Yazar "Beker, Mustafa Çağlar" için listeleme
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Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
Beker, Mustafa Çağlar; Pençe, Mahmud Esad; Yağmur, Sümeyya; Çağlayan, Berrak; Çağlayan, Aysun; Kılıç, Ülkan; Yelkenci, Hayriye Ecem; Altıntaş, Mehmet Özgen; Çağlayan, Ahmet Burak; Doeppner, Thorsten Roland; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc., 2022)The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Altunay, Serdar; Özbay, Elif; Ateş, Nilay; Keleştemur, Taha; Çağlayan, Berrak; Kılıç, Ülkan; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
Ateş, Nilay; Çağlayan, Aysun; Balçıkanlı, Zeynep; Sertel, Elif; Beker, Mustafa Çağlar; Dilsiz, Pelin; Çağlayan, Ahmet Burak; Çelik, Süleyman; Daşdelen, Muhammed Furkan; Çağlayan, Berrak; Yiğitbaşı, Türkan; Özbek, Hanefi; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke
Kılıç, Ertuğrul; Çaǧlayan, Berrak; Beker, Mustafa Çağlar (NLM (Medline), 2020)Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood ... -
Pleiotropic and renoprotective effects of erythropoietin beta on experimental diabetic nephropathy model
Eren, Zehra; Günal, Mehmet Yalçın; Arı, Elif; Çoban, Jale; Çakalağaoğlu, Fulya; Çağlayan, Burak; Beker, Mustafa Çağlar; Akdeniz, Tuba; Yanıkkaya, Gülderen; Kılıç, Ertuğrul; Kantarcı, Gülçin (Karger, 2016)Background: This study aimed at investigating the possible protective effect of erythropoietin beta on experimental diabetic nephropathy (DN) model in rats. Methods: Sprague Dawley rats (n = 32) were allocated into 4 equal ... -
Poloxamer P85 increases anticancer activity of schiff base against prostate cancer in vitro and in vivo
Demirci, Selami; Doğan, Ayşegül; Türkmen Bacak, Neşe; Telci, Dilek; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kılıç, Ertuğrul; Özkan, Ferda; Dede, Bülent; Şahin, Fikrettin (Lippincott Williams and Wilkins, 2017)Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective ... -
Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity
Gürler, Gökçe; Belder, Nevin; Beker, Mustafa Çağlar; Sever Bahçekapılı, Melike; Uruk, Gökhan; Kılıç, Ertuğrul; Yemişçi, Müge (BioMed Central Ltd, 2023)BackgroundReduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development. While folate deficiency ... -
The role of circadian rhythm in the regulation of cellular protein profiles in the brain
Beker, Mustafa Çağlar; Kılıç, Ertuğrul (The Scientific and Technological Research Council of Turkey, 2021)Background/aim: Circadian rhythm plays a significant role in the regulation of almost all kinds of physiological processes. In addition, it may also have a direct or indirect effect on the neurodegenerative processes, ... -
The role of repetative transcranial magnetic stimulation after focal cerebral ischemia
Çağlayan, Ahmet Burak; Yalçın, Esra; Altunay, Serdar; Sertel, Elif; Dilden, Aysun; Karaçay, Reyda; Beker, Mustafa Çağlar; Keleştemur, Taha; Çağlayan, Berrak; Kutlu, Selim; Kılıç, Ülkan; Kılıç, Ertuğrul (Wiley, 2017)... -
Short-term diet restriction but not alternate day fasting prevents cisplatin-induced nephrotoxicity in mice
Günebakan, Evrin; Yalçın, Esra; Çikler Dülger, Esra; Yiğitbaşı, Ahmet; Ateş, Nilay; Çağlayan, Aysun; Beker, Mustafa Çağlar; Şahin, Kâzim; Korkaya, Hasan; Kılıç, Ertuğrul (MDPI AG, 2020)Cisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, ... -
Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses
Daşdelen, Muhammed Furkan; Çağlayan, Ahmet Burak; Er, Sezgin; Beker, Mustafa Çağlar; Ateş, Nilay; Gronewold, Janine; Doeppner, Thorsten Roland; Hermann, Dirk M.; Kılıç, Ertuğrul (Academic Press Inc., 2024)Social isolation is associated with poor stroke outcome, but the underlying molecular mechanisms were largely unknown. In male Balb/C mice exposed to transient middle cerebral artery occlusion (MCAo), we examined the effects ... -
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy
Beker, Mustafa Çağlar; Beker, Merve; Çağlayan, Ahmet Burak; Bolat, Busenur; Kılıç, Ülkan; Köse, Gamze; Kılıç, Ertuğrul (Turkey Clinics, 2022)Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the ...