Atağ, EmineBaş İkizoğlu, NilayErgenekon, PınarKalın, SevinçÜnal, FüsunGökdemir, YaseminErdem Eralp, ElaYalçın, KorayÖktem, SedatErsu, RefikaKarakoç, FaziletKaradağ, Bülent2020-10-212020-10-212020Atağ, E., Baş İkizoğlu, N., Ergenekon, P., Kalın, S., Ünal, F., Gökdemir, Y. ... Karadağ, B. (2020). Health-related quality of life in patients with bronchiolitis obliterans. Pediatric Pulmonology, 55(9), 2361-2367. https://dx.doi.org/10.1002/ppul.248968755-68631099-0496https://dx.doi.org/10.1002/ppul.24896https://hdl.handle.net/20.500.12511/5956Introduction Bronchiolitis obliterans (BO) is mainly caused by infections and hematopoietic stem cell transplantation (HSCT). This study aimed to investigate the health-related quality of life (HRQOL) of children with BO compared to the healthy children and also to assess the HRQOL according to the etiology. Methods Postinfectious (group 1) and post-HSCT BO (group 2) patients and healthy children were included in the study. HRQOL was assessed by the Short Form-36 (SF-36) and St George's Respiratory Questionnaire (SGRQ). Correlations between demographic and clinical characteristics, pulmonary function tests, high-resolution chest tomography scores, and HRQOL were assessed. Results Thirty-seven postinfectious and post-HSCT BO patients and 34 healthy children were included in the study. Mean age was 13.8 +/- 0.7 years. Mean forced vital capacity and forced expiratory volume(1)were 60.7 +/- 2.7% predicted, and 49.8 +/- 3.1% predicted, respectively. The SF-36 scores were lower in BO patients compared to healthy children (P < .01). Patients with better lung functions had higher SF-36 scores, but lower SGRQ. The number of inhaled therapies, acute exacerbations, hospitalizations were inversely correlated with SF-36. A positive correlation was found between these parameters and total SGRQ scores (r = .507,P = .02;r = .409,P = .12;r = .326,P = .049, respectively). SF-36 scores were better in group 1 for subscales of physical role functioning and social role functioning compared to group 2. (P = .01,P = .01, respectively). Conclusion The HRQOL of patients with BO measured by SF-36 was low compared to healthy children. SF-36 scores were more affected in post-HSCT BO patients. HRQOL of children with chronic lung disease should be taken into consideration in the management of these patients.eninfo:eu-repo/semantics/embargoedAccessBronchiolitis ObliteransChildrenQuality of LifeArticle5592361236710.1002/ppul.24896Q2Q1