Yazar "Üstündağ Okur, Neslihan" için listeleme
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Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
Arpa, Muhammet Davut; Seçen, İkbal Merve; Erim, Ümit Can; Hoş, Ayşegül; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2022)In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
Arpa, Muhammet Davut; Üstündağ Okur, Neslihan; Gök, Mehmet Koray; Özgümüş, Saadet; Cevher, Erdal (Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Comparison of intestinal permeability of nebivolol hydrochloride loaded solid lipid nanoparticles with commercial nebivolol tablet
Gökçe, Evren Homan; Kaynak, Mustafa Sinan; Yurdasiper, Aysu; Üstündağ Okur, Neslihan; Şahin, Selma (Marmara University, 2018)The oral application of drugs is the most popular route for achieving systemic effects, nevertheless, it is limited by difficulties related to physicochemical properties of the drug. Solid lipid nanoparticles (SLNs) are ... -
Current status of mucoadhesive gel systems for buccal drug delivery
Üstündağ Okur, Neslihan; Özcan Bülbül, Ece; Yağcılar, Ayşe Pınar; Siafaka, Panoraia I (Bentham Science Publishers Ltd, 2021)Background: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, ... -
Detecting and targeting neurodegenerative disorders using electrospun nanofibrous matrices: Current status and applications
Siafaka, Panoraia I.; Özcan Bülbül, Ece; Dilsiz, Pelin; Karantas, Ioannis D.; Okur, Mehmet Evren; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2021)Neurodegeneration is defined as the progressive atrophy and loss of function of neurons; it is present in neurodegenerative disorders such as Multiple Sclerosis, Alzheimer's, Huntington's, and Parkinson's diseases. The ... -
Development and characterization of voriconazole loaded in situ gel formulations for ophthalmic application
Üstündağ Okur, Neslihan; Yoltaş, Ayşegül; Yozgatlı, Vildan (Turkish Pharmacists Assoc, 2016)The aim of the this research was to prepare and evaluate the potential use of in situ gel formulations for ocular delivery of voriconazole for the treatment of fungal keratitis. An in situ gelling system was used to increase ... -
Development and validation of an HPLC method for voriconazole active substance in bulk and its pharmaceutical formulation
Üstündağ Okur, Neslihan; Çağlar, Emre Sefik; Yozgatlı, Vildan (Marmara University, 2016)The aim of the present study was to develop and validate a High-Performance Liquid Chromatography (HPLC) method for the determination of voriconazole in drug substances and in situ gel. A mixture of acetonitrile and ultrapure ... -
Development, characterization of naringenin-loaded promising microemulsion formulations, and demonstration of anti-aging efficacy by in vitro enzyme activity and gene expression
Şahin, Dilara; Çağlar, Emre Şefik; Boran, Tuğçe; Karadağ, Ayşe Esra; Özhan, Gül; Üstündağ Okur, Neslihan (Editions de Sante, 2023)This study aims to produce microemulsion formulations containing naringenin for anti-aging reasons. For this purpose, formulations of topical microemulsions including different cosurfactants and surfactants were developed, ... -
Effect of microemulsion formulation on biodistribution of Tc-99m-Aprotinin in acute pancreatitis models induced rats
İlem Özdemir, Derya; Üstündağ Okur, Neslihan; Ay Şenyiğit, Zeynep; Oruç, Nevin; Aşıkoğlu, Makbule; Özütemiz, Ömer; Karasulu Yeşim, Hatice (Taylor & Francis, 2016)Background: Aprotinin is a monomeric globular polypeptide, which derived from bovine lung tissue and theoretically attractive molecule in ameliorating the effects of acute pancreatitis. Acute pancreatitis is an inflammatory ... -
Evaluation of in situ gel containing pycnogenol for cutaneous wound healing
Okur, Mehmet Evren; Ayla, Şule; Batur, Şebnem; Yoltaş, Ayşegül; Genç, Ecem; Pertek, Sinem; Üstündağ Okur, Neslihan (Logos Medical Publishing, 2019)Aim: Pycnogenol® (PYC) are used for various medicinal purposes. The aims of the present study were toevaluate wound healing activity of PYC loaded in situ gel in mice and to investigate its antibacterial activity.Method: ... -
Formulation of microemulsions for dermal delivery of Cephalexin
Üstündağ Okur, Neslihan; Er, Sevda; Çağlar, Emre Şefik; Ekmen, Tarık Ziya; Sala, Furkan (University of Istanbul, 2017)Introduction: Cephalexin monohydrate (CEM) is mostly used because of its activity against both the gram-positive and gram-negative microorganisms for infections. Microemulsions offer numerous advantages for dermal delivery ... -
Hemostatic activity of cistus creticus extract in wistar albino rats
Karadağ, Ayşe Esra; Çaşkurlu, Ayşegül; Okur, Mehmet Evren; Güzelmeriç, Etil; Üstündağ Okur, Neslihan; Tosun, Fatma; Yeşilada, Erdem; Demirci, Fatih (Springer Nature, 2020)Aerial part preparations of Cistus creticus L., Cistaceae, are traditionally used in Anatolia as a hemostatic agent. The air-dried aerial parts were extracted with methanol. Gels were prepared, followed by the hemostatic ... -
Improving therapeutic efficacy of voriconazole against fungal keratitis: Thermo-sensitive in situ gels as ophthalmic drug carriers
Üstündağ Okur, Neslihan; Yozgatlı, Vildan; Okur, Mehmet Evren; Yoltaş, Ayşegül; Siafaka, Panoraia, I. (Elsevier Science Bv, 2019)The aim of this research was to evaluate the potential use of in situ gel formulations for voriconazole ocular delivery as fungal keratitis treatment. The in situ gelling system was applied to increase residence time and ... -
In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Üstündağ Okur, Neslihan; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Demirci, Betül; Demirci, Fatih (MDPI, 2020)The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana ... -
Investigation of antimicrobial activities of some herbs containing essential oils and their mouthwash formulations
Kulaksız, Büşra; Er, Sevda; Üstündağ Okur, Neslihan; Saltan İşcan, Gülçin (Turkish Pharmacists Association, 2018)Objectives: The aim of this study was to prepare pharmaceutical formulations of mouthwashes and to examine the antimicrobial activities of essential oils obtained from plants used traditionally in Turkey for oral infections. ... -
İstanbul İli, ümraniye ilçesindeki kontrole tabi ilaçların akılcı ilaç kullanımı açısından araştırılması
Badur, İsa (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Bu farmakoepidemiyoloji çalışması içeriğinde kontrole tabi ilaç reçeteleri akılcı ilaç uygulamaları açısından incelenmektedir. Çalışma kesitsel gözlemsel olup, ilaç kullanımı retrospektif olarak araştırılmaktadır. 2014 ... -
Kozmetik preparatlar ve kozmetik preparatlarda kullanılan bitkiler
Üstündağ Okur, Neslihan; Karadağ, Ayşe Esra; İpekçi, Esra; Bülbül, Ece (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş., 2020)Bitkilerden elde edilen ekstreler ve fitokimyasallar, geçmişten günümüze farmasötik ve kozmetik alanda kullanılan preparatların içeriğinde yer almışlardır. Özellikle kozmetik preparatlarda, son za-manlarda doğal içerikli ... -
Melazma tedavisi için çeşitli dermal formülasyonların tasarlanması
Pekcan, Ahmet Nezihi (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Çalışmamızdaki amacımız, melazma tedavisinde kullanılan hidrokinon maddesinin mikroemülsiyon taşıyıcı sistemlerle alternatif yeni taşıyıcı sistemlerin geliştirilmesi ve bu formülasyonların in vitro olarak değerlendirilmesidir. ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Arpa, Muhammet Davut; Yoltaş, Ayşegül; Onay Tarlan, Ecehan; Şahin Şenyüz, Cemre; Sipahi, Hande; Aydın, Ahmet; Üstündağ Okur, Neslihan (Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
Üstündağ Okur, Neslihan; Filippousi, Maria; Okur, Mehmet Evren; Ayla, Şule; Çağlar, Emre Şefik; Yoltaş, Ayşegül; Siafaka, Panoraia I (Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ...