Yazar "Günal, Mehmet Yalçın" için listeleme
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In vitro effects of rabeprazole on human pylorus tone
Yaşar, Necdet Fatih; Polat, Erdal; Duman, Mustafa; Dağdelen, Meltem; Günal, Mehmet Yalçın; Uzun, Orhan; Akyüz, Cebrail; Peker, Kıvanç Derya; Yol, Sinan (The Korean Society of Neurogastroenterlogy and Motility, 2015)Background/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus ... -
In vivo wound-healing and in vitro antibacterial and antioxidant of Carduus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Turkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
In vivo wound-healing and in vitro antibacterial and antioxidant properties of Carduus adpressus extract
Şakul, Ayşe Arzu; Ayla, Şule; Okur, Mehmet Evren; Karadağ, Ayşe Esra; Daylan, Benay; Güzel, Elif; Özdemir, Ekrem Musa; Günal, Mehmet Yalçın (Marmara University, 2023)Carduus adpressus has been used for its anti-hair loss effect in traditional folk medicine. The plant species is mainly distributed in Türkiye, Bulgaria, and the Western Caucasus. The studies on this specific plant in the ... -
Investigation of the effect of adalimumab on experimental brain injury in mice
Günal, Mehmet Yalçın; Çankaya, Seyda; Tönük, Şükrü Burak; Özdemir, Ekrem Musa; Sayın Şakul, Ayşe Arzu (2019)Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: ... -
Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
Okur, Mehmet Evren; Ayla, Şule; Polat, Derya Çiçek; Günal, Mehmet Yalçın; Yoltaş, Ayşegül; Biçeroğlu, Özge (Wiley, 2018)ObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Günal, Mehmet Yalçın; Çağlayan, Berrak; Yalçın, Esra; Keleştemur, Taha; Gündoğdu, Reyhan Zeynep; Yuluğ, Burak; Yılmaz, Bayram; Kerman, Bilal Ersen; Kılıç, Ertuğrul (Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model
Eren, Zehra; Günal, Mehmet Yalçın; Arı, Elif; Çoban, Jale; Çakalağaoğlu, Fulya; Çağlayan, Burak; Beker, Mustafa Çağlar; Akdeniz, Tuba; Yanıkkaya, Gülderen; Kılıç, Ertuğrul; Kantarcı, Gülçin (Karger, 2016)Background: This study aimed at investigating the possible protective effect of erythropoietin beta on experimental diabetic nephropathy (DN) model in rats. Methods: Sprague Dawley rats (n = 32) were allocated into 4 equal ... -
Protective effect of lutein/zeaxanthin isomers in traumatic brain injury in mice
Günal, Mehmet Yalçın; Şakul, Ayşe Arzu; Çağlayan, Ahmet Burak; Erten, Füsun; Durmaz Kurşun, Öznur Ece; Kılıç, Ertuğrul; Şahin, Kazım (Springer, 2021)Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert ... -
Prunus spinosa L. meyvelerinin deneysel yara iyileşmesi üzerine etkileri
Ayla, Şule; Günal, Mehmet Yalçın; Sayın Şakul, Ayşe Arzu; Biçeroğlu, Özge; Özdemir, Ekrem Musa; Okur, Mehmet Evren; Polat, Derya Çiçek; Üstündağ Okur, Neslihan; Bilgiç, Bülent Emre (2017)Farelerde oluşturduğumuz deneysel yara modellerinde, Prunus Spinosa L. metanollü meyve ekstresini kullanarak, bu ekstrenin yara iyileşmesindeki etkisini araştırdık. Otuz iki adet C57/Black fare ile 4 deney grubu oluşturuldu. ... -
Role of erythropoietin and its receptor in the development of endometriosis in rats
Günal, Mehmet Yalçın; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Özdemir, Ekrem Musa; Aslan, İsmail; Eren, Zehra; Ersavaş, Cenk; Kılıç, Ertuğrul (Galenos Yayıncılık, 2019)Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ... -
Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo
Doǧan, Ayşegül; Demirci, Selami; Çağlayan, Ahmet Burak; Kılıç, Ertuğrul; Günal, Mehmet Yalçın; Uslu, Ünal; Cumbul, Alev; Şahin, Fikrettin (Humana Press, 2014)After a disruption of skin integrity, the body produces an immediate response followed by a functional and comparable regeneration period, referred to as wound healing. Although normal wounds do not need much attention ... -
Squalene attenuates the oxidative stress and activates AKT/mTOR pathway against cisplatin-induced kidney damage in mice
Sakul, Arzu; Ozansoy, Mehmet; Elibol, Birsen; Ayla, Şule; Günal, Mehmet Yalçın; Yozgat, Yasemin; Basağa, Hüveyda; Şahin, Kazım; Kazancıoğlu, Rümeyza; Kılıç, Ulkan (Tubitak Scientific & Technical Research Council Turkey, 2019)The clinical use of cisplatin, which is a first-line anticancer agent, is highly restricted due to its adverse effects on kidneys that lead to nephrotoxicity. Therefore, some potential reno-protective substances have been ... -
Wound healing activity of arum maculatum
Arzu Şakul, Ayşe; Okur, Mehmet Evren; Ayla, Şule; Daylan, Benay; Karadağ, Ayşe Esra; Batur, Şebnem; Özdemir, Ekrem Musa; Altınalan, Ebrar; Günal, Mehmet Yalçın (Istanbul Medeniyet University, 2023)Objective: In this study, the antioxidant properties of Arum maculatum plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of A. maculatum fruits. This study aimed ... -
Wound healing effects of methanol extract of Laurocerasus officinalis roem
Ayla, Şule; Okur, Mehmet Evren; Günal, Mehmet Yalçın; Özdemir, Ekrem Musa; Çiçek Polat, Derya; Yoltaş, Ayşegül; Biçeroğlu, Özge; Karahüseyinoğlu, Serçin (Taylor & Francis Ltd, 2019)Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using ...