Yazar "Öztürk, Gürkan" için listeleme
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Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl ambystoma mexicanum
Demircan, Turan; İlhan, Ayşe Elif; Ovezmyradov, Guvanch; Öztürk, Gürkan; Yıldırım, Süleyman (Nature Publishing Group, 2019)The Mexican axolotl (Ambystoma mexicanum) is a critically endangered species and a fruitful amphibian model for regenerative biology. Despite growing body of research on the cellular and molecular biology of axolotl limb ... -
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators
Yang, Hong; Li, Xiangyu; Jin, Han; Türkez, Hasan; Öztürk, Gürkan; Doğanay, Hamdi Levent (Elsevier Inc., 2023)Growing evidence suggests that the depletion of plasma NAD+ and glutathione (GSH) may play an important role in the development of metabolic disorders. The administration of Combined Metabolic Activators (CMA), consisting ... -
Mesenchymal stem cell-based COVID-19 therapy: Bioengineering perspectives
Karakaş, Nihal; Üçüncüoğlu, Süleyman; Uludağ, Damla; Karaoğlan, Birnur Sinem; Shah, Khalid; Öztürk, Gürkan (MDPI, 2022)The novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) are currently utilized in clinics for pulmonary inflammatory ... -
Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon
Sibai, Mustafa; Altuntaş, Ebru; Yıldırım, Berna; Öztürk, Gürkan; Yıldırım, Süleyman; Demircan, Turan (Mary Ann Liebert Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
Mikro elektrot düzeneği ve optogenetik araçlar kullanılarak hipokampal nöronlarda bellek oluşumunun incelenmesi
Bostan, Sevginur (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Sinirsel ağların sergilediği özelliklerin elektrofizyolojik olarak incelenmesi, öğrenme, bellek oluşumu ve sinirsel kodlama gibi konuları araştırmak için esnek ve verimli bir platform sağlar. Öğrenme ve bellek oluşumunun ... -
Modulation of excitability of stellate neurons in the ventral cochlear nucleus of mice by atp-sensitive potassium channels
Bal, Ramazan; Öztürk, Gürkan; Önalan Etem, Ebru; Him, Aydın; Cengiz, Nurettin; Kuloǧlu, Tuncay; Tuzcu, Mehmet; Yıldırım, Caner; Tektemur, Ahmet (Springer, 2018)Major voltage-activated ionic channels of stellate cells in the ventral part of cochlear nucleus (CN) were largely characterized previously. However, it is not known if these cells are equipped with other ion channels apart ... -
Modulation of the excitability of stellate neurons in the ventral cochlear nucleus of mice by TRPM2 channels
Bal, Ramazan; Öztürk, Gürkan; Önalan Etem, Ebru; Eraslan, Ersen; Özaydın, Seda (Elsevier, 2020)Oxidative stress-induced Ca2+ permeable transient receptor potential melastatin 2 (TRPM2) channels are expressed at high levels in the brain, appear to link neuronal excitability to cellular metabolism, and are involved ... -
Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
Karakaş, Nihal; Bay, Sadık; Türkel, Nezaket; Öztunç, Nurşah; Öncül, Merve; Bilgen, Hülya; Shah, Khalid; Şahin, Fikrettin; Öztürk, Gürkan (Public Library of Science, 2020)Mesenchymal stem cells have the ability to transdifferentiate into neurons and therefore one of the potential adult stem cell source for neuronal tissue regeneration applications and understanding neurodevelopmental ... -
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
Yılmaz, Elif Nur; Bay, Sadık; Öztürk, Gürkan; Uçışık, Mehmet Hikmet (Dove Medical Press Ltd, 2020)Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ... -
The neuroprotective effects of hypothermia on bilirubin-ınduced neurotoxicity in vitro
Kuter, Nazlı; Ayşit-Altuncu, Neşe; Öztürk, Gürkan; Özek, Eren (Karger, 2018)Background: In high-risk newborns indirect hyperbilirubinennia can lead to acute bilirubin encephalopathy and kernicterus. Despite the current therapeutic modalities, preventing or reversing the neurotoxicity cannot be ... -
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels
Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier B.V., 2022)Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation ... -
Nitric oxide biosensor uncovers diminished ferrous iron-dependency of cultured cells adapted to physiological oxygen levels (vol 53, 102319, 2022)
Sevimli, Gülşah; Smith, Matthew J.; Akgül Çağlar, Tuba; Bilir, Şükriye; Seçilmiş, Melike; Altun, Hamza Y.; Yiğit, Esra N.; Yang, Fan; Keeley, Thomas P.; Malli, Roland; Öztürk, Gürkan; Mann, Giovanni E.; Eroğlu, Emrah (Elsevier, 2022)The authors regret that the cited reference list in the online PDF of this article contains a duplicate reference (Ref 34 and incomplete Ref 56). Ref 56 should read as follows. -
A pooled RT-PCR testing strategy for more efficient Covid-19 pandemic management
Ayaz, Akif; Öztürk Demir, Aslı Güner; Öztürk, Gürkan; Koçak, Mehmet (Elsevier, 2022)Objectives: RT-PCR testing is indispensable in Covid-19 pandemic management. With the spread of the pandemic with emerging variants, the RT-PCR capacity is overburdened and new strategies and capabilities need to be ... -
Preclinical molecular signatures of spinal cord functional restoration: Optimizing the metamorphic axolotl (ambystoma mexicanum) model in regenerative medicine
Demircan, Turan; Hacıbektaşoğlu, Harbiye; Sibai, Mustafa; Cana Fesçioğlu, Ece; Altuntaş, Ebru; Öztürk, Gürkan; Süzek, Barış Ethem (Mary Ann Liebert, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
Sinir hücreleri ile kalp kası hücreleri arasındaki etkileşimin moleküler ve elektrofizyolojik düzeyde araştırılması
Akgül Çağlar, Tüba (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2021)Kalbe dallanan otonom sinir sistemi ve duyu nöronları kalp kası hücreleri (kardiyomiyosit) ve kalbin çalışmasını düzenler. Kalpte oluşan ağrı, basınç ve gerilme gibi duyusal bilgilerin bağlantılı olduğu arka kök gangliyon ... -
Strategies for development, management and funding of scientific projects
Öztürk, Gürkan; Ayar, Ahmet; Gözay, Ozge; Yılmaz, Bayram (Wiley-Blackwell, 2015)In the academic environment the number of scientists is continuously increasing so the number of scientific projects seeking funding. This competition is at a higher level than before. Attempts for obtaining funding and ... -
Transfer and integration of breast milk stem cells to the brain of suckling pups
Aydın, Mehmet Şerif; Yiğit, Esra Nur; Vatandaşlar, Emre; Erdoğan, Ender; Öztürk, Gürkan (Nature Publishing Group, 2018)Beside its unique nutritional content breast milk also contains live cells from the mother. Fate of these cells in the offspring has not been adequately described. In this study, we aimed to detect and identify maternal ...