Browsing by Author "Çağlayan, Ahmet Burak"
Now showing items 1-20 of 57
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Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Carnosine protects against cerebral ischemic injury by inhibiting matrix-metalloproteinases
Kim, Eun-Hye; Kim, Eun-Sun; Shin, Donggeun; Kim, Donghyun; Choi, Sungbin; Shin, Young-Jun; Kim, Kyeong-A; Noh, Dabi; Çağlayan, Ahmet Burak; Rajanikant, G. K.; Majid, Arshad; Bae, Ok-Nam (MDPI, 2021)Stroke is one of the leading causes of death and disability worldwide. However, treatment options for ischemic stroke remain limited. Matrix-metalloproteinases (MMPs) contribute to brain damage during ischemic strokes by ... -
CDNF ve manf nörotrofik faktörlerinin iskemi sonrası beyin plastisitesi ve onarımı üzerine olan etkileri
Çağlayan, Ahmet Burak (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Küçük protein yapıları ile nörotrofik faktörler, nöronların gelişimi sırasındaki rollerinin yanı sıra beyinde nöronların hayatta kalımı, nörogenez ve sinaptik bağlantıların korunmasında da mutlak rol oynamaktadırlar. ... -
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
Effect of social isolation on the brain injury following focal cerebral ischemia in mice and proteomic approach for identifying possible cellular pathways
Çağlayan, Ahmet Burak; Daşdelen, Muhammed Furkan; Beker, Mustafa Çağlar; Özbay, Erkan; Kılıç, E. (Wiley, 2021)Social isolation has become a significant part of our everyday life during the Covid-19 pandemic, resulting in drastic effects on physiological wellbeing. It was shown that loneliness or psychosocial stress such as social ... -
Effects of neurotrophic factors cdnf and manf on brain plasticity and repair after brain ischemia
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Altunay, Serdar; Dalay, Arman; Dilden, Aysun; Sertel, Elif; Keleştemur, Taha; Yalçın, Esra; Kılıç, Ülkan; Saarma, Mart; Kılıç, Ertuğrul (Wiley-Blackwell, 2016)... -
Effects of normobaric oxygen and melatonin on reperfusion injury: Role of cerebral microcirculation
Beker, Mustafa; Çağlayan, Ahmet Burak; Keleştemur, Taha; Çaǧlayan, Berrak; Yalçın, Esra; Yuluǧ, Burak; Kılıç, Ülkan; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Impact Journals, 2015)In order to protect the brain before an irreversible injury occurs, penumbral oxygenation is the primary goal of current acute ischemic stroke treatment. However, hyperoxia treatment remains controversial due to the risk ... -
The effects of topical liposomal resveratrol on incisional and excisional wound healing process
Günal, Mehmet Yalçın; Ayla, Şule; Bedri, Nejda; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Aslan, İsmail; Özdemir, Ekrem Musa; Yeşilada, Erdem; Kılıç, Ülkan (Turkish Society of Dermatology and Venereology, 2019)Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival
Yalçın, Esra; Beker, Mustafa Çağlar; Türkseven, Şeyma; Çağlayan, Berrak; Gürel, Büşra; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Kalkan, Rabia; Baykal, Ahmet Tarık; Keleştemur, Taha; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2019)Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. ... -
Hamile farelerde serebral iskemi sonrası akut ve kronik dönemde hasar mekanizmalarının incelenmesi
Kaya, İlayda (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Hamilelik ve doğum sonrası dönemde, hormonal değişimleri içeren birçok fizyolojik olayın meydana geldiği bilinmektedir. Meydana gelen hormonal değişimler hamileliğin korunmasına ve plasentanın gelişimine katkı sağlamaktadır. ... -
HMG-CoA reductase inhibition promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia
Kılıç, Ertuğrul; Reitmeir, Raluca; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kelestemur, Taha; Ethemoğlu, Muhsine Sinem; Öztürk, Gürkan; Hermann, Dirk M. (Frontiers Research Foundation, 2014)3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and ...
