Serin, istemiCinli, Tahir AlperTunç, SertaçKaynar, LeylagülSevindik, Ömür GökmenYokuş, Osman2023-09-252023-09-252023Serin, İ., Cinli, T. A., Tunç, S., Kaynar, L., Sevindik, Ö. G. ve Yokuş, O. (2023). Inherited transmission of the CSF3R T618I mutation: A familial report. Annals of Hematology, 102(2), 477-479. https://doi.org/10.1007/s00277-022-05050-z0939-55551432-0584https://doi.org/10.1007/s00277-022-05050-zhttps://hdl.handle.net/20.500.12511/11495To the editor, Chronic neutrophilic leukemia (CNL) is a rare, break cluster region-Abelson 1 (BCR-ABL1) negative myeloproliferative neoplasm, which is characterized by mature neutrophilic proliferation with neutrophilic hyperplasia in bone marrow and hepatosplenomegaly [1]. The disease is frequently diagnosed at an advanced age; therefore, the median age of diagnosis was reported as 66.5 [2]. There are a few features that distinguish CNL from chronic myeloid leukemia (CML), such as more mature granulopoietic forms compared to CML, the preponderance of granulocytes (??80%) at the segmented or band stage of maturation, and minimal to no circulating blasts [1, 2]. Deterioration of thrombocytopenia along with increasing splenomegaly points out disease progression or blastic crisis [2].eninfo:eu-repo/semantics/embargoedAccessCSF3R T618IMutationInherited TransmissionLetter102247747910.1007/s00277-022-05050-zQ20008832102000022-s2.0-8514197573936376598Q1