Yazar "Ozansoy, Mehmet" için listeleme
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Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions
Ceylan, Bahadır; Ozansoy, Mehmet; Kılıç, Ülkan; Yozgat, Yasemin; Ercan, Çilem; Yıldız, Pelin; Aslan, Turan (Taylor & Francis Ltd., 2018)Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity.Methods: Twenty-eight Wistar rats were divided ... -
Neonatal neurodegeneration in alzheimer's disease transgenic mouse model
Mazi, Aişe Rümeysa; Arzuman, Ayşegül Sümeyye; Gürel, Büşra; Şahin, Betül; Tüzüner, Mete Bora; Ozansoy, Mehmet; Baykal, Ahmet Tarık (IOS Press, 2018)Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the ... -
Role of erythropoietin and its receptor in the development of endometriosis in rats
Günal, Mehmet Yalçın; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Özdemir, Ekrem Musa; Aslan, İsmail; Eren, Zehra; Ersavaş, Cenk; Kılıç, Ertuğrul (Galenos Yayıncılık, 2019)Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ... -
Semiosis as individuation: Integration of multiple orders of magnitude
Karatay, Vefa; Denizhan, Yağmur; Ozansoy, Mehmet (Springer Netherlands, 2016)This paper proposes Gilbert Simondon’s ontogenetic theory of individuation as an overarching framework for multilevel semiosis. What renders this theory suitable for this role is the fact that it shares a significant part ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
Şahin, Zafer; Biltekin, Sevde Nur; Ozansoy, Mehmet; Hemiş, Bervis; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Wiley, 2022)Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ... -
Therapeutic role of rifampicin in Alzheimer's disease
Yuluğ, Burak; Hanoǧlu, Lütfü; Ozansoy, Mehmet; Işık, Doğan; Kılıç, Ülkan; Kılıç, Ertuğrul; Schabitz, Wolf Rüdiger (Wiley, 2018)Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its ... -
Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Ozansoy, Mehmet; Altıntaş, Mehmet Özgen; Ozansoy, Muzaffer Beyza; Günay, Necmeddin; Kılıç, Ertuğrul; Kılıç, Ülkan (Scientific and Technological Research Council of Turkey (TÜBİTAK), 2020)Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, ... -
Yenidoğan alzheimer transgenik fare modelinde farklı beyin bölgelerinde protein profil değişimlerinin incelenmesi
Mazi, Aişe Rümeysa (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Alzheimer Hastalığı (AH), belirgin hafıza kayıplı kortikal demansa sebep olan çeşitli moleküler patolojilerle tanımlanan progresif bir hastalıktır. Hastalığın tanısından onlarca yıl önce oluşmaya başlayan patolojinin ...