Altun, Hamza YusufYang, FanMann, GiovanniEroğlu, Emrah2023-12-292023-12-292023Altun, H. Y., Yang, F., Mann, G. ve Eroğlu, E. (2023). Importance of physiological oxygen levels for endothelial redox signaling using Hyper 7. Free Radical Biology and Medicine içinde (S8-S9. ss.). Punta del Este, Uruguay, 15-18 November, 2023. https://dx.doi.org/10.1016/j.freeradbiomed.2023.10.0180891-58491873-4596https://dx.doi.org/10.1016/j.freeradbiomed.2023.10.018https://hdl.handle.net/20.500.12511/12077Cellular redox status is tightly linked to ambient oxygen levels. Endothelial cells (EC) in vivo are exposed to O2 levels between 3- 13 kPa, yet the majority in vitro studies maintain EC under atmospheric O2 levels (~18 O2). Under 18 kPa O2, EC are exposed to hyperoxia, leading to persistent upregulation of NRF2 regulated antioxidant defences. Exposure of EC to physiological O2 levels for at least 5 days attenuates NRF2-regulated antioxidant gene expression in the absence of HIF-1a stabilisation.eninfo:eu-repo/semantics/embargoedAccessHyper 7Endothelial Redox SignalingOxygen LevelsConference Object208Supplement: 1S8S910.1016/j.freeradbiomed.2023.10.018Q1001098825800009