Stute, PetraSpyropoulou, AretiKarageorgiou, VasiliosCano, AntonioBitzer, JohannesCeausu, IulianaChedraui, PeterDurmuşoğlu, FatihErkkola, RistoGoulis, Dimitrios G.Hirschberg, Angelica LindenKiesel, LudwigLopes, PatricePines, AmosRees, MargaretVan Trotsenburg, MickZervas, IannisLambrinoudaki, Irene2020-01-032020-01-032020Stute, P., Spyropoulou, A., Karageorgiou, V., Cano, A., Bitzer, J., Ceausu, I. ... Lambrinoudaki, I. (2020). Management of depressive symptoms in peri- and postmenopausal women: EMAS position statement. Maturitas, 131, 91-101. https://doi.org/10.1016/j.maturitas.2019.11.0020378-51221873-4111https://doi.org/10.1016/j.maturitas.2019.11.002https://hdl.handle.net/20.500.12511/4884Introduction: Globally, the total number of people with depression exceeds 300 million, and the incidence rate is 70 % greater in women. The perimenopause is considered to be a time of increased risk for the development of depressive symptoms and major depressive episodes. Aim: The aim of this position statement is to provide a comprehensive model of care for the management of depressive symptoms in perimenopausal and early menopausal women, including diagnosis, treatment and follow-up. The model integrates the care provided by all those involved in the management of mild or moderate depression in midlife women. Materials and methods: Literature review and consensus of expert opinion. Summary recommendations: Awareness of depressive symptoms, early detection, standardized diagnostic procedures, personalized treatment and a suitable follow-up schedule need to be integrated into healthcare systems worldwide. Recommended treatment comprises antidepressants, psychosocial therapies and lifestyle changes. Alternative and complementary therapies, although widely used, may help with depression, but a stronger evidence base is needed. Although not approved for this indication, menopausal hormone therapy may improve depressive symptoms in peri- but not in postmenopausal women, especially in those with vasomotor symptoms.eninfo:eu-repo/semantics/openAccessDepressionPerimenopauseMenopausal TransitionEarly MenopauseMenopausal Hormone TherapyModel of CareEMASArticle1319110110.1016/j.maturitas.2019.11.002Q1Q1