Browsing by Author "Çakır, Aslı"
Now showing items 1-20 of 72
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Abortifacient effect of decreased decidual and placental galectin-1 expression due to metoclopramide exposure in pregnant rats
Çekmez, Yasemin; Korkmaz, Vakkaş; Çakır, Aslı; Göçmen, Ahmet; Ergün, Yusuf; Gülşen, Serdar (Journal of Reproductive Medicine, Inc., 2017)OBJECTIVE: To investigate the abortifacient effect of metoclopramide on decidual and trophoblastic tissues with immunohistochemical investigation of galectin-1 expression in pregnant rats. STUDY DESIGN: A total of 24 ... -
Acute temozolomide induced liver injury: Mixed type hepatocellular and cholestatic toxicity
Aygün, Cem; Yıldırım Altınok, Ayşe; Çakır, Aslı; Ağan, Ahmet Faruk; Balaban, Yasemin (Universa Press, 2016)Temozolomide (TMZ) is an oral imidazotetrazine methylating agent which is used for the treatment of glioblastoma multiforme (GBM). We report a case of acute hepatotoxicity in a 53-year old male patient after administration ... -
Acute temozolomide induced liver injury: Mixed type hepatocellular and cholestatic toxicity
Aygün, Cem; Yıldırım Altınok, Ayşe; Çakır, Aslı; Ağan, Ahmet Faruk; Balaban, Yasemin (Universa Press, 2016)Temozolomide (TMZ) is an oral imidazotetrazine methylating agent which is used for the treatment of glioblastoma multiforme (GBM). We report a case of acute hepatotoxicity in a 53-year old male patient after administration ... -
Adult case series of extramedullary relapsing acute myeloid leukemia (AML) after allogeneic stem cell transplantation in whom a rapid response and a reasonably long remission could be achieved with gemtuzumab ozogamycin (GO)
Sevindik, Ömür Gökmen; Gemici, Aliihsan; Usta, Furkan Selim; Çakır, Aslı; Sadri, Sevil; Bekoz, Hüseyin; Sargın, Fatma Deniz (The American Society of Hematology, 2019)Gemtuzumab Ozogamycin (GO) is a drug conjugated monoclonal antibody which targets CD33 an antigen highly expressed on the surface of AML blasts. GO is approved for the treatment of both newly-diagnosed and relapsed AML. ... -
Artificial intelligence assistance significantly improves Gleason grading of prostate biopsies by pathologists
Bulten, Wouter; Balkenhol, Maschenka; Belinga, Jean-Joel Awoumou; Brilhante, Americo; Çakır, Aslı; Egevad, Lars; Eklund, Martin; Farre, Xavier; Geronatsiou, Katerina; Molinie, Vincent; Pereira, Guilherme; Roy, Paromita; Saile, Gunter; Salles, Paulo; Schaafsma, Ewout; Tschui, Joelle; Vos, Anne-Marie; van Boven, Hester; Vink, Robert; van der Laak, Jeroen; Hulsbergen-van der Kaa, Christina; Litjens, Geert (Springer Nature, 2021)The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability. Artificial intelligence (AI) systems based on deep learning can achieve ... -
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: The PANDA challenge
Bulten, Wouter; Kartasalo, Kimmo; Chen, Po-Hsuan Cameron; Ström, Peter; Pinckaers, Hans; Nagpal, Kunal; Cai, Yuannan; Steiner, David F.; van Boven, Hester; Vink, Robert; Hulsbergen-van de Kaa, Christina; van der Laak, Jeroen; Amin, Mahul B.; Evans, Andrew J.; van der Kwast, Theodorus; Allan, Robert; Humphrey, Peter A.; Grönberg, Henrik; Samaratunga, Hemamali; Delahunt, Brett; Tsuzuki, Toyonori; Häkkinen, Tomi; Egevad, Lars; Demkin, Maggie; Dane, Sohier; Tan, Fraser; Valkonen, Masi; Corrado, Greg S.; Peng, Lily; Mermel, Craig H.; Ruusuvuori, Pekka; Litjens, Geert; Eklund, Martin; Brilhante, Américo; Çakır, Aslı; Farré, Xavier; Geronatsiou, Katerina; Molinié, Vincent; Pereira, Guilherme; Roy, Paromita; Saile, Günter; Salles, Paulo G. O.; Schaafsma, Ewout; Tschui, Joëlle; Billoch-Lima, Jorge; Pereira, Emíio M.; Zhou, Ming; He, Shujun; Song, Sejun; Sun, Qing; Yoshihara, Hiroshi; Yamaguchi, Taiki; Ono, Kosaku; Shen, Tao; Ji, Jianyi; Roussel, Arnaud; Zhou, Kairong; Chai, Tianrui; Weng, Nina; Grechka, Dmitry (Nature Research, 2022)Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital ... -
Atypical fibroxanthoma arising on chronic burn scar: A rare case report and the review of the literature
Çalış, Elif; Keskin, Mustafa; Çakır, Aslı; Türkmen, İlknur (Springer, 2018)Atypical Fibroxanthoma (AFX) is a rare cutaneous mesenchymal neoplasm, predominantly found on sundamaged skin of the head and neck in elderly patients. But uncommonly it can develop on a burn scar with or without actinic ... -
Automated scoring of CerbB2/HER2 receptors using histogram based analysis of immunohistochemistry breast cancer tissue images
Kabakçı, Kaan Aykut; Çakır, Aslı; Türkmen, İlknur; Töreyin, Behçet Uğur; Çapar, Abdulkerim (Elsevier Ltd, 2021)Background and Objective: Visual expression of invasive breast cancer with immunohistochemistry (IHC) allows evaluation of CerbB2 receptors, such that CerbB2 mutated breast carcinomas are suitable for targeted therapy. ... -
Bilateral oropharyngeal hairy polyps: A rare cause of dyspnea in newborns
Yılmazer, Rasim; Kersin, Burak; Soylu, Erkan; Altın, Gökhan; Çakır, Aslı; Yılmaz, Fahrettin (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2017)Hairy polyp (HP) is one of the causes of congenital dyspnea, a rare developmental malformation of bigerminal origin that comprises both ectodermal and mesodermal elements foreign to the site in which it is found. It typically ... -
Can the use of reference pictures improve the interobserver variability on assessment of liver steatosis percentage: A digital platform based approach
Türkmen Çetinaslan, İlknur; Çakır, Aslı; Çapar, Aslı Gizem; Saka, Burcu; Kahraman, Zuhal; Erkan, Sengiz; Özkan, Yücel; Kepil, Nuray; Keser, Sevinç Hallaç; Güçin, Zuhal; Ceyran, Bahar; Çoban, Ganime; Yılmaz Seğmen, Müberra; Arıcı, Sema; Dursun, Nevra; Doğusoy, Gülen Bülbül; Tuncel, Dilek; Özgüven Yılmaz, Banu; Paşaoğlu, Esra; Kamalı Harman, Gülçin; Kırımlıoğlu, Hale; Erdamar, Sibel; Yıldız, Şemsi; Erdoğan Yıldırım, Nilsen; Armutlu, Ayşe (Springer, 2017)… -
Case report of a primary renal vein leiomyosarcoma
Yılmaz Erözbek, Sıla; Çakır, Aslı; Dervişoğlu, Sergülen (Springer, 2022)... -
Chordoid meningioma: Report of 5 cases and review of the literature
Tahta, Alican; Genç, Berkhan; Çakır, Aslı; Şekerci, Zeki (Taylor & Francis Ltd, 2023)Chordoid meningioma is a rare, more aggressive subtype of meningioma. This study documents the histological, radiological and clinical features of seven tumours in five patients among 131 meningioma patients who were treated ... -
Clinicopathological significance of insulin-like growth factor-1 receptor expression in breast cancer
Şahin, Sevinç; Çakır, Aslı; Gönül, İpek Işık; Seçkin, Selda; Uluoğlu, Ömer (Edizioni Luigi Pozzi, 2020)OBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) is a receptor protein tyrosine kinase that is claimed to be related with tumor development and progression of breast cancer with some conflicting results in the ... -
Clinicopathological significance of the proliferation markers Ki67, RacGAP1, and topoisomerase 2 alpha in breast cancer
Şahin, Sevinç; Işık Gönül, İpek; Çakır, Aslı; Seçkin, Selda; Uluoğlu, Ömer (Sage Publications Inc, 2016)Objectives. The aims of this study are to evaluate expressions of Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed to affect the prognosis in ... -
Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases
Batur, Şebnem; Dülger, Onur; Durak, Şermin; Yumuk, Perran Fulden; Çağlar, Hale Başak; Bozkurtlar, Emine; Bozkurt, Süheyla; Taştekin, Ebru; Çiçin, İrfan; Ahiskalı, Rengin; Çakır, Aslı; Öz, Büge (2020)Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially ... -
Discoid lupus erythematosus at the site of healed herpes zoster: Wolf's isotopic response: Case report
Balevi, Ali; Yüksel, Mavişe; Tavlı,Yeliz; Çakır, Aslı; Özdemir, Mustafa (Turkiye Klinikleri, 2013)The term Wolf's isotopic response refers to the appearance of a new skin disease at the site of an already healed, unrelated disease. In most cases, the initial disease is herpes zoster. Different diseases may subsequently ...
