Yazar "Beker, Mustafa Çağlar" için listeleme
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ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
Rohlfing, Anne-Katrin; Kolb, Kyra; Sigle, Manuel; Ziegler, Melanie; Bild, Alexander; Münzer, Patrick; Sudmann, Jessica; Dicenta, Valerie; Harm, Tobias; Manke, Mailin-Christin; Geue, Sascha; Kremser, Marcel; Chatterjee, Madhumita; Liang, Chunguang; Eysmondt, Hendrik von; Dandekar, Thomas; Heinzmann, David; Günter, Manina; Ungern-Sternberg, Saskia von; Büttcher, Manuela; Castor, Tatsiana; Mencl, Stine; Langhauser, Friederike; Sies, Katharina; Ashour, Diyaa; Beker, Mustafa Çağlar; Lämmerhofer, Michael; Autenrieth, Stella E.; Schäffer, Tilman E.; Laufer, Stefan; Szklanna, Paulina; Maguire, Patricia; Heikenwalder, Matthias; Müller, Karin Anne Lydia; Hermann, Dirk M.; Kılıç, Ertuğrul; Stumm, Ralf; Ramos, Gustavo; Kleinschnitz, Christoph; Borst, Oliver; Langer, Harald F.; Rath, Dominik; Gawaz, Meinrad (Nature Research, 2022)Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Yalçın, Esra; Çağlayan, Aysun; Yuluğ, Burak; Hanoğlu, Lütfü; Kutlu, Selim; Doeppner, Thorsten Roland; Hermann, Dirk Matthias; Kılıç, Ertuğrul (Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Age-associated resilience against ischemic injury in mice exposed to transient middle cerebral artery occlusion
Beker, Mustafa Çağlar; Aydınlı, Fatmagül İlayda; Çağlayan, Ahmet Burak; Beker, Merve; Baygül, Oğuzhan; Çağlayan, Aysun; Popa-Wagner, Aurel; Doeppner, Thorsten R.; Hermann, Dirk M.; Kılıç, Ertuğrul (Springer, 2023)Ischemic stroke is the leading cause of death and disability. Although stroke mainly affects aged individuals, animal research is mostly one on young rodents. Here, we examined the development of ischemic injury in young ... -
BMAl1'in beyin hasarı sonrası rolününproteomik açıdan incelenmesi
Özbay, Elif (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Sirkadiyen ritim, iç ve dış uyaranlara bağlı olarak hemen hemen tüm fizyolojik durumlarımızı kontrol eden önemli bir biyolojik saattir. Bunun yanı sıra, sirkadiyen ritmin özellikle beyin felci gibi nörodejeneratif hastalıkların ... -
Can Carpobrotus edulis, heal incisional and excisional wounds on the skin?
Günal, Mehmet Yalçın; Şahinler Ayla, Sibel; Çaglayan, Berrak; Beker, Mustafa Çağlar; Bedri, Nejda; Aslan, İpek Bilge; Özdemir, Ekrem Musa; Kılıç, Ertuğrul; Yeşilada, Elif (Comenius University, 2021)OBJECTIVES: This study aimed to investigate the wound healing activity of liposomal Carpobrotus edulis powder extract (CEPE) formulation on incisional and excisional wounds in rat. BACKGROUND: In the event of any damage, ... -
Delayed therapeutic administration of melatonin enhances neuronal survival through AKT and MAPK signaling pathways following focal brain ischemia in mice
Kılıç, Ülkan; Elibol, Birsen; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Beker, Merve; Altuğ Tasa, Burcugül; Uysal, Ömer; Yılmaz, Bayram; Kılıç, Ertuğrul (Springer Nature, 2022)Melatonin has a role in the cell survival signaling pathways as a candidate for secondary stroke prevention. Therefore, in the present study, the coordination of ipsilateral and contralateral hemispheres to evaluate delayed ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
Verimli, Nihan; Goralı, Selen İrem; Abişoğlu, Beyza; Altan, Cem Levent; Sucu, Bilgesu Onur; Karataş, Ersin; Tülek, Ahmet; Bayraktaroğlu, Çiğdem; Beker, Mustafa Çağlar; Erdem, Sultan Sibel (Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ... -
Dual action of exosomes derived from in vitro A beta toxicity model: The role of age for pathological response
Beker, Merve; Günay, Necmeddin; Sarıkamış, Bahar; Kalkan Çakmak, Rabia; Erçin, Nilüfer; Altıntaş, Mehmet Özgen; Altunay, Serdar; Beker, Mustafa Çağlar; Sarı Ak, Duygu; Kılıç, Ülkan (Elsevier Ireland Ltd, 2023)Exosomes released from different cell types of the central nervous system play an essential role in the patho-genesis of Alzheimer's disease (AD). In this study, we aimed to create an animal model by injecting exosomes ... -
Effect of social isolation on the brain injury following focal cerebral ischemia in mice and proteomic approach for identifying possible cellular pathways
Çağlayan, Ahmet Burak; Daşdelen, Muhammed Furkan; Beker, Mustafa Çağlar; Özbay, Erkan; Kılıç, E. (Wiley, 2021)Social isolation has become a significant part of our everyday life during the Covid-19 pandemic, resulting in drastic effects on physiological wellbeing. It was shown that loneliness or psychosocial stress such as social ... -
Effects of neurotrophic factors cdnf and manf on brain plasticity and repair after brain ischemia
Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Çağlayan, Berrak; Altunay, Serdar; Dalay, Arman; Dilden, Aysun; Sertel, Elif; Keleştemur, Taha; Yalçın, Esra; Kılıç, Ülkan; Saarma, Mart; Kılıç, Ertuğrul (Wiley-Blackwell, 2016)... -
The effects of topical liposomal resveratrol on incisional and excisional wound healing process
Günal, Mehmet Yalçın; Ayla, Şule; Bedri, Nejda; Beker, Mustafa Çağlar; Çağlayan, Ahmet Burak; Aslan, İsmail; Özdemir, Ekrem Musa; Yeşilada, Erdem; Kılıç, Ülkan (Turkish Society of Dermatology and Venereology, 2019)Background and Design: The objective of this study was to investigate the wound healing activity of different concentrations of liposomal trans-resveratrol formulations on incisional and excisional wounds in rats. Materials ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ...