Yazar "Berk, Barkın" için listeleme
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The importance of computerized drug interaction checker programs used in community pharmacies to avoid potential drug interactions: A preliminary study with clarithromycin
Şimşek, Abdullah; Taner, Neda; Macit, Çağlar; Berk, Barkın; Mercanoğlu, Güldem (Istanbul Training & Research Hospital, 2019)Introduction: Drug-drug interactions (DDI) due to multiple drug use are the most important cause of adverse drug reactions. DDIs are among medication errors that can be prevented. The integrated computerized drug interaction ... -
Investigation of hidden crisis of prescription drug abuse in Turkey: Pregabalin monitoring
Badur, İsa; Bilgin Badur, Naciye; Berk, Barkın (Istanbul Medipol University, 2022)This is a cross-sectional retrospective observational national study. Abuse/misuse of the pregabalin and related parameters analyzed. Pregabalin was mostly pre-scribed by general practitioners (26.2%). Pregabalin prescribing ... -
Kalp yetmezliği olan hastalarda farmasötik bakımın etkisi üzerine prospektif bir çalışma
Taner, Neda (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Bu çalışmanın amacı, kalp yetmezliği bulunan hastalarda klinik eczacının sunacağı farmasötik bakım hizmetleri kapsamında hasta eğitiminin ilaç uyuncuna, ilaçla ilgili problemler (İİP)'e ve yaşam kalitesine etkisini ... -
Klaritromisin kullanan pediatrik hastalarda ilaç-ilaç etkileşimi
Şimşek, Abdullah (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)İlaç-ilaç etkileşimleri pediatrik hastalarda önem kazanmaktadır. Pediatrik hastaların sık kullandıkları ilaç gruplarından biri de antibiyotiklerdir. Makrolid grubu antibiyotikler alt ve üst solunum yolu, yumuşak doku ve ... -
Kocaeli ili Çayırova ilçesindeki serbest eczanelerden karşılanan valproik asit ve türevi ilaçların reçeteleme kaynaklı problemlerinin tespiti
Zeydan, Güzide Gülsüm (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)İlaçların yararları olduğu gibi uygun kullanılmadığında zararları da olabilmekte-dir. Reçetelerdeki hatalardan kaynaklı ilaç- ilaç etkileşimleri veya ilaç hastalık etkile-şimlerine sık rastlanmaktadır. Ülkemizde klinik ... -
Makrolid grubu antibiyotik kullanan hastalarda ilaç etkileşim sıklığının değerlendirilmesi
Öncülokur, Merve (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)1930'lu yıllarda sülfonamidlerin keşfi ile mikroorganizmalara karşı modern kemoterapinin ilk kullanımı başlamıştır. Antimikrobiyaller arasında yer alan makrolidler; solunum yolu infeksiyonları, pnömoni, deri ve yumuşak ... -
Molecular modelling and activity analysis of mycobacterium tuberculosis DNA gyrase B ATPase active site
Berk, Barkın; Şahin, Zafer (University of Istanbul, 2017)Computer-based algorithms and statistical techniques such as receiver operating characteristic (ROC) curves are increasingly used for the design of new ligands. X-ray crystallographic data and homology models allow examining ... -
Molecular modelling and compound activity of the escherichia coli and staphylococcus aureus DNA gyrase B ATPase site
Berk, Barkın; Kaynar, Gürmen; Ertaş, Merve; Biltekin, Sevda Nur (University of Istanbul, 2017)Development of new treatment ligands that can distinguish Escherichia coli (E. coli) from Staphylococcus aureus (S. aureus) is important because of bacterium multiple drug resistance. High-throughput virtual screening ... -
Monosit/hdl-kolesterol oranının kalp yetmezliği ile ilişkisinin klinik eczacılık açısından değerlendirilmesi
Çattık, Büşra Nur (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Monosit/HDL-kolesterol oranı (MHR) inflamasyonla ilişkili bir değerdir. Bu çalışmada inflamasyonla ilişkili bir hastalık olan kalp yetmezliğinin şiddeti ve tedavisi ile ilişkili bir belirteç olarak kullanımı değerlendirilmiştir. ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Küçükkılınç, Tuba Tüylü; Demirayak, Şeref (Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Özhan, Yağmur; Sipahi, Hande; Gao, Zhanguo; Jacobson, Kenneth A.; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ... -
Novel thiazole-piperazine derivatives as potential cholinesterase inhibitors
Demirayak, Şeref; Şahin, Zafer; Ertaş, Merve; Bülbül, Emre Fatih; Bender, Ceysu; Biltekin, Sevde Nur; Berk, Barkın; Sağlık, Begüm Nurpelin; Levent, Serkan; Yurttaş, Leyla (Wiley, 2019)Dementia is a cognitive disorder mostly associated with Alzheimer's disease (AD) in addition to being seen in many other diseases of the central nervous system (CNS). The limited number of drugs is not sufficient to provide ... -
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
Ertaş, Merve; Şahin, Zafer; Bülbül, Emre Fatih; Bender, Ceysu; Biltekin, Sevde Nur; Berk, Barkın; Yurttaş, Leyla; Nalbur, Aysu M.; Çelik, Hayati; Demirayak, Şeref (Wiley, 2019)The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and ... -
Prescribing pattern of PPI and clopidogrel in community pharmacies in Turkey
Karataş Koçberber, Emine; Abunahlah, Nibal; Berk, Barkın (Springer, 2016)Background & Objectives: Proton Pump Inhibitors (PPIs) are among the most prescribed medications in Turkey. The use of proton pump inhibitors is one of the risk factors associated with treatment failure or unresponsiveness ... -
Prognostic significance of tumor tissue NeuGcGM3 ganglioside expression in patients receiving racotumomab immunotherapy
Üskent, Necdet; Ayla, Şule; Molinas Mandel, Nil; Özkan, Metin; Teomete, Mehmet; Baloğlu, Hüseyin; Aydinçer, Cenk; Yergök, Hale; Doğan, Ender; Berk, Barkın; Yazar, Aziz (Hindawi Ltd., 2020)Expression ofN-glycolyl GM3 (NeuGcGM3) ganglioside was detected in the tumor specimens of patients who were on Racotumomab anti-idiotype vaccine maintenance treatment, and prognostic significance as a biomarker was ... -
Prognostic significance of tumour tissue NeuGcGM3 ganglioside expression and predictive value of circulating tumour cell count monitoring in patients receiving racotumomab immunotherapy
Üskent, Necdet; Ayla, Şule; Mandel, Nil Molinas; Özkan, Metin; Teomete, Mehmet; Baloğlu, Hüseyin; Aydinçer, Cenk; Yergök, H.; Doğan, Erkan; Berk, Barkın; Yazar, Aziz (Oxford University Press, 2019)... -
A prospective study concerning the effect of pharmaceutical care services on patients with heart failure
Taner, Neda; Berk, Barkın (Marmara University, 2022)Objective: Heart failure (HF), caused by an abnormality in cardiac function, is the inability of heart tissue to pump blood or deliver sufficient oxygen, resulting in abnormal diastolic volume. Drug-Related Problems (DRPs) ... -
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
Ertaş, Merve; Şahin, Zafer; Berk, Barkın; Yurttaş, Leyla; Biltekin, Sevde Nur; Demirayak, Şeref (Wiley-VCH Verlag, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
Şahin, Zafer; Ertaş, Merve; Berk, Barkın; Biltekin, Sevde Nur; Yurttaş, Leyla; Demirayak, Şeref (Pergamon-Elsevier Science Ltd, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ...