Keskin, İlknurGünal, Mehmet YalçınAytürk, NilüferKılıç, ÜlkanOzansoy, MehmetKılıç, Ertuğrul10.07.20192019-07-1010.07.20192019-07-102017Keskin, İ., Günal, M. Y., Aytürk, N., Kılıç, Ü., Ozansoy, M. ve Kılıç, E. (2017). Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury. Neural Regeneration Research, 12(5), 761-764. https://dx.doi.org/10.4103/1673-5374.2066461673-53741876-7958https://dx.doi.org/10.4103/1673-5374.206646https://hdl.handle.net/20.500.12511/3487WOS: 000403378800018PubMed ID: 28616032Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes. These findings suggest that enoxaparin exhibits neuroprotective effect on cold-induced traumatic brain injury in a dose-dependent manner.enAttribution-NonCommercial-ShareAlike 3.0 Unportedinfo:eu-repo/semantics/openAccessNerve RegenerationNeuroprotectionTraumatic Brain InjuryCold-Induced Brain InjuryEnoxaparinAnti-OxidativeApoptosisNeural RegenerationArticle12576176410.4103/1673-5374.206646Q2Q3