Hünerli Gündüz, DuyguÖzbek İşbitiren, YağmurUzunlar, HakanÇavuşoğlu, BerrinDönmez Çolakoğlu, BerrilAda, EmelGüntekin, BaharYener, Görsev2022-11-252022-11-252023Hünerli Gündüz, D., Özbek İşbitiren, Y., Uzunlar, H., Çavuşoğlu, B., Dönmez Çolakoğlu, B., Ada, E. ... Yener, G. (2023). Reduced power and phase-locking values were accompanied by thalamus, putamen, and hippocampus atrophy in Parkinson's disease with mild cognitive impairment: An event-related oscillation study. Neurobiology of Aging, 121, 88-106. https://doi.org/10.1016/j.neurobiolaging.2022.10.0010197-4580https://doi.org/10.1016/j.neurobiolaging.2022.10.001https://hdl.handle.net/20.500.12511/10028Parkinson's disease (PD) is a multifaceted neurodegenerative disorder accompanied by mild cognitive impairment (MCI) as a crucial nonmotor manifestation. Event-related oscillations (EROs) are suggested to reflect cognitive status associated with subcortical structures in neurodegenerative conditions. In this study, 36 individuals with PD-MCI and 32 PD-CN were compared with 60 healthy control (HC) participants using visual EROs by measures of event-related spectral perturbation and inter-trial coherence, along with subcortical gray matter volumes based on the FIRST algorithm. Cross-correlations among electrophysiological, neuropsychological, and structural parameters were investigated exploratively. Both PD-MCI and PD-CN patients had diminished delta and alpha phase-locking than HC, however, electrophysiological abnormalities were more pronounced in PD-MCI over frontal, central, parietal, and temporal locations in almost all frequency bands, accompanied by bilateral thalamus, hippocampus, and right putamen atrophy. PD-CN had lower hippocampal volumes than HC, without exhibiting any subcortical differences from PD-MCI. Lastly, EROs showed low-to-high correlations with structural and neuropsychological measures. These findings may highlight the complex interplay between electrophysiological, neuropsychological, and structural parameters in detected abnormalities of PD-CN and PD-MCI.eninfo:eu-repo/semantics/embargoedAccessBasal GangliaEvent-RelatedMild Cognitive ImpairmentOscillationParkinson's DiseasePhasePowerVolumetric MRIArticle1218810610.1016/j.neurobiolaging.2022.10.001Q20008932738000062-s2.0-8514200354536395544Q1