Surov, AlexeyGinat, Daniel ThomasLim, TchoyosonCabada, TeresaBaşkan, ÖzdilSchob, StefanMeyer, Hans JonasGihr, Georg AlexanderHorvath-Rizea, DianaHamerla, GordianHoffmann, Karl TitusWienke, Andreas10.07.20192019-07-1010.07.20192019-07-102018Surov, A., Ginat, D., Lim, T., Cabada, T., Başkan, Ö., Schob, S. ... Wienke, A. (2018). Histogram analysis parameters apparent diffusion coefficient for distinguishing high and low-grade meningiomas: A multicenter study. Translational Oncology, 11(5), 1074-1079. https://dx.doi.org/10.1016/j.tranon.2018.06.0101936-5233https://dx.doi.org/10.1016/j.tranon.2018.06.010https://hdl.handle.net/20.500.12511/1898WOS: 000444013200002PubMed ID: 30005209Low grade meningiomas have better prognosis than high grade meningiomas. The aim of this study was to measure apparent diffusion coefficient (ADC) histogram analysis parameters in different meningiomas in a large multicenter sample and to analyze the possibility of several parameters for predicting tumor grade and proliferation potential. Overall, 148 meningiomas from 7 institutions were evaluated in this retrospective study. Grade 1 lesions were diagnosed in 101 (68.2%) cases, grade 2 in 41 (27.7%) patients, and grade 3 in 6 (4.1%) patients. All tumors were investigated by MRI (1.5T scanner) by using diffusion weighted imaging (b values of 0 and 1000 s/mm (2)). For every lesion, the following parameters were calculated: mean ADC, maximum ADC, minimum ADC, median ADC, mode ADC, ADC percentiles P10, P25, P75, P90, kurtosis, skewness, and entropy. The comparison of ADC values was performed by Mann Whitney-U test. Correlation between different ADC parameters and KI 67 was calculated by Spearman's rank correlation coefficient. Grade 2/3 meningiomas showed statistically significant lower ADC histogram analysis parameters in comparison to grade 1 tumors, especially ADC median. A threshold value of 0.82 for ADC median to predict tumor grade was estimated (sensitivity = 82.2%, specificity = 63.8%, accuracy = 76.4%, positive and negative predictive values were 83% and 62.5%, respectively). All ADC parameters except maximum ADC showed weak significant correlations with KI 67, especially ADC P25 (P =-.340, P = .0001).enAttribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccessMeningiomaNeoplasmsAtypical MeningiomasArticle1151074107910.1016/j.tranon.2018.06.010Q2Q2