Polat, BurcuHelvacı Yılmaz, NesrinMantar, NagihanÇadırcı, FadimeSitrava, SevilayOzmansur, Elif NurdanUzan, MustafaÖzkara, ÇiğdemHano?lu, Lütfü2020-04-162020-04-162020Polat, B., Helvacı Yılmaz, N., Mantar, N., Çadırcı, F., Sitrava, S., Ozmansur, E. N. ... Hano?lu, L. (2020). Accelerated long-term forgetting after amygdalohippocampectomy in temporal lobe epilepsy. Journal of Clinical Neuroscience, 72, 43-49. https://dx.doi.org/10.1016/j.jocn.2020.01.0380967-58681532-2653https://hdl.handle.net/20.500.12511/5132https://dx.doi.org/10.1016/j.jocn.2020.01.038Aim of the study: Temporal lobe epilepsy (TLE) has been associated with the phenomenon of accelerated long-term forgetting (ALF). In this study, we aimed to demonstrate the effect of surgery on the ALF phenomena thus contributing to potential explanation of the causal mechanism.Materials and methods: We evaluated 51 patients with TLE related to hippocampal sclerosis who had amygdalohippocampectomy and had remained seizure-free after surgery. A control group consisted of 24 healthy individuals. All were given a verbal learning test assessing recall after 30 min, 1 week and 6 weeks.Results: In our study, the Left-TLE (L-TLE) group showed a statistically significant reduction in the performance at all assessment intervals from 30 min to 1 week compared to the Right-TLE and control groups regarding verbal learning memory test (VLMT) as well as for logical memory. The forgetting rates in the VLMT from 30 min to 1 week were not statistically significantly different between all 3 groups. The logical memory test results equally showed no statistically significant difference in the forgetting rates for the 3 groups between 30 min and 1 week.Conclusions and clinical implications: These results may support ongoing debates assuming the initial low performance in the memory of L-TLE patients to be directly related with left hippocampal-temporal tissue loss irrespective of epileptic activity. The discovery of the ALF phenomenon explains that standard memory tests are unable to detect memory loss in some patients who are experiencing a significant level of problems with forgetfulness in their daily lives.eninfo:eu-repo/semantics/embargoedAccessTemporal Lobe EpilepsyAmygdalohippocampectomyAccelerated Long-Term ForgettingArticle72434910.1016/j.jocn.2020.01.038Q4Q2