Yazar "Karaarslan, Numan" için listeleme
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Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Öznam, Kadir; Ateş, Özkan; Erdem, İlknur (Turkish Neurosurgical Society, 2018)AIM: To determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant ... -
Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats
Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi (Verduci Editore s.r.l, 2020)OBJECTIVE: The members of the matrix metalloproteinase (MMP) family and cannabinoids (CBs) are reportedly associated with hippocampus-dependent memory functions. However, the effects of endogenously formed CBs on hippocampal ... -
Practical performance of hippocampal tissue resection in rats in pharmacomolecular research
Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi (Turkish Neurosurgical Society, 2021)AIM: To explain how to resect hippocampal tissue in rats used as live mammalian subjects for the resection of fresh cerebral tissue in laboratories.MATERIAL and METHODS: Adult male Wistar-Albino rats (n=50) were used for ... -
Pregabalin treatment for neuropathic pain may damage intervertebral disc tissue
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaplan, Necati; Kaya, Yasin Emre; Akyuva, Yener; Gürbüz, Mehmet Sabri; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)The aim of the present study was to determine whether pharmaceutical preparations with pregabalin (PGB) as an active ingredient, which are widely prescribed by clinicians, exert toxic effects on human primary nucleus ... -
Spinal cerrahide gelecek vaat eden moleküler gelişmeler
Karaarslan, Numan; Yaşar Şirin, Duygu; Yılmaz, İbrahim; Özbek, Hanefi (Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2018)Amaç: Bu çalışmada, dünya genelinde yapılan çalışmalar içerisinde, omurga patolojisinin giderilmesinde araştırılan, moleküler düzeyde gerçekleştirilen hücresel bazlı hedef tedavilerin, sistematik olarak incelenip, konu ... -
A study of the effects of metformin, a biguanide derivative, on annulus fibrosus and nucleus pulposus cells
Kaya, Yasin Emre; Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akalan, Hande; Özbek, Hanefi (Turkish Neurosurgical Society, 2020)AIM: To investigate the effects of metformin, a drug used widely for the treatment of type 2 diabetes mellitus, on human primary cell cultures prepared from uninjured segment of disc material intervertebral disk tissues.MATERIAL ... -
A study on side effects of antibiotics used in the treatment of patients with head trauma and legal responsibility of clinicians in terms of the right to health
Karaarslan, Abdulkadir; Şimşek, Abdullah Talha; Doğan, Mustafa; Potoğlu, Bilgehan; Yılmaz, İbrahim; Karaarslan, Numan (2019)Aim: Patients with head trauma are routinely, and commonly treated with prophylactic antibiotics, which may also be used for the treatment of infection that may be developed during hospital stay. The relevant antibiotic ... -
A study on the effects of direct factor Xa inhibitors and direct thrombin inhibitors on human primary chondrocyte cultures
Kaya, Yasin Emre; Akalan, Hande; Yılmaz, İbrahim; Karaarslan, Numan; Yaşar Şirin, Duygu; Özbek, Hanefi; Ateş, Özkan (Namık Kemal University, 2019)Aim:This study investigates the effects of two direct factor Xa inhibitors, apixaban and rivaroxaban, and a direct thrombin inhibitor, dabigatran, on human primary chondrocytecultures. Materials and Methods:Monolayer ... -
Systematic evaluation of desmopressin administered to patients with aneurysmal subarachnoid hemorrhage in the light of the literature
Karaarslan, Numan; Yılmaz, İbrahim; Akgün, Feride Sinem; Çalışkan, Tezcan; Özbek, Hanefi; Ateş, Özkan (Turkish Neurosurgical Society, 2020)AIM: To discuss the management of patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) developing after subarachnoid hemorrhage, in a comparative manner in the light of the literature.MATERIAL ... -
Systematic evaluation of promising clinical trials-gene silencing for the treatment of glioblastoma
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Topuk, Savaş; Yaşar Şirin, Duygu; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field ... -
Toxicity of the acetyl-para-aminophenol group of medicines to intact intervertebral disc tissue cells
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu (Spandidos Publications Ltd., 2021)The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc ...