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Alterations of ceramide synthesis induce PD-L1 internalization and signaling to regulate tumor metastasis and immunotherapy response
Wofford, Wyatt; Kim, Jisun; Kim, Dosung; Janneh, Alhaji H.; Lee, Han Gyul; Atılgan, Cansu; Oleinik, Natalia; Kassir, Mohamed Faisal; Saatçi, Özge; Chakraborty, Paramita; Tokat, Ünal Metin; Gencer, Salih; Howley, Breege; Howe, Philip; Mehrotra, Shikhar; Şahin, Özgür; Öğretmen, Besim (2024)Programmed death ligand 1, PD-L1 (CD274), facilitates immune evasion and exerts pro-survival functions in cancer cells. Here, we report a mechanism whereby internalization of PD-L1 in response to alterations of bioactive ...