Yazar "Öztürk, Gürkan" için listeleme
-
Endojen opioid reseptörlerin dinamiğinin araştırılması
Baydaş, Gülsena (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2018)Nöronal hasar, ağrı ve dejenerasyon olarak sonuçlanan önemli rahatsızlıklardan bir tanesidir. Bu tür ağrıların tedavisinde kullanılan morfin benzeri ilaçlar opioid olarak adlandırılmaktadır ve etkilerini kendilerine özgü ... -
Enhancement of cultured adult motor neuron survival with cold pre-incubation
Bektaş, Serap; Öztürk, Gürkan (Elsevier Ireland Ltd, 2013)The aim of the study was to extend the survival of adult spinal motor neurons in serum free culture. Anterior half of the spinal cord was removed from young adult mice and dissociated. Cultured cells attempted to extend ... -
ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target
Demir, Özlem; Aysit, Neşe; Önder, Zeynep; Türkel, Nezaket; Öztürk, Gürkan; Sharrocks, Andrew D.; Aksan Kurnaz, Işıl (Elsevier, 2011)Elk-1 belongs to the ternary complex factors (TCFs) subfamily of the ETS domain proteins, and plays a critical role in the expression of immediate-early genes (IEGs) upon mitogen stimulation and activation of the ... -
Evaluation of the bilateral cardiac afferent distribution at the spinal and vagal ganglia by retrograde labeling
Akgül Çağlar, Tuba; Durdu, Zeynep Begüm; Turhan, M. U.; Günal, Mehmet Yalçın; Aydın, Mehmet Şerif; Öztürk, Gürkan; Çağavi, Esra (Elsevier, 2021)The identity of sensory neurons innervating the heart tissue and the extent of information reported to the brain via these neurons are poorly understood. In order to evaluate the multidimensional distribution and abundance ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
Çağlayan, Berrak; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Yalçın, Esra; Beker, Merve; Keleştemur, Taha; Sertel, Elif; Öztürk, Gürkan; Kılıç, Ülkan; Şahin, Fikrettin; Kılıç, Ertuğrul (Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Experimental data of labeling the heart and cardiac cultures with a retrograde tracer in vitro and in vivo
Akgül Çağlar, Tuba; Günal, Mehmet Yalçın; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Elsevier Inc., 2021)Retrograde dyes are often used in basic research to investigate neuronal innervations of an organ. This article describes the experimental data on the application of retrograde dyes on the mouse heart in vivo and on the ... -
Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota
Demircan, Turan; Ovezmyradov, Guvanch; Yıldırım, Berna; Keskin, İlknur; İlhan, Ayşe Elif; Fesçioğlu, Ece Cana; Öztürk, Gürkan; Yıldırım, Süleyman (Nature Publishing Group, 2018)Axolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis ... -
Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation
Kandemir, Başak; Davis, Sabrina; Yiğit, Esra Nur; Öztürk, Gürkan; Yılmaz, Bayram; Laroche, Serge; Aksan Kurnaz, Işıl (Elsevier Ireland Ltd, 2020)Pea3 proteins belong to a subfamily of the E-twentysix (ETS) domain superfamily of transcription factors, which play various roles during development. Polyoma Enhancer-Activator 3 (Pea3) proteins Pea3, ERM and Er81 are ... -
Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting
Shahbazi, Reza; Özçicek, İlyas; Öztürk, Gürkan; Ulubayram, Kezban (Iop Publishing Ltd, 2017)It is generally known that gold nanoparticles are localised in the cytoplasm and, if synthesised in small sizes or functionalized with specific proteins, they enter the cell nucleus. However, there is no report emphasising ... -
Hayvansal kaynaklı beslenmenin fare davranışları üzerine etkisi
Akyol, Esra (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Beslenme insanların en elzem gereksinimlerinin başında gelmektedir ancak temel bir ihtiyaç olmaktan çok daha fazlasıdır. Beslenme alışkanlıklarımızın bizi davranışsal olarak nasıl etkilediğinin, genlerimiz, bilişsel ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
Göktaş Şahoğlu, Sevilay; Kazcı, Yusuf Enes; Karadoğan, Behnaz; Aydın, Mehmet Şerif; Nebol, Aylin; Turhan, Mehmet Uğurcan; Öztürk, Gürkan; Çağavi, Esra (Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
Demircan, Turan; İlhan, Ayşe Elif; Aytürk, Nilüfer; Yıldırım, Berna; Öztürk, Gürkan; Keskin, İlknur (Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
HMG-CoA reductase inhibition promotes neurological recovery, peri-lesional tissue remodeling, and contralesional pyramidal tract plasticity after focal cerebral ischemia
Kılıç, Ertuğrul; Reitmeir, Raluca; Kılıç, Ülkan; Çağlayan, Ahmet Burak; Beker, Mustafa Çağlar; Kelestemur, Taha; Ethemoğlu, Muhsine Sinem; Öztürk, Gürkan; Hermann, Dirk M. (Frontiers Research Foundation, 2014)3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for secondary stroke prevention. Besides their lipid-lowering activity, pleiotropic effects on neuronal survival, angiogenesis, and ... -
An improved platform for cultured neuronal network electrophysiology: Multichannel optogenetics integrated with MEAs
Bayat, Fazlı Kemal; Alp, Muhammed İkbal; Bostan, Sevginur; Gülçür, Halil Özcan; Öztürk, Gürkan; Güveniş, Albert (Springer, 2022)Cultured neuronal networks (CNNs) are powerful tools for studying how neuronal representation and adaptation emerge in networks of controlled populations of neurons. To ensure the interaction of a CNN and an artificial ... -
An in vitro model for conditioning lesion effect
Kaval Oğuz, Elif; Öztürk, Gürkan (Springer/Plenum Publisher, 2019)Axons of a peripheral nerve grow faster after an axotomy if it attains a prior injury a few days earlier. This is called conditioning lesion effect (CLE) and very much valued since it may provide new insights into neuron ... -
In vitro transnöronal dejenerasyon mekanizmasında gen ifade değişiklikleri
Sefil, Şerife (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2015)Sinir sisteminin travmatik ve dejeneratif hasarları başlangıçta sınırlı sayıda hücreyi etkilese de daha sonra hasarın yakın ve uzak bölgelere "Transnöronal Dejenerasyon (TND)" adı verilen bir meknizmayla yayıldığı ... -
Integrative analysis of axolotl gene expression data from regenerative and wound healing limb tissues
Sibai, Mustafa; Parlayan, Cüneyd; Tuğlu, Pelin; Öztürk, Gürkan; Demircan, Turan (Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
Isolation and culture of adult mouse vestibular nucleus neurons
Him, Aydın; Altuntaş, Serap; Öztürk, Gürkan; Erdoğan, Ender; Cengiz, Nurettin (TUBITAK Scientific & Technical Research Council Turkey, 2017)Background/aim: Isolated cell cultures are widely used to study neuronal properties due to their advantages. Although embryonic animals are preferred for culturing, their morphological or electrophysiological properties ... -
The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline
Yalçınkaya, Ahmet S.; Şekeroğlu, Mehmet Ramazan; Huyut, Zübeyir; Çokluk, Erdem; Özbek, Hanefi; Öztürk, Gürkan; Balahoroğlu, Ragıp (Taylor & Francis Ltd, 2022)Objective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: ...