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Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Doeppner, Thorsten R.; Coman, Cristin; Burdusel, Daiana; Ancuta, Diana Larisa; Brockmeier, Ulf; Pirici, Daniel Nicolae; Kuang Yaoyun; Hermann, Dirk M.; Popa Wagner, Aurel (Impact Journals LLC, 2022)Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an ...