Yazar "Özbek, Hanefi" için listeleme
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Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
Karaarslan, Numan; Batmaz, Ahmet Güray; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Yaşar Şirin, Duygu; Kaplan, Necati; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)Non-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ... -
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
Çalışkan, Tezcan; Şirin, Duygu Yaşar; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Akyuva, Yener; Kaplan, Necati; Kaya, Yasin Emre; Şimşek, Abdullah Talha; Güzelant, Aliye Yıldırım; Ateş, Özkan (Spandidos Publications, 2019)The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
Keskin, İlknur; Günal, Mehmet Yalçın; Ayla, Şule; Kolbaşı, Bircan; Sayın Şakul, Arzu Ayşe; Kılıç, Ülkan; Gök, Özlem; Köroğlu, Kutay M.; Özbek, Hanefi (Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
The effects of rivaroxaban, an oral anticoagulant, on human IVD primary cultures
Çalışkan, Tezcan; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Termedia Publishing House Ltd, 2022)Introduction: The present study aimed to investigate the potential effects of rivaroxaban, an oral anticoagulant that inhibits the effects of factor Xa, on intact intervertebral disc tissue cells and the extracellular ... -
Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats
Parlar Köprülü, Rabia Edibe; Okur, Mehmet Evren; Kolbaşı, Bircan; Keskin, İlknur; Özbek, Hanefi (Brieflands, 2022)Background: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased ... -
Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice
Şakul, Ayşe Arzu; Kurtul, Ekin; Özbek, Hanefi; Kırmızı, Neriman İpek; Bahtiyar, Bade Cevriye; Saltan, Hayriye; Bahadır Acıkara, Özlem (Marmara University Faculty of Health Sciences, 2021)Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin ... -
Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Özbilgin, Serkan; Öz Ergene, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gülçin (Elsevier Masson SAS, 2017)Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced ... -
Evaluation of the antidiabetic activity of Alchemilla persica Rothm. In mice with diabetes induced by alloxan
Özbilgin, Serkan; Özbek, Hanefi; Kırmızı, Neriman İpek; Ergene Öz, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Saltan İşcan, Gülçin; Bahadır Acıkara, Özlem (Turkish Pharmacists Association, 2019)Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as ... -
Evaluation of the antidiabetic property of capparis ovata desf. Var. Palaestina zoh. Extracts using in vivo and in vitro approaches
Okur, Mehmet Evren; Çiçek Polat, Derya; Özbek, Hanefi; Yılmaz, Sezen; Yoltaş, Ayşegül; Arslan, Rana (Bentham Science Publ Ltd, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Evaluation of the effect of apixaban on the primary intact intervertebral disc cell cultures
Akgün, Feride Sinem; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Kaplan, Necati; Ateş, Özkan (2019)Aim: Apixaban is a frequently preferred pharmacological agent in clinics to prevent deep vein thrombosis and pulmonary embolism.Such new oral anticoagulants may cause hemorrhage’s in tissues and/or organs or may cause ... -
Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue
Kaplan, Necati; Yılmaz, İbrahim; Karaaslan, Numan; Yaşar Şirin, Duygu; Şimşek, Abdullah Talha; Çalışkan, Tezcan; Bircan, Rıfat; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using ... -
Evaluation of the expression and proliferation of degenerative markers in primary cell cultures obtained from human intervertebral disc tissue
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: A major cause of low back pain is disc degeneration. Nevertheless, no specific and reliable markers of the degeneration of the nucleus pulposus (NP) are available. This presented study aimed to examine changes in the ... -
Farmasötik inhaler sistemlerinin hasta kullanım becerilerinin incelenmesi
Albayrak, Ömer (İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Astım ve KOA hastalığına sahip hastaların tedavisinde endike olan bronkodilatörler ve steroidlerin farklı farmasötik formlarda uygulaması mevcuttur ancak en çok tercih edilen uygulama yolu inhalasyon şeklindedir. İnhalasyon ... -
Fiziksel engeli olan ve olmayan çocukların annelerinin yaşam kalitelerinin değerlendirilmesi
Aybarç, Umut (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Bu çalışma engelli çocuğa sahip olmanın annenin yaşamı üzerindeki etkilerini birçok açıdan ele almak amacıyla ilişkisel tarama metodu ile yapılmıştır. Çalışmaya 3- 17 yaş aralığında, fiziksel engelli raporlu ve bir özel ... -
Görev odaklı eğitimin romatoit artrit hastalarında kuvvet, ağrı ve becerikliliğe etkisi
Özçelep, Ömer Faruk (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Bu çalışma, görev odaklı eğitimin romatoid artritli hastalarda ağrı, kuvvet ve beceriklilik üzerine olan etkisini araştırmak amacıyla tasarlanmıştır. Çalışmaya romatoid artrit tanısı almış 46 birey dahil edilmiştir. Bireyler ... -
Hematopoetik kök hücre nakli esnasında müzik terapinin kanser hastalarının fiziksel ve ruhsal parametreleri üzerine etkisi
Geyik, Gizem İlayda (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Araştırma hematopoetik kök hücre nakli esnasında müzik terapinin kanser hastalarının fiziksel ve ruhsal parametreleri üzerine etkisini belirlemek amacıyla ön test ve son test ölçümlerin yapıldığı, deneysel desende dizayn ... -
Hepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on rats
Özbek, Hanefi; Kırmızı, Neriman İpek; Cengiz, Nureddin; Erdoğan, Ender (University of Istanbul, 2016)The aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution ... -
HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & Mey.) DC and its major compounds
Kırmızı Sönmez, Neriman İpek; Bahadır Acıkara, Özlem; Şakul, Ayşe Arzu; Bahtiyar, Bade Cevriye; Bardakçı, Hilal; Barak, Timur Hakan; Özbek, Hanefi (Elsevier B.V., 2022)Scorzonera L. (Asteraceae) species have long been the topic of many phytochemical, analytical, and biological studies since various species of the Scorzonera genus have been widely used as food and medicinal purposes. Apart ... -
Hypoglycemic activity of capparis ovata desf. Var. palaestina zoh. methanol extract
Okur, Mehmet Evren; Özbek, Hanefi; Çiçek Polat, Derya; Yılmaz, Sezen; Arslan, Rana (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2018)Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant are used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and ... -
In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
Kaya, Yasin Emre; Yılmaz, İbrahim; Karaarslan, Numan; Bilir, Bülent; Yaşar Şirin, Duygu; Özbek, Hanefi (Annals of Medical Research Publishing Inc, 2020)Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained ...