Bülbül, Muhammet VolkanÖzbek, HanefiBahadır Acıkara, ÖzlemÖzbilgin, SerkanErgene Öz, BurçinKurtul, EkinKeskin, İlknur2022-03-022022-03-022018Bülbül, M. V., Özbek, H., Bahadır Acıkara, Ö., Özbilgin, S., Ergene Öz, B., Kurtul, E. ... Keskin, İ. (2018). Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells. Journal of Experimental and Clinical Medicine (Turkey), 35(4), 101-109. https://doi.org/10.5835/jecm.omu.35.04.0031309-4483https://doi.org/10.5835/jecm.omu.35.04.003https://hdl.handle.net/20.500.12511/9051In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apoptotic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.eninfo:eu-repo/semantics/openAccessApoptosisFlow CytometryHCT-116HEK-293NecrosisArticle35410110910.5835/jecm.omu.35.04.0032-s2.0-85105280785Q4