur, Mehmet Ali Nahit; Öven, Başak Bala; Işıkdoğan, Abdurrahman; Türk, Hacı Mehmet; Karaca, Mustafa; Karabulut, Bülent; Özçelik, Melike; Çevik, Duygu; Kefeli, Umut (Lippincott Williams & Wilkins, 2022)Background: The contribution of metastasectomy to progression-free survival (PFS) and overall survival (OS) in patients (pts) with advanced stage colorectal cancer has been demonstrated in clinical trials. However, clinical ... -
Systemic inflammatory markers as a predictors of response to crizotinib in patients with ALK-positive non-small-cell lung cancer
Bilici, Ahmet; Ölmez, Ömer Fatih; Gürsoy, Pınar; Çubukçu, Erdem; Yıldız, Özcan; Sakın, Abdullah; Korkmaz, Taner; Çil, İbrahim; Çakar, Beyhan; Menekşe, Serkan; Demir, Tarık; Açıkgöz, Özgen; Hamdard, Jamshid (Elsevier Science Inc, 2019)The significance of the presence of a systemic inflammatory response (SIR) in predicting survival has been demonstrated in patients with cancer. Moreover, neutrophil-to-lymphocyte ratio (NLR), lymphocyteratio (NLR), ...
